Orogranulocyte Peroxidase Activity as a Measure of Inflammatory Periodontal Disease

Klinkhamer, James M.; Mitchell, Marcella D.

doi:10.1177/00220345790580011501

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…Myeloperoxidase activity is increased in gingival fluid during inflammation (4), and this increase may be reflected also in whole saliva (38). In our present study the correlation of myeloperoxidase to GBI was +0.23, which is about the same as for lactoferrin.…”

Section: Discussionsupporting

confidence: 69%

Antimicrobial systems of human whole saliva in relation to dental caries, cariogenic bacteria, and gingival inflammation in young adults

Gråhn

Tenovuo

Lehtonen

et al. 1988

Acta Odontologica Scandinavica

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The association of salivary antibody (total IgA, IgG, and IgM and antibodies reactive with Streptococcus mutans) and non-antibody (lysozyme, lactoferrin, salivary peroxidase, myeloperoxidase, hypothiocyanite, thiocyanate) defense factors with oral health (past and present dental caries, gingival bleeding, the number of salivary S. mutans and lactobacilli) were studied in 50 naval recruits. Dental caries was significantly associated with large amounts of S. mutans, lactobacilli, and total salivary immunoglobulins and with low salivary flow rate and buffer capacity. Salivary anti-S. mutans antibodies did not correlate with dental caries or S. mutans levels. Moreover, none of the salivary non-antibody factors alone had any strong relationship to dental caries or S. mutans levels. Gingival inflammation was associated with elevated levels of lysozyme in whole saliva. It is concluded that in adults the associations between single-point measurements of most salivary antimicrobial constituents and the factors describing oral health are weak.

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Section: Discussionsupporting

confidence: 69%

Antimicrobial systems of human whole saliva in relation to dental caries, cariogenic bacteria, and gingival inflammation in young adults

Gråhn

Tenovuo

Lehtonen

et al. 1988

Acta Odontologica Scandinavica

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“…Human gingival crevice is the major source of oral leukocytes and the gingival exudate contains MP (13), halides, and SCN- (1). Orogranulocyte peroxidase activity (MP) and the severity of periodontal disease seem to correlate positively (12). It is also known that human dental plaque is able to release MP from polymorphonuclear leukocytes (30).…”

Section: Resultsmentioning

confidence: 99%

“…Growing interest has recently been focused on innate, nonimmunoglobulin defense factors in the human mouth (14; I. D. Mandel and S. A. Ellison, in K. M. Pruitt and J. Tenovuo, ed., Chemistry and Biological Significance of the Lactoperoxidase System, in press) and on their possible association with dental caries (7,17) or periodontal diseases (12,13). However, because many innate (lysozyme, peroxidase, lactoferrin, agglutinins, etc.)…”

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confidence: 99%

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Antibacterial effect of lactoperoxidase and myeloperoxidase against Bacillus cereus

Tenovuo¹,

Mäkinen²,

Sievers³

1985

Antimicrob Agents Chemother

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An oral periodontopathic bacterium, Bacillus cereus, was inhibited both by lactoperoxidase (LP) and myeloperoxidase (MP) antimicrobial systems. With the LP-SCN--H202 system, the growth inhibition was directly proportional to the amount of OSCN-ions present. The OSCN-, which is the principal oxidation product of the LP (or MP)-SCN--H202 system at neutral pH, is a normal component of human saliva. The oxidation products of both peroxidase systems inhibited the growth of the bacteria. This inhibition was associated with reduced extracellular release of collagenase activity from the cells. With LP, the antimicrobial efficiency of the oxidizable substrates was SCN-> I-, and with MP, the efficiency was I-> Cl > SCN-, respectively. LP did not oxidize Cl1.

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“…Human whole saliva has peroxidase activity derived from both the .salivary glands and oral polymorphonuclear leukocytes (13,26,27). Polymorphonuclear leukocytes rapidly lyse when they enter saliva (28) and release high amounts of myeloperoxidase (27). Accordingly, increased salivary myeloperoxidase activity is associated with oral inflammation (13).…”

Section: Discussionmentioning

confidence: 99%

Changes in composition of whole saliva in patients with fissured tongue

Kullaa-Mikkonen

Tenovuo

Sorvari

1985

European J Oral Sciences

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– Both resting and paraffin‐stimulated whole saliva were studied in 25 patients with fissured tongue and in their age and sex‐matched healthy controls. The groups did not differ in dental or periodontal health. No significant differences were found between the groups in the salivary secretion rate, pH and buffer capacity, or in the frequency of lactobacilli and yeasts in saliva samples and scrapings from tongue surface. In patients with fissured tongue, unstimulated whole saliva displayed significantly elevated levels of sodium, lysozyme, myeloperoxidase and all immunoglobulins (isotypes A, G and M) when compared with the controls. These changes most likely reflect the inflammation frequently seen in the biopsies of fissured tongue. No differences between the groups existed in the amounts of salivary potassium, calcium, inorganic phosphate, amylase and total protein. Our study shows that in patients with fissured tongue the salivary secretion and composition are normal. However, components from plasma and inflammatory cells are diagnostically elevated in the whole saliva samples of patients with fissured tongue when compared with the healthy controls.

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Orogranulocyte Peroxidase Activity as a Measure of Inflammatory Periodontal Disease

Cited by 10 publications

References 6 publications

Antimicrobial systems of human whole saliva in relation to dental caries, cariogenic bacteria, and gingival inflammation in young adults

Antimicrobial systems of human whole saliva in relation to dental caries, cariogenic bacteria, and gingival inflammation in young adults

Antibacterial effect of lactoperoxidase and myeloperoxidase against Bacillus cereus

Changes in composition of whole saliva in patients with fissured tongue

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