Ornidazole suppresses CD133+ melanoma stem cells via inhibiting hedgehog signaling pathway and inducing multiple death pathways in a mouse model

Evyapan, Gülşah; Lüleyap, Ümit; Kaplan, Halil Mahir; Kara, İsmail Oğuz

doi:10.3325/cmj.2022.63.461

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…It must be noted that the methodology used to measure the effects on cellular proliferation by us and that used by DepMap for their chemical-perturbation viability screens is very different, and may require additional refinements/re-assessments to determine if ornidazole could be repurposed (maybe in combination with standard chemotherapy) in NSCLC. Moreover, a recent study in melanoma suggests that ornidazole could play a role in suppressing CD133+ stem cells [ 71 ], and CD133+ is commonly expressed in NSCLC [ 72 , 73 ], and be a potential novel target [ 74 , 75 ].…”

Section: Discussionmentioning

confidence: 99%

“… Given the limited effects of ornidazole when tested as a “stand-alone” agent, combinatorial treatments of standard NSCLC therapies with ornidazole are warranted to assess if this agent can either enhance therapy or resensitize resistant cells to therapy, or affect the expression of checkpoint inhibitor targets. Studies to assess whether ornidazole can affect cancer stem cell populations in NSCLC are warranted given the data emerging from melanoma [ 71 ]. In this regard, it may be possible to test this in a panel of isogenic parent/cisplatin-resistant cell lines which we have previously generated and shown to be enriched for CD133+ cells [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies to assess whether ornidazole can affect cancer stem cell populations in NSCLC are warranted given the data emerging from melanoma [ 71 ]. In this regard, it may be possible to test this in a panel of isogenic parent/cisplatin-resistant cell lines which we have previously generated and shown to be enriched for CD133+ cells [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

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An Analysis of JADE2 in Non-Small Cell Lung Cancer (NSCLC)

Murphy,

Gornés Pons,

Keogh

et al. 2023

Biomedicines

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The JADE family comprises three members encoded by individual genes and roles for these proteins have been identified in chromatin remodeling, cell cycle progression, cell regeneration and the DNA damage response. JADE family members, and in particular JADE2 have not been studied in any great detail in cancer. Using a series of standard biological and bioinformatics approaches we investigated JADE2 expression in surgically resected non-small cell lung cancer (NSCLC) for both mRNA and protein to examine for correlations between JADE2 expression and overall survival. Additional correlations were identified using bioinformatic analyses on multiple online datasets. Our analysis demonstrates that JADE2 expression is significantly altered in NSCLC. High expression of JADE2 is associated with a better 5-year overall survival. Links between JADE2 mRNA expression and a number of mutated genes were identified, and associations between JADE2 expression and tumor mutational burden and immune cell infiltration were explored. Potential new drugs that can target JADE2 were identified. The results of this biomarker-driven study suggest that JADE2 may have potential clinical utility in the diagnosis, prognosis and stratification of patients into various therapeutically targetable options.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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An Analysis of JADE2 in Non-Small Cell Lung Cancer (NSCLC)

Murphy,

Gornés Pons,

Keogh

et al. 2023

Biomedicines

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Ornidazole Inhibits the Angiogenesis and Migration Abilities of Non-small Cell Lung

Evyapan,

Senturk,

Celik

2024

Cell Biochem Biophys

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Unveiling the Dynamic Interplay between Cancer Stem Cells and the Tumor Microenvironment in Melanoma: Implications for Novel Therapeutic Strategies

Limonta,

Chiaramonte,

Casati

2024

Cancers

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Cutaneous melanoma still represents a significant health burden worldwide, being responsible for the majority of skin cancer deaths. Key advances in therapeutic strategies have significantly improved patient outcomes; however, most patients experience drug resistance and tumor relapse. Cancer stem cells (CSCs) are a small subpopulation of cells in different tumors, including melanoma, endowed with distinctive capacities of self-renewal and differentiation into bulk tumor cells. Melanoma CSCs are characterized by the expression of specific biomarkers and intracellular pathways; moreover, they play a pivotal role in tumor onset, progression and drug resistance. In recent years, great efforts have been made to dissect the molecular mechanisms underlying the protumor activities of melanoma CSCs to provide the basis for novel CSC-targeted therapies. Herein, we highlight the intricate crosstalk between melanoma CSCs and bystander cells in the tumor microenvironment (TME), including immune cells, endothelial cells and cancer-associated fibroblasts (CAFs), and its role in melanoma progression. Specifically, we discuss the peculiar capacities of melanoma CSCs to escape the host immune surveillance, to recruit immunosuppressive cells and to educate immune cells toward an immunosuppressive and protumor phenotype. We also address currently investigated CSC-targeted strategies that could pave the way for new promising therapeutic approaches for melanoma care.

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Ornidazole suppresses CD133+ melanoma stem cells via inhibiting hedgehog signaling pathway and inducing multiple death pathways in a mouse model

Cited by 3 publications

References 51 publications

An Analysis of JADE2 in Non-Small Cell Lung Cancer (NSCLC)

An Analysis of JADE2 in Non-Small Cell Lung Cancer (NSCLC)

Ornidazole Inhibits the Angiogenesis and Migration Abilities of Non-small Cell Lung

Unveiling the Dynamic Interplay between Cancer Stem Cells and the Tumor Microenvironment in Melanoma: Implications for Novel Therapeutic Strategies

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