Orodispersible tablets of meloxicam using disintegrant blends for improved efficacy

Swamy, P. V.; Areefulla, SH; Shirsand, SB; Gandra, Smitha; Prashanth, B

doi:10.4103/0250-474x.39448

Cited by 18 publications

(14 citation statements)

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“…This negative effect may be due to the formation of a viscous gel layer by CCS and SSG which may impede further penetration of the disintegration medium and hindered the disintegration of tablets. 24,25) The obtained results were similar to the findings of Khan et al 26) and Patel et al…”

Section: Effect Of Type and Concentration Of Superdisintegrantsupporting

confidence: 90%

Formulation and Optimization of Orally Disintegrating Tablets of Sumatriptan Succinate

Sheshala

Khan

Darwis

2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Section: Effect Of Type and Concentration Of Superdisintegrantsupporting

confidence: 90%

Formulation and Optimization of Orally Disintegrating Tablets of Sumatriptan Succinate

Sheshala

Khan

Darwis

2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…On the contrary, when the concentration of CCS and SSG was increased, it had a negative effect on the disintegration of the tablets. This negative effect may be due to the formation of a viscous gel layer by CCS and SSG which may impede further penetration of the disintegration medium and hinder the disintegration of tablet contents (Swamy et al, 2007;Setty et al, 2008). Moreover, at the same concentration level, the disintegration time of the tablets formulated using crospovidone was lower than those containing CCS and SSG.…”

Section: In Vitro Disintegration Timementioning

confidence: 96%

“…Their major advantage is that they can be taken without water at any time, which is ideal for pediatric and geriatric patients. Further, increased bioavailability and good stability make ODTs the dosage form of choice in the current market (Swamy et al, 2007;Patel and Patel, 2008). From the perspective of industry, ODTs may provide new business opportunities in the form of product differentiation, patent life extension and cost effective drug development (Battu et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Formulation and in vivo evaluation of ondansetron orally disintegrating tablets using different superdisintegrants

et al. 2011

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The aim of this study was to formulate cost effective taste-masked orally disintegrating tablets of ondansetron, a bitter drug using different superdisintegrants by a wet granulation technique. Microcrystalline cellulose (Avicel) as a diluent and disintegrant in addition to aspartame as a sweetener were used in all formulations. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, drug content, water content, in vitro disintegration time and in vitro drug release. The tablets' hardness was maintained in the range of 2-3 kg and friability was <1% for all batches. All tablet formulations disintegrated rapidly in vitro within 5.83 to 33.0 sec. The optimized formulation containing 15% Polyplasdone XL-10 released more than 90% of drug within 5 min and the release was comparable to that of a commercial product. In human volunteers, optimized formulation was found to have a pleasant taste and mouth feel and they disintegrated in the oral cavity within 12 sec. The stability results were also satisfactory. A pharmacokinetic study with the optimized formulation was performed in comparison with a reference (Zofer MD 8®) and they were found to be bioequivalent. In conclusion, a cost effective ondansetron orally disintegrating tablet was successfully prepared with acceptable hardness, desirable taste and rapid disintegration in the oral cavity.

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“…Drug content for ORD tablet was done by the assay method. 15,16 First the prepared tablet (2 mg API) was crushed and added to 10 ml of phosphate buffer pH 6.8. After 30 min the solution was filtered 17 and from 10 ml solution 1ml solution was withdrawn diluted up to 20 ml with phosphate buffer pH 6.8(10 µg/ml).…”

Section: Drug Contentmentioning

confidence: 99%

Formulation and Evaluation of Orodispersible Tablets of Granisetron Hydrochloride Using Agar as Natural Super disintegrants

Sahoo

Sahoo²,

Sahu³

et al. 2016

PHME

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The main aim of the study was to develop orodispersible tablets of Granisetron hydrochloride a selective 5-HT3 receptor antagonist (an antivomiting agent) for improving patient compliance, especially those of paediatric and geriatric categories with difficulties in swallowing. In the wet granulation method orodispersible (ORD) tablets were prepared using natural super disintegrants Agar agar. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, in vitro dispersion time, drug content and in vitro dissolution studies. The tablet formulation batch F4 was considered as the overall best formulation (with an in vitro drug release study of 99.09%). Short term stability studies (at 40 ± 2ºC/75 ± 5% RH) on the best formulation indicated that there no significant changes in drug content. From the FTIR study indicated that there are no drug excipient interactions.

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Orodispersible tablets of meloxicam using disintegrant blends for improved efficacy

Cited by 18 publications

References 0 publications

Formulation and Optimization of Orally Disintegrating Tablets of Sumatriptan Succinate

Formulation and Optimization of Orally Disintegrating Tablets of Sumatriptan Succinate

Formulation and in vivo evaluation of ondansetron orally disintegrating tablets using different superdisintegrants

Formulation and Evaluation of Orodispersible Tablets of Granisetron Hydrochloride Using Agar as Natural Super disintegrants

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