Orofacial Manifestations Associated with Muscular Dystrophies: A Review

Papaefthymiou, Petros; Kekou, Kyriaki; Özdemir, Fulya

doi:10.5152/turkjorthod.2021.21021

Cited by 9 publications

(11 citation statements)

References 51 publications

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“…The most common dental occlusion changes reported were anterior open bite and posterior crossbite 3 . An increased prevalence of Class II malocclusion in patients with DM1 was also reported in the literature 12,13 …”

Section: Introductionmentioning

confidence: 59%

“…This condition could lead the overeruption of the posterior dentition and posterior crossbite, as it has been reported before 3 . Also Papaefthymiou et al showed that the posterior crossbite's etiologic factor in DM1 patients was the narrower maxillary arch which affected by muscular weakness 12 . Kiliaridis et al 3 and Mercier et al 16 suggested that dental malocclusions and skeletal alterations observed in DM1 patients, are associated with the degree of masticatory muscle involvement.…”

Section: Discussionmentioning

confidence: 85%

“…13 Papaefthymiou et al specified that the increased prevalence of Class II malocclusion in patients with DM1 is quite possibly linked to the mandibular posterior rotation. 12 In the study of Fontinha et al, it was represented that DM1 patients exhibited a retrognathic profile and a high prevalence of malocclusions. 17 The other findings of the present study were high prevalence of flat-shaped mandibular condyle (48.5%), high frequency of flattening (37.9%) among patients with DM1, and a statistically significant difference between DM1 and healthy controls according to the prevalence of osseous changes observed in the condyle.…”

Section: Ta B L Ementioning

confidence: 98%

“…3 Also Papaefthymiou et al showed that the posterior crossbite's etiologic factor in DM1 patients was the narrower maxillary arch which affected by muscular weakness. 12 Kiliaridis et al 3 and Mercier et al 16 suggested that dental malocclu- etal Class II. 13 Papaefthymiou et al specified that the increased prevalence of Class II malocclusion in patients with DM1 is quite possibly linked to the mandibular posterior rotation.…”

Section: Ta B L Ementioning

confidence: 99%

“…3 An increased prevalence of Class II malocclusion in patients with DM1 was also reported in the literature. 12,13 Various radiological imaging modalities can be used for evaluating the osseous components of TMJ. Cone-beam computed tomography (CBCT) provide better visualisation of bone structures and analysis of pathological changes with a lower cost and radiation dose.…”

Section: Introductionmentioning

confidence: 99%

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The effect of myotonic dystrophy type 1 on temporomandibular joint and dentofacial morphology: A CBCT analysis

Evlıce

Yüksel

Evlice

et al. 2023

J of Oral Rehabilitation

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BackgroundMyotonic dystrophy type 1 (DM1) is a neuromuscular multisystem disease. Early involvement of facial muscles may produce an extra load on the temporomandibular joint (TMJ) in DM1.ObjectivesThis study aimed to investigate the morphological analyses of the bone components of temporomandibular joint (TMJ), and dentofacial morphology in myotonic dystrophy type 1 (DM1) patients by cone‐beam computed tomography (CBCT).MethodsSixty‐six individuals (33 DM1, and 33 healthy subjects) age ranging from 20 to 69 were included in the study. Clinical examinations of the patients' TMJ regions and evaluation of dentofacial morphology (maxillary deficiency, open‐bite, deep palate and cross‐bite) were performed. Dental occlusion was determined based on Angle's classification. CBCT images were evaluated regarding mandibular condyle morphology (convex, angled, flat and round) and osseous changes observed in the condyle (normal, osteophyte, erosion, flattening, sclerosis). DM1‐specific morphological and bony TMJ alterations were determined.ResultsDM1 patients showed a high prevalence of morphological and osseous TMJ changes, and statistically significant skeletal alterations. The analysis of CBCT scans indicated the prevalent condylar shape among patients with DM1 was flat, the main osseous abnormality was flattening, there was a tendency towards skeletal Class II and a posterior cross‐bite was frequently detected in DM1 patients. There was no statistically significant difference between the genders on the parameters evaluated in both groups.ConclusionAdult patients with DM1 presented a high frequency of crossbite, tendency to skeletal Class II and morphological osseous alterations of TMJ. The analysis of the morphological condylar alterations in patients with DM1 may be beneficial in the diagnosis of TMJ disorders. This study reveals DM1‐specific morphological and osseous TMJ alterations to provide an appropriate orthodontic/orthognathic treatment planning to patients.

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Section: Introductionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 85%

Section: Ta B L Ementioning

confidence: 98%

Section: Ta B L Ementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of myotonic dystrophy type 1 on temporomandibular joint and dentofacial morphology: A CBCT analysis

Evlıce

Yüksel

Evlice

et al. 2023

J of Oral Rehabilitation

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The other face of facioscapulohumeral muscular dystrophy: Exploring orofacial weakness using muscle ultrasound

Vincenten,

van Doorn,

Teeselink

et al. 2024

Muscle and Nerve

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Introduction/AimsOne of the most distinct clinical features of facioscapulohumeral muscular dystrophy (FSHD) is facial weakness. It leads to diminished facial expression and functional impairments. Despite its clinical relevance, little else is known about orofacial muscle involvement. We therefore evaluated orofacial muscle involvement in a sizeable cohort of FSHD participants with muscle ultrasound.MethodsMuscle ultrasound images of the following orofacial muscles were scored visually and quantitatively: depressor anguli oris (DAO), orbicularis oris (OO), buccinator, temporalis, masseter, digastric, zygomaticus major and minor bilaterally, and the geniohyoid. Reliability analyses of both visual and quantitative evaluations were performed. Ultrasound results were correlated with other measures: the FSHD clinical score, facial weakness score, and facial function scale.ResultsWe included 107 FSHD participants (male 54%; age 52 ± 14 years), of whom 92% showed signs of facial weakness. The reliability of visual ultrasound analysis varied widely (κ 0.0–1.0). Quantitative ultrasound reliability was high (intraclass correlation analysis ≥ 0.96). The DAO, buccinator, OO, temporalis, and zygomaticus minor muscles were affected most often (15%–39%). The digastric, geniohyoid, zygomaticus major, and masseter muscles were least often affected (<5%). The ultrasound compound score correlated weakly to moderately with other outcome measures used (ρ = 0.3–0.7).DiscussionThis study adds to the understanding of orofacial weakness in FSHD, confirming the involvement of the muscles of facial expression in FSHD using ultrasound. We showed that orofacial muscle ultrasound is feasible and reliable when quantitatively assessed. Future studies should evaluate orofacial muscle ultrasound longitudinally, alongside clinical and patient‐reported facial weakness outcome measures, to assess their potential as outcome measures.

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A Review of Muscular Dystrophies

Hoang,

Dowdy

2024

Anesthesia Progress

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Muscular dystrophy encompasses a group of genetic conditions with progressive muscle damage and weakness. Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X-linked recessive disorders that affect the production of the protein dystrophin. Emery-Dreifuss muscular dystrophy (EDMD) is typically an X-linked-recessive disorder involving the gene that codes for emerin. Facioscapulohumeral muscular dystrophy and oculopharyngeal muscular dystrophy (OPMD) are both autosomal dominant disorders. Although commonly mistaken as a condition in which patients are susceptible to malignant hyperthermia with volatile inhalational anesthetics, muscular dystrophy is more closely associated with rhabdomyolysis. Providers developing an anesthetic plan for dental patients with muscular dystrophy must take into consideration the patient’s baseline cardiac and pulmonary function as well as the potential for abnormalities. Nondepolarizing neuromuscular blocker use is safe but likely to result in prolonged skeletal muscle relaxation. Succinylcholine and volatile anesthetics are generally contraindicated due to the risks of rhabdomyolysis and hyperkalemia with subsequent ventricular fibrillation, cardiac arrest, and death if left untreated. In-depth understanding of the more commonly encountered forms of muscular dystrophy is vital to providing safe and effective ambulatory anesthesia care for patients undergoing dental treatment outside the traditional hospital operating room setting.

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Orofacial Manifestations Associated with Muscular Dystrophies: A Review

Cited by 9 publications

References 51 publications

The effect of myotonic dystrophy type 1 on temporomandibular joint and dentofacial morphology: A CBCT analysis

The effect of myotonic dystrophy type 1 on temporomandibular joint and dentofacial morphology: A CBCT analysis

The other face of facioscapulohumeral muscular dystrophy: Exploring orofacial weakness using muscle ultrasound

A Review of Muscular Dystrophies

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