Oropharyngeal Cancer

Kodaira, Takeshi; Shimizu, Arisa; Takehana, Keiichi

doi:10.1007/978-4-431-55486-8_9

Cited by 1 publication

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References 31 publications

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“…This association between HPV and oropharyngeal cancer has brought new insights into the understanding of the mechanisms of development of this type of cancer and has led to important changes in the management and treatment of patients. For example, an increased prevalence of HPV 16 infections is observed in oropharyngeal cancer, which may influence screening, diagnostic, and therapeutic strategies [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Analysis from Western Romania Comparing the Treatment and Survivability of p16-Positive versus p16-Negative Oropharyngeal Cancer

Chioreanu,

Balica,

Mot

et al. 2024

Cancers

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Background: Oropharyngeal cancer is a global health concern due to its multifaceted nature. Recent molecular studies have linked p16 overexpression, associated with the human papillomavirus, to oropharyngeal cancer and its prognostic implications. Materials and Methods: This retrospective study in Western Romania examined 60 patients, categorizing them based on p16 biomarker status: 28 were p16 positive, and 32 were p16 negative. Statistical tests, including Fisher’s exact and chi2, were used for analysis. Results: Patients with p16-positive oropharyngeal cancer exhibited a better prognosis (3-year survival, p = 0.0477; midtreatment, p = 0.0349) and reported lower alcohol (p = 0.0046) and tobacco (p < 0.0001) use. Conclusions: The study highlights the importance of p16 testing in oropharyngeal carcinoma diagnosis. It suggests modifying treatment approaches based on p16 status and underscores the differing prognoses associated with p16-positive and p16-negative cases.

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Section: Introductionmentioning

confidence: 99%