Oropharyngeal carcinoma treated with radiotherapy: A 30-year experience

Fein, Douglas A.; Lee, William R.; Amos, Warren R.; Hinerman, Russell W.; Parsons, James T.; Mendenhall, William M.; Stringer, Scott P.; Cassisi, Nicholas J.; Million, Rodney R.

doi:10.1016/0360-3016(95)02028-4

Cited by 130 publications

(76 citation statements)

References 67 publications

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“…We found a high incidence of nodal metastases (61%), which has also been observed in other studies (20,21). This contrasts with the more moderate incidence of onethird in carcinomas of the oral cavity and 3% of the glottic larynx.…”

Section: Discussionsupporting

confidence: 86%

“…Others also reported this nding, even in advanced cases (22). In our material distant metastases were relatively rare phenomena (7%) and were frequently discovered along with a locoregional recurrence, while other workers report a higher incidence (21). The dominating problem remains the isolated recurrences in the T position, in our material amounting to 55% of the recurrences (33% of all the patients).…”

Section: Discussionsupporting

confidence: 60%

“…The dominating problem remains the isolated recurrences in the T position, in our material amounting to 55% of the recurrences (33% of all the patients). In a material of 490 patients with oropharyngeal carcinomas it was reported that radiotherapy treatment results in tumour control and survival rates comparable with those achieved with combined irradiation and surgery, with less morbidity (21). A study including 105 patients reported equal success using radiotherapy or surgery (23).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Squamous Cell Carcinoma of the Oropharynx-An Analysis of Treatment Results in 289 Consecutive Patients

Johansen

Grau²,

Overgaard

2000

Acta Oncologica

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Squamous Cell Carcinoma of the Oropharynx-An Analysis of Treatment Results in 289 Consecutive Patients

Johansen

Grau²,

Overgaard

2000

Acta Oncologica

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“…[1][2][3][4][5][6][7][8] There are no dedicated randomized trials that have focused on comparing radiotherapy versus surgery for oropharyngeal carcinoma. Radiotherapy is preferred at many centers because of presumed lower morbidity and better functional and cosmetic outcome compared with surgical treatment, particularly with the increased use of chemoradiation.…”

mentioning

confidence: 99%

Intensity‐modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma

Huang

Xia

Chuang

et al. 2008

Cancer

124

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BACKGROUND.Treatment outcomes for stage III and IV oropharyngeal carcinoma treated with intensity‐modulated radiotherapy (IMRT) and concurrent chemotherapy without prior surgical resection were reviewed.METHODS.Between April 2000 and September 2004, 71 patients underwent IMRT concurrent with chemotherapy without prior surgical resection for stage III and IV oropharyngeal carcinoma. Chemotherapy was platinum based. The gross tumor volume (GTV) received 70 Gy in 2.12 Gy per fraction. The high‐risk clinical tumor volume (CTV) received 59.4 Gy in 1.80 Gy per fraction, and the low‐risk CTV received 54 Gy in 1.64 Gy per fraction.RESULTS.With a median follow‐up of 33 months, the 3‐year local, regional, and locoregional progression‐free probabilities were 94%, 94%, and 90%, respectively. The 3‐year overall survival estimate was 83%. Locoregional failures occurred in the GTV in 7 patients. Acute grade 3 or 4 toxicity developed in 35 patients. A feeding gastrostomy was placed in 25 patients. Late xerostomia was grade 0 in 16 patients, grade 1 in 31 patients, and grade 2 in 24 patients at last follow‐up. No patients experienced grade 3 or 4 late toxicity, except for 1 who developed osteoradionecrosis of the mandible.CONCLUSIONS.Excellent local and regional control was achieved with IMRT and concurrent chemotherapy without prior surgical resection in the treatment of stage III and IV oropharyngeal carcinoma. Significant sparing of the parotid glands and other critical normal tissues was possible using IMRT with moderate acute toxicities and minimal severe late effects. Cancer 2008. © 2008 American Cancer Society.

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“…Following radiotherapy, the clinical situation is usually com plicated with post-therapy residual masses which encumber the evaluation of response to therapy in patients with NPC (1,3,18). When there is persistent viable tumor, booster dose irradiation, intracavitary brachytherapy and/or radical neck dissection or innovative combined therapy approaches could be added to the therapeutic protocol (2,(19)(20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Carcinoma

Lin

Lee

2011

Decision Making in Radiation Oncology

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This study prospectively assessed the value of 201TI and 99nTc-sestamibi (MIBI) SPECT in monitoring disease regression/progres sion as compared with MRI findings in patients with nasopharyngeal carcinoma (NPC) having radiotherapy with or without chemother apy. Methods: Eighteen patients (age range 15-76 yr, mean 45 yr) had consecutive SPECT imaging using a dual-head gamma camera after the injection of 111 MBq 201TI and 555 MBq MIBI before therapy and at 3 mo and 6 mo after completion of therapy. A total of 106 SPECT studies was correlated with contemporaneous MRI studies. Tumor-to-background ratios were obtained on coronal slices. Visually detectable lesions in the region of the nasopharynx and cervical lymph nodes were considered positive for residual disease. The gold standard for the presence of disease was the combination of repeat MRI scans, endoscopie examination and clinical evaluation performed 12-15 mo after completion of therapy. Results: MIBI-SPECT proved superior to both 201TI SPECT and MRI after 3 or 6 mo follow-up in predicting complete response. Accuracy rates in the detection of residual disease in the nasophar ynx are 39%, 72% and 89% for MRI, 201TIand MIBI, respectively, for the 3-mo evaluation; 71%, 71% and 94% for MRI, 201TI and MIBI, respectively, for the 6-mo evaluation. Conclusion: MIBI SPECT could be used as a screening test in predicting response to therapy in patients with NPC.

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Oropharyngeal carcinoma treated with radiotherapy: A 30-year experience

Cited by 130 publications

References 67 publications

Squamous Cell Carcinoma of the Oropharynx-An Analysis of Treatment Results in 289 Consecutive Patients

Squamous Cell Carcinoma of the Oropharynx-An Analysis of Treatment Results in 289 Consecutive Patients

Intensity‐modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma

Nasopharyngeal Carcinoma

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