Orofacial somatomotor responses in the macaque monkey homologue of Broca's area

Petrides, Michael; Cadoret, Geneviève; Mackey, Scott

doi:10.1038/nature03628

Cited by 301 publications

(262 citation statements)

References 25 publications

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“…In electrophysiological work in non-human primates, a subset of mirror neurons in area F5 were active both when the monkey grasped an object with the hand, and with the mouth . In another study, mirror neurons in the same area (F5), which has been proposed as a monkey homolog of Broca's area in humans (Petrides et al 2005), discharged both when a monkey performed an action and when it was presented with an acoustic stimulus associated with that action (Kohler et al 2002). A similar pattern in humans has been observed in a tempero-parieto-premotor circuit using fMRI (Gazzola et al 2006).…”

mentioning

confidence: 54%

Observed effector-independent motor learning by observing

Williams

Gribble

2012

Journal of Neurophysiology

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Williams A, Gribble PL. Observed effector-independent motor learning by observing. J Neurophysiol 107: 1564 -1570, 2012. First published December 21, 2011 doi:10.1152/jn.00748.2011pelling idea in cognitive neuroscience links motor control and action observation. Recent work supports the idea that a link exists not just between action observation and action planning, but between observation and motor learning. Several studies support the idea that cortical regions that underlie active motor learning also play a role in motor learning by observing. The goal of the present study was to test whether motor learning by observing is effector dependent (as in active motor learning) or effector independent (as in studies of action observation and mirror neurons). Right-handed human subjects observed a video depicting another individual learning to reach to visual targets in a force field (FF). The video showed reaching in a clockwise FF (CWFF) or a counter-clockwise FF (CCWFF), and depicted an individual reaching with the right or left arm. After observation, all subjects were asked to reach in a CWFF, using their right arm. As in our prior studies, subjects who observed a CWFF prior to the CWFF test performed better than subjects who observed a CCWFF. We show here that this effect was seen both when observers watched others reach using their right arm, and when observers watched others learning to reach using the left arm. These results suggest that information about novel forces learned through observation is represented in an effector-independent coordinate frame, and are consistent with the idea that the brain links not only observation and movement, but motor learning as well, through abstract representations of actions.

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confidence: 54%

Observed effector-independent motor learning by observing

Williams

Gribble

2012

Journal of Neurophysiology

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“…Several recent studies revealed that BA 44/45 in non-human primates can be seen as a monkey's homologue of Broca's area 25 , which is crucial for speech control in humans 33 . BA 44/45 shows anatomical similarities, comparable cytoarchitectonics 24 as well as similar cortico-cortical projections as Broca's area 24 .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, functional commonalities have emerged over the past years. Electrical microstimulation in BA 44 elicited orofacial responses 25 , and auditory stimulation evoked distinct patterns of brain activity in BA 44 and 45 only with species-specific vocalizations in awake behaving rhesus monkeys 28,29 that were comparable to responses in the human Broca's area 30 . The vlPFC might thus be ideally positioned to gain cognitive control over call initiation.…”

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confidence: 97%

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Single neurons in monkey prefrontal cortex encode volitional initiation of vocalizations

2013

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Broca's area in the ventrolateral prefrontal cortex (vlPFC) has a crucial role in human volitional speech production; damage to this area causes severe impairment of speech production. Lesions in PFC of monkeys, however, have only mild effects on spontaneous vocal behaviour. Non-human primate vocalizations are thus believed to constitute affective utterances processed by a subcortical network. Here in contrast to this assumption, we show that rhesus monkeys can control their vocalizations in a goal-directed way. During single-cell recordings in the vlPFC of monkeys trained to vocalize in response to visual cues, we find call-related neurons that specifically predict the preparation of instructed vocalizations. The activity of many call-related neurons before vocal output correlates with call parameters of instructed vocalizations. These findings suggest a cardinal role of the monkey homologue of Broca's area in vocal planning and call initiation, a putative phylogenetic precursor in non-human primates for speech control in linguistic humans.

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“…BA 44 is clearly identifiable in the human brain and is thought to be a central brain region for human speech processing (Friederici, 2012). Petrides et al (2005) recently described a cytoarchitectonically similar area in macaque monkeys. The subregions in the IFC seem to have equal representation in both the left and the right IFC.…”

Section: Anatomy and Functions Of The Lateral Ifcmentioning

confidence: 99%

Processing of emotional vocalizations in bilateral inferior frontal cortex

Frühholz

Grandjean

2013

Neuroscience & Biobehavioral Reviews

103

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a b s t r a c tA current view proposes that the right inferior frontal cortex (IFC) is particularly responsible for attentive decoding and cognitive evaluation of emotional cues in human vocalizations. Although some studies seem to support this view, an exhaustive review of all recent imaging studies points to an important functional role of both the right and the left IFC in processing vocal emotions. Second, besides a supposed predominant role of the IFC for an attentive processing and evaluation of emotional voices in IFC, these recent studies also point to a possible role of the IFC in preattentive and implicit processing of vocal emotions. The studies specifically provide evidence that both the right and the left IFC show a similar anterior-to-posterior gradient of functional activity in response to emotional vocalizations. This bilateral IFC gradient depends both on the nature or medium of emotional vocalizations (emotional prosody versus nonverbal expressions) and on the level of attentive processing (explicit versus implicit processing), closely resembling the distribution of terminal regions of distinct auditory pathways, which provide either global or dynamic acoustic information. Here we suggest a functional distribution in which several IFC subregions process different acoustic information conveyed by emotional vocalizations. Although the rostro-ventral IFC might categorize emotional vocalizations, the caudo-dorsal IFC might be specifically sensitive to their temporal features.

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Orofacial somatomotor responses in the macaque monkey homologue of Broca's area

Cited by 301 publications

References 25 publications

Observed effector-independent motor learning by observing

Observed effector-independent motor learning by observing

Single neurons in monkey prefrontal cortex encode volitional initiation of vocalizations

Processing of emotional vocalizations in bilateral inferior frontal cortex

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