Oropharyngeal Cleansing With 0.2% Chlorhexidine for Prevention of Nosocomial Pneumonia in Critically Ill Patients

Panchabhai, Tanmay S.; Dangayach, Neha; Krishnan, Anand; Kothari, Vatsal; Karnad, Dilip R.

doi:10.1378/chest.08-1321

Cited by 111 publications

(100 citation statements)

References 26 publications

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“…Moreover, published results regarding the efficacy of a local antiseptic and oral hygiene in preventing VAP are controversial. 40,41 The prospective, randomized, and controlled trial conducted by Segers et al 42 to determine the efficacy of chlorhexidine gluconate in decreasing nosocomial infection after cardiac surgery showed a lower incidence of deep surgical site infections and lower respiratory tract infections, including tracheobronchitis and VAP, in chlorhexidine gluconate-treated patients. In contrast with other reports, analysis of postoperative infections showed similar percentages of surgical site infections in both groups.…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Hygiene and 0.12% Chlorhexidine Gluconate Oral Rinse in Preventing Ventilator-Associated Pneumonia After Cardiovascular Surgery

et al. 2013

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BACKGROUND: Ventilator-associated pneumonia (VAP) is a nosocomial infection of multifactorial etiology and has a negative influence on cardiovascular surgery (CVS) outcomes. OBJECTIVES: Determine the effect of toothbrushing plus 0.12% chlorhexidine gluconate oral rinse in preventing VAP after CVS. METHODS: In a quasi-experimental study, patients undergoing heart surgery were enrolled in a protocol for controlling dental biofilm by proper oral hygiene (toothbrushing) and oral rinses with 0.12% chlorhexidine gluconate (Group 1), and they were compared with a historical control group (Group 2), which included patients who underwent cardiac surgery be-

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Section: Discussionmentioning

confidence: 99%

Effect of Oral Hygiene and 0.12% Chlorhexidine Gluconate Oral Rinse in Preventing Ventilator-Associated Pneumonia After Cardiovascular Surgery

et al. 2013

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“…Chlorhexidine at varying concentrations, however, has been evaluated in more than 11 trials. Impacts on VAP rates have been variable: three reported decreases [64][65][66] while the other eight did not [67][68][69][70][71][72][73][74]. One trial reported a decrease in antibiotic usage for patients treated with chlorhexidine [67].…”

Section: Oral Antiseptics and Antibioticsmentioning

confidence: 99%

Prevention of ventilator-associated pneumonia

Klompas¹

2010

Expert Review of Anti-infective Therapy

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“…Like the use of ODD, oral chlorhexidine administration has been associated with reductions in nosocomial infections, including VAP, primarily in patients undergoing cardiac surgery [19,20]. The overall magnitude of the effect on the prevention of VAP seems to be modest and probably is dependent on both the frequency of its administration and the concentration of chlorhexidine, as demonstrated in non-cardiac surgery populations [21,22].…”

Section: Prevention Of Nosocomial Pneumoniamentioning

confidence: 99%

Prevention of Nosocomial Pneumonia in the Intensive Care Unit: Beyond the Use of Bundles

Kollef

2011

Surgical Infections

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Background: The occurrence of nosocomial pneumonia (NP) in the hospital setting is especially problematic, as it is associated with a greater risk of in-hospital death, longer stays on mechanical ventilation and in the intensive care unit (ICU), more need for tracheostomy, and significantly higher medical care costs. Methods: Review of the pertinent English-language literature. Results: The adverse effect of NP on healthcare outcomes has increased pressure on clinicians and hospital systems to prevent this infection. This brief review provides an overview of the current approaches to the prevention of NP, focusing primarily on ventilator-associated pneumonia (VAP). Conclusion: Clinicians working in ICUs should consider the following recommendations: (1) Develop a VAP prevention bundle based on evidence-based guidelines; (2) monitor the rates of VAP prior to and during implementation of the program; (3) make adjustments according to VAP occurrence; and (4) integrate VAP prevention with other quality improvement programs.

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Oropharyngeal Cleansing With 0.2% Chlorhexidine for Prevention of Nosocomial Pneumonia in Critically Ill Patients

Cited by 111 publications

References 26 publications

Effect of Oral Hygiene and 0.12% Chlorhexidine Gluconate Oral Rinse in Preventing Ventilator-Associated Pneumonia After Cardiovascular Surgery

Effect of Oral Hygiene and 0.12% Chlorhexidine Gluconate Oral Rinse in Preventing Ventilator-Associated Pneumonia After Cardiovascular Surgery

Prevention of ventilator-associated pneumonia

Prevention of Nosocomial Pneumonia in the Intensive Care Unit: Beyond the Use of Bundles

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