Orofacial granulomatosis presenting as persistent lip swelling: Review of 6 new cases

El-Hakim, Michel; Chauvin, Peter J.

doi:10.1016/j.joms.2003.11.013

Cited by 63 publications

(54 citation statements)

References 16 publications

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“…[8] This swelling may affect one or both lips, causing lip hypertrophy (macrocheilia). The swelling is initially soft but becomes firmer with time as fibrosis ensues.…”

Section: Discussionmentioning

confidence: 99%

“…[2] A subset, granulomatous cheilitis, also called Miescher's cheilitis is a rare, idiopathic, inflammatory disorder which usually affects young adults, clinically manifesting as persistent, diffuse, non-tender, soft-to-firm swelling of one or both lips with the estimated incidence of 0.08 % in the general population. [3] It was described by Miescher in 1945, as an oligosymptomatic form of Melkersson-Rosenthal syndrome [4], which includes facial palsy and a plicated tongue. The exact etiology of granulomatous cheilitis is not known.…”

Section: Introductionmentioning

confidence: 99%

“…[7] Histopathologically, it shows granulomas consisting of lymphocytes and epithelioid histocytes with dilated lymphatics in lamina propria and perivascular aggregation of histocytes and plasma cells. [8] Management of granulomatous chelitis is dependent on its etiology. There is no accepted protocol for treatment of granulomatous cheilitis and available therapeutic options provide only limited and temporary remission.…”

Section: Introductionmentioning

confidence: 99%

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Granulomatous chelitis of the upper lip in a child

Khan

Agrawal

2016

Int J of Biomed & Adv Res

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Granulomatous cheilitis is a chronic granulomatous inflammatory condition involving the lips with a multifactorial etiology. The difficulty in treatment of granulomatous cheilitis is reflected in various treatments that have been tried and the lack of consensus regarding the preferred treatment. Combined therapy of intralesional corticosteroid and clofazimine or dapsone is one of the most commonly used treatments for the condition. Other treatment options are prednisone,antibiotics such as metronidozole,tetracycline hydroxychloroquine, sulfasalazine, antihistamines, macrolides, thalidomide and infliximab. However, therapeutic responses of patients with granulomatous cheilitis are often unpredictable and spontaneous recurrences are not uncommon .Therefore, an oral physician must carefully proceed in order to develop an accurate treatment planning. Management considerations for these patients depend upon the results of the investigations, patient's esthetic considerations and severity of the condition. A case of a nine year old child with the granulomatous cheilitis of upper lip who showed an excellent response to intalesional steroids, metronidazole and doxycycline, a combined therapeutic regimen is reported here.

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“…[8] This swelling may affect one or both lips, causing lip hypertrophy (macrocheilia). The swelling is initially soft but becomes firmer with time as fibrosis ensues.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Granulomatous chelitis of the upper lip in a child

Khan

Agrawal

2016

Int J of Biomed & Adv Res

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“…Ce signe est de moins en moins considéré comme un symptôme majeur de la triade classique, mais plutôt comme un signe en faveur du SMR [5] . Cet aspect est retrouvé chez 10% de la population [12] . Dans la famille étudiée, 14 personnes sur 20 présentent une langue plicaturée dont 8 cas isolés qui ne peuvent donc pas être reliés formellement au SMR.…”

Section: Commentairesunclassified

“…Quant au diagnostic de la tuberculose, l'intra-dermoréaction à la tuberculine et la radiographie pulmonaire sont des examens complémentaires capitaux [9] . La macrochéilite de Miesher est considérée, par la plupart des auteurs, comme une forme monosymptomatique de SMR [12] . Wiesenfeld et coll.…”

Section: Commentairesunclassified

Syndrome de Melkersson-Rosenthal à caractère familial : à propos d’un cas

Hentati¹,

Hammami

Oualha³

et al. 2008

Med Buccale Chir Buccale

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RÉSUMÉUn patient âgé de 18 ans consulte pour une macrochéilite supérieure évoluant par poussées sans que la lèvre reprenne son aspect normal entre les poussées. L'anamnèse révèle un antécédent de paralysie faciale péri-phérique gauche. L'examen endobuccal montre entre autres une langue plicaturée et un oedème gingival. Devant cette triade symptomatique, le diagnostic clinique du syndrome de Melkersson-Rosenthal a été éta-bli. La récidive de l'oedème a soulevé des difficultés thérapeutiques. L'enquête auprès de la famille du patient a permis d'établir l'arbre généalogique permettant de retrouver ces atteintes chez certains membres de cette famille. Med Buccale Chir Buccale 2007 ; 13 : 29-34. mots clés : syndrome de Melkersson-Rosenthal, paralysie faciale, oedème, granulomatose.

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