Ornidazole-based sequential therapy is not effective in Helicobacter pylori eradication in children

Meta‐analysis: sequential therapy for Helicobacter pylori eradication in children

“…Of the included studies, 10 RCTs met the inclusion criteria . However, only five were full‐text publications; the remaining five trials were published only in abstract form . Except one publication in Chinese that was translated, all trials were published in English.…”

“…In almost all the studies, the standard triple therapy consisted of a PPI (omeprazole or lansoprazole) and two or three antibiotics. In almost all the included trials, clarithromycin was one of the antibiotics used.…”

“…In five out of 10 RCTs, the duration of triple therapy was 7 days . In the remaining studies, the duration of triple therapy ranged from 5 days through 10 days to 14 days . Except for one RCT, all were two‐armed studies.…”

“…Except for one RCT, all were two‐armed studies. The sequential therapy consisted of a PPI (omeprazole or lansoprazole) and amoxicillin administered for the first 5 days or 7 days, and then a PPI and two antibiotics administered for the next 5 or 7 days . In one RCT, the time of administration of the PPI was extended to 30 days .…”

Helicobacter pylori Infection in Children. Antimicrobial Resistance and Treatment Response

“…Given these resistance rates, the use of antibiograms to guide treatment is advisable. In children whose treatment included antimicrobials susceptible to the strain causing the infection, the eradication rate was 78.7%: although this percentage was lower than that achieved in adults , it was similar to that obtained in many other child populations . This failure could have been due to poor compliance with the prescribed regimen or to the development of antimicrobial resistance during treatment.…”