Orofacial Cleft Frequency Differences Depending on Geographic Origin: Coast vs. Inland

Vieira, Alexandre R.; Furtado, Paulo Germano Cavalcanti; Filho, Valdécio Vasconcelos Lacerda; Pereira, Jéssica Amorim Teotônio; Tenório, Isabelle Silvério; Luna, André Macedo; Filgueiras, Vitor Marques; Lacerda, Rosa Helena Wanderley

doi:10.3389/fdmed.2021.670948

Cited by 2 publications

(1 citation statement)

References 12 publications

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“… 26 This discrepancy in phenotype may be attributable to the multiple causes of NS CL/P, as well as the effects of maternal folate consumption during pregnancy on embryogenesis and fetal phenotype regulation due to epigenetic mechanisms. 27 28 With The advanced technology in molecular biology such as next-generation sequencing for trio analysis (child, mother, and father) probably can explain the inherited recessive alleles. Therefore, further study to analyze possible pathogenic variants in CLP cases is warranted.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Consanguinity as Risk Factor of Nonsyndromic Cleft Lips with or without Palate

Rochmah,

Harumsari,

Christiono

et al. 2023

Eur J Dent

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Objectives The etiologies of nonsyndromic cleft lips with or without palate (NS CL/P) are multifactorial, which include consanguineous marriages. The incidence of NS CL/P is relatively high in Indonesia notably in one of Indonesia's tribes whose members frequently marry close cousins. Thus, the purpose of this study is to analysis consanguinity as risk factor of NS CL/P in Sasak tribe, East Lombok, Indonesia Materials and Methods An observational analysis was made of a collected database of NS CL/P patients treated in social services in regency hospital of Dr. Soejono Selong, East Lombok, Indonesia. Demographic data such as age, gender, address (urban/rural), parent's education, presence or absence of consanguinity, type of clefts, and a three-generation pedigree were collected by interview and hospital medical record. Before analysis, patient information was anonymized and deidentified. From 2016 to 2018, each of 100 cleft and normal subjects with their Sasak parent were audited. The risk factors were analyzed statistically using odds ratio (OR) and chi-squared test. Results Consanguineous marriages identified 54 cases (54%), and 10 cases (10%) out of a total each 100 NS CL/P and controls, respectively. The majority of consanguinity (53.7%) was discovered in marriages between first cousins. NS CL/P cases were statistically linked (p = 0.00) with consanguineous marriages (OR: 10; 95% confidence interval: 1.6–3.1); in which the most prevalent case is unilateral cleft lips. Conclusion Consanguineous marriage increases the risk of NS CL/P in Sasak tribe, East Lombok, Indonesia. The development of strategies to educate communities on the impacts of culture-consanguineous marriage is required. The genetic inheritance from their ancestor may be responsible for the increased incidence of NS CL/P.

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Section: Discussionmentioning

confidence: 99%

Analysis of Consanguinity as Risk Factor of Nonsyndromic Cleft Lips with or without Palate

Rochmah,

Harumsari,

Christiono

et al. 2023

Eur J Dent

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Coast-or Inland Residence and Differences in the Occurrence of Cleft Lip and Cleft Palate

da Silva,

de Lavôr,

Freitas

et al. 2023

The Cleft Palate Craniofacial Journal

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Objetive To analyze if differences in lifestyle and environment between coastal and inland areas are associated with differences in frequency of orofacial cleft types. Design Populational cross-sectional study. Setting All live borns with orofacial cleft registered at Brazilian Live Birth Information System between 1999 and 2020. Participants 33,699 live borns with orofacial cleft. Intervention Data from borns with orofacial cleft were collected at Brazilian Live Birth Information System. Main outcome measure Differences in frequencies between the cleft types and covariates were determined using chi-square. Bivariate analysis was done to obtain the prevalence ratio of types of clefts by geographic origin. Multiple logistic regression analysis was used to determine adjusted odds ratios, controlling for covariates, establishing a significance level of p value <0.05. Results The frequency of cleft types was statistically significant different according to geographic origin (inland x coast). For syndromic clefts, the prevalence ratio for cleft lip with/without palate was 3.6 times higher inland (p value = 0.000). Regarding non-syndromics, the prevalence ratio for cleft lip with/without palate was two times higher inland (p value = 0.000). Logistic regression suggested cleft lip with/without palate was 6.33 more likely to occur in inland regions (p value = 0.000). Conclusion Geographic origin was associated with the type of cleft in Brazil, with a higher prevalence of cleft lip with/without palate in inland areas, compared to cleft palate, which was higher in the coast.

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Orofacial Cleft Frequency Differences Depending on Geographic Origin: Coast vs. Inland

Cited by 2 publications

References 12 publications

Analysis of Consanguinity as Risk Factor of Nonsyndromic Cleft Lips with or without Palate

Analysis of Consanguinity as Risk Factor of Nonsyndromic Cleft Lips with or without Palate

Coast-or Inland Residence and Differences in the Occurrence of Cleft Lip and Cleft Palate

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