Orofacial Granulomatosis in Spain

Caus, J. Marcoval

doi:10.1016/j.adengl.2012.12.001

Cited by 1 publication

(2 citation statements)

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“…It was first described in 1985 by Weisenfeld as “the specific histology finding of granulomas in mucosal or skin biopsies taken from the mouth or face in the absence of a recognised systemic condition known to cause granulomas.”5 The granulomas are non-caseating and lymphoedema is also seen 6. The cause is unknown; however, there are theories about a genetic predisposition, infection and allergic triggers such as cinnamon, benzoates and even chocolate.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that this condition could be an early manifestation of Crohn's disease but there is no consensus on whether this is the underlying cause 3. Of note, a study has shown that patients with this condition in Spain do not seem to develop Crohn's disease 6. To add to the diagnostic challenge, similar symptoms can be seen in other granulomatous conditions such as tuberculosis and sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent lip swelling: a diagnostic challenge

et al. 2014

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A Caucasian woman in her late 20s was referred to the allergy/chest clinic by her general practitioner with an 8-month history of recurrent facial angio-oedema. She had no history of urticaria or airways symptoms and denied any similar problems previously. She had no family history of similar illness and was not on any regular medications. There was no history of atopy. Initially, a clinical diagnosis of idiopathic angio-oedema was made. Despite being treated with several antihistamines with doses equivalent to 40 mg of cetirizine/day, her problem had failed to respond satisfactorily. Later on, she also revealed history of intermittent gastrointestinal symptoms such as abdominal pain and diarrhoea. Routine investigations were unremarkable. The patient was referred to a dermatology clinic and a diagnosis of orofacial granulomatosis was suggested: a rare granulomatous disease presenting with lip enlargement, which may or may not be associated with Crohn's disease. A biopsy of the oral mucosa was consistent with this diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%