Orobol from enzyme biotransformation attenuates<i>Dermatophagoides farinae</i>-induced atopic dermatitis-like symptoms in NC/Nga mice

Lee, Chang Hyung; Yang, Hee Seok; Park, Jung Han Yoon; Kim, Jong-Eun; Lee, Ki Won

doi:10.1039/d1fo04362e

Cited by 1 publication

(1 citation statement)

References 44 publications

(49 reference statements)

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“…This murine strain need to irritate their skin by reapplied allergens to totally develop AD, so we applicate chemical substance SDS and HDM allergen. Among HDM allergens, we applied Dermatophagoides farinae to this experiment as an AD inducer, the most commonly used aeroallergens 23 , 24 . This allergen is known to cause various allergic inflammatory diseases by triggering pro-inflammatory mediators via MAPKs, IκB, or STATs pathways 24 .…”

Section: Discussionmentioning

confidence: 99%

Anti-atopic dermatitis effect of fish collagen on house dust mite-induced mice and HaCaT keratinocytes

Kim,

Jin,

Lee

et al. 2023

Sci Rep

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Collagen, a major structural protein in mammalian tissues, is effective against skin wounds and osteoarthritis. Although bovine and porcine collagens have mainly been used, several potential risks of mammalian collagen have led to the use of fish collagen (FC) as an alternative. FC and its peptides are used as common cosmeceutical products because of their antihypertensive, anti-bacterial, and antioxidant activities. Despite the effects of FC on wrinkle reduction, UV-protection, and wound healing, the relationship between FC and atopic dermatitis (AD) has not yet been reported. Therefore, we investigated the anti-AD effects of FC against house dust mite (Dermatophagoides farinae, HDM)-induced AD in NC/Nga mice and TNF-α/IFN-γ-stimulated HaCaT keratinocytes. FC alleviated AD apparent symptoms, such as dermatitis score, transepidermal water loss, epidermal thickness, and mast cell infiltration upon declining pro-inflammatory cytokines and mediators, IL-6, IL-5, IL-13, TSLP, and TNF-α. The skin barrier protein, filaggrin, was also recovered by FC administration in vivo and in vitro. Immune response and skin barrier dysfunction are both mitigated by three routes of FC administration: oral, topical, and both routes via the regulation of IκB, MAPKs, and STATs pathways. In summary, FC could be a potential therapeutic agent for AD by regulating immune balance and skin barrier function.

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Section: Discussionmentioning

confidence: 99%

Anti-atopic dermatitis effect of fish collagen on house dust mite-induced mice and HaCaT keratinocytes

Kim,

Jin,

Lee

et al. 2023

Sci Rep

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show abstract

Orobol from enzyme biotransformation attenuatesDermatophagoides farinae-induced atopic dermatitis-like symptoms in NC/Nga mice

Abstract: Orobol, a metabolite of genistein, is rare in natural soybean. It was found to have strong preventive and curative effects on AD in animal and cell models, and is superior to the natural isoflavone, genistein.

Cited by 1 publication

References 44 publications

Anti-atopic dermatitis effect of fish collagen on house dust mite-induced mice and HaCaT keratinocytes

Anti-atopic dermatitis effect of fish collagen on house dust mite-induced mice and HaCaT keratinocytes

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