Oropharyngeal cancer: a potential consequence of concomitant HPV and HIV infection

Gillison, Maura L.

doi:10.1097/cco.0b013e32832f3e1b

Cited by 79 publications

(84 citation statements)

References 62 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the US, HIV infection is associated with a two-to threefold increased risk of HNSCC, 90 although whether this results from increasing mucosal HPV rates and greater susceptibility to HPV oncogenesis, increased tobacco and alcohol use, or both, is uncertain. 91 Limited data suggest that HIV-infected HNSCC patients in sub-Saharan Africa may be younger, with infrequent tobacco and alcohol use, more aggressive cancers, and worse clinical outcomes. 38,39 The effect of antiretroviral therapy (ART) scale-up on cancer incidence overall, and HNSCC incidence specifically, remains uncertain.…”

Section: 89mentioning

confidence: 99%

Review: Head and neck squamous cell carcinoma in sub-Saharan Africa

Faggons¹,

Mabedi²,

Shores³

et al. 2015

Mal. Med. J

View full text Add to dashboard Cite

AimReview the literature from 1990 to 2013 to determine known anatomic sites, risk factors, treatments, and outcomes of head and neck squamous cell carcinoma (HNSCC) in sub-Saharan Africa. MethodsUsing a systematic search strategy, literature pertaining to HNSCC in sub-Saharan Africa was reviewed and patient demographics, anatomic sites, histology, stage, treatment, and outcomes were abstracted. The contributions of human immunodeficiency virus (HIV), human papillomavirus (HPV) and behavioural risk factors to HNSCC in the region were assessed. ResultsOf the 342 papers identified, 46 were utilized for review, including 8611 patients. In sub-Saharan Africa, the oropharyngeal/oral cavity was found to be the most common site, with 7750 cases (90% of all cases). Few papers distinguished oropharyngeal from oral cavity, making identification of possible HPV-associated oropharyngeal squamous cell carcinoma (SCC) difficult. SCC of the nasopharynx, nasal cavity, or paranasal sinuses was identified in 410 patients (4.8% of all cases). Laryngeal SCC was found in 385 patients (4.5% of all cases), and only 66 patients (0.8% of all cases) with hypopharyngeal SCC were identified. In 862 patients with data available, 43% used tobacco and 42% used alcohol, and reported use varied widely and was more common in laryngeal SCC than that of the oropharyngeal/oral cavity. Toombak and kola nut use was reported to be higher in patients with HNSCC. Several papers reported HIV-positive patients with HNSCC, but it was not possible to determine HNSCC prevalence in HIV-positive compared to negative patients. Reports of treatment and outcomes were rare. ConclusionsThe oropharyngeal/oral cavity was by far the most commonly reported site of HNSCC reported in sub-Saharan Africa. The roles of risk factors in HNSCC incidence in sub-Saharan Africa were difficult to delineate from the available studies, but a majority of patients did not use tobacco and alcohol.

show abstract

Section: 89mentioning

confidence: 99%

Review: Head and neck squamous cell carcinoma in sub-Saharan Africa

Faggons¹,

Mabedi²,

Shores³

et al. 2015

Mal. Med. J

View full text Add to dashboard Cite

show abstract

“…HPV-positive oropharyngeal cancer is often of nonkeratinizing histology (basaloid, lymphoepithelial, or poorly differentiated carcinoma), and patients typically present with latestage disease characterized by small primary tumors and advanced nodal metastases (Gillison 2009;Sturgis and Ang 2011). These patients also have distinct demographic characteristics: compared with patients with HPV-negative oropharyngeal cancer, patients with HPV-positive oropharyngeal cancer typically present at younger ages and are more likely to be white men of high socioeconomic status (Gillison 2009;Sturgis and Ang 2011).…”

Section: Introductionmentioning

confidence: 97%

“…Developed countries with established ▶ cervical cancer screening programs in place have higher proportions of noncervical than cervical HPV-associated cancers, while ▶ developing countries without such programs have a high burden of ▶ cervical cancer that far outweighs the burden of other HPV-associated cancers (Chaturvedi 2010). may arise from either of two distinct etiologic pathways, one associated with HPV and one associated with tobacco exposure (Gillison 2009;Sturgis and Ang 2011). The incidence of oropharyngeal cancer is increasing in the United States despite a decrease in smoking prevalence (Sturgis and Ang 2011).…”

Section: Introductionmentioning

confidence: 98%

“…Between 25 % and 40 % of HIV-positive individuals have a prevalent oral HPV infection, compared with only 5-10 % of individuals in the general population (Gillison 2009;Gillison et al 2012). However, it remains unclear what proportion of oropharyngeal cancers among HIV-positive individuals should be attributed to HPV and what proportion should be attributed to smoking and alcohol use.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Other HPV-Associated Cancers (Oropharyngeal and Penile)

Dahlstrom¹

2013

Encyclopedia of AIDS

View full text Add to dashboard Cite

Definition▶ Human papillomavirus (HPV) has been recognized as an etiologic agent in malignancies at several anatomic sites, including the oropharynx and the penis. The overwhelming majority of oropharyngeal and penile cancers are squamous cell carcinomas. It is estimated that approximately two-thirds of oropharyngeal cancers and half of penile cancers can be attributed to HPV infection. The incidence of HPV-associated oropharyngeal cancers is rapidly increasing in developed countries. Penile cancer remains rare in developed countries but constitutes a major cancer burden among men in developing countries. Compared with the general population, patients with HIV/AIDS are at increased risk for HPV-associated cancers, including oropharyngeal and penile cancers.

show abstract

“…Анало-гично этому пациенты, инфицированные вирусом иммунодефицита человека, имеют в 2-6 раз более высокий риск развития рака ротоглотки в сравнении со здоровой популяцией [11].…”

unclassified

Nivolumab in the Treatment of Refractory Recurrent and Metаstatic Head and Neck Squamous Cell Carcinoma. The Results of a Phase Iii Clinical Trial (Checkmate 141)

Мудунов¹

2017

Opuholi golovy šei

View full text Add to dashboard Cite

Oropharyngeal cancer: a potential consequence of concomitant HPV and HIV infection

Cited by 79 publications

References 62 publications

Review: Head and neck squamous cell carcinoma in sub-Saharan Africa

Review: Head and neck squamous cell carcinoma in sub-Saharan Africa

Other HPV-Associated Cancers (Oropharyngeal and Penile)

Nivolumab in the Treatment of Refractory Recurrent and Metаstatic Head and Neck Squamous Cell Carcinoma. The Results of a Phase Iii Clinical Trial (Checkmate 141)

Contact Info

Product

Resources

About