Orlistat increases serum paraoxonase activity in obese patients

Audikovszky, Mária; Pados, Gyula; Serés, I.; Harangi, Mariann; Fülöp, Péter; Katona, Evelin; Illyés, László; Winkler, Gábor; Katona, Éva; Paragh, György

doi:10.1016/j.numecd.2006.03.004

Cited by 33 publications

(20 citation statements)

References 26 publications

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“…Recent studies have shown that PON-1, a protective enzyme for LDL-C oxidation, is an important molecule in the pathogenesis of atherosclerosis (25). PON-1 has been studied in MetS and obesity in several studies in different study groups, and the results of these studies are conflicting (18,(26)(27)(28). Senti et al showed that PON activity is lower in MetS compared to controls, and they suggested that the increased oxidative stress is related with the low PON activity (18).…”

Section: Discussionmentioning

confidence: 99%

Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation

Tabur¹,

Torun²,

Sabuncu³

et al. 2010

European Journal of Endocrinology

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Objective: Paraoxonase-1 (PON-1), which has PON and arylesterase activities, is a high-density lipoprotein (HDL)-bound antioxidant enzyme that inhibits atherosclerosis. Diabetes has been shown to have an impact on oxidative stress. The effect of metabolic syndrome (MetS) on oxidative stress and PON-1 has been shown before, and PON-1 has been found to be related with accelerated atherogenesis. This study aimed to determine the oxidative state and PON and arylesterase activities in non-diabetic MetS and non-MetS obese patients. Design: Thirty obese patients (3 M and 27 F) without MetS, 40 non-diabetic obese patients (3 M and 37 F) with MetS, and 30 controls (2 M and 28 F) were enrolled. Methods: A 75 g glucose tolerance test was performed. PON-1, PON, arylesterase, total antioxidant status (TAS), high-sensitive C-reactive protein (hsCRP), and metabolic parameters were analyzed. Results: PON and arylesterase activities were similar between the groups, while TAS was low in both MetS and obese groups compared to controls (P!0.01 and P!0.05 respectively). CRP was higher in the MetS group compared with the obese and control groups (P!0.01 and P!0.001 respectively). In both the obese and MetS groups, CRP showed a positive correlation with body mass index (BMI). TAS was negatively correlated with BMI, waist circumference, triglyceride levels, and systolic and diastolic blood pressures (P!0.001). Conclusions: Oxidative stress is altered in non-diabetic MetS and non-MetS obese patients, but PON and arylesterase activities seem not to be affected. This result may be due to the absence of diabetes, the most severe form of altered carbohydrate metabolism.

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Section: Discussionmentioning

confidence: 99%

Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation

Tabur¹,

Torun²,

Sabuncu³

et al. 2010

European Journal of Endocrinology

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“…Ferretti et al [11] demonstrated that there is increased oxidation of LDL-C and HDL-C, and low levels of paraoxonase activity in obese subjects compared with healthy individuals. The protective role of PON1 in obesity is also supported by an observed increase in paraoxonase activity and a decrease in body mass index (BMI) in obese patients who were prescribed orlistat (a drug designed to treat obesity) in addition to a reduced-calorie diet [2]. Another study reported that there are changes in the lactonase activity of PON1 in overweight and obese women after a reduced-calorie dietary plan, which is reflected in a reduction in BMI and a significant reduction in LDL-C levels [20].…”

Section: Introductionmentioning

confidence: 99%

Relationship between the paraoxonase (PON1) L55M and Q192R polymorphisms and obesity in a Mexican population: a pilot study

et al. 2011

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The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and representing both sexes. Based on body mass index, 63 individuals were classified as obese and 64 as normal weight. The PON1-Q192R and PON1-L55M polymorphisms were determined by restriction fragment length polymorphism PCR analysis. Both arylesterase and paraoxonase activity levels were similar in both groups, whereas systolic pressure, triglyceride, total cholesterol, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, glucose, and insulin levels were higher in the obese group than in the normal-weight group (P < 0.05). An exception was the high-density lipoprotein cholesterol (HDL-C) levels, which were lower in the obese group (P < 0.05). Although the PON1-Q192R polymorphism was not associated with either group, the frequency of the homozygous L genotype for the PON1-L55M polymorphism was higher in the obese group than in the normal-weight group (P < 0.05). In conclusion, this study established a positive association between the PON1-L55M homozygous L genotype and obesity.

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“…In one, weight loss by gastric banding significantly increased PON-1 activity in morbidly obese patients [10]. In another study with obese patients treated with orlistat (an anti-obesity drug), PON-1 activity was significantly increased [11]. Weight reduction via a combination of exercise and diet energy restriction significantly reduced PON-1 [12].…”

Section: Introductionmentioning

confidence: 99%

Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women

Kotani

Sakane

Sano

et al. 2009

J. Clin. Biochem. Nutr.

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Low caloric diet (LCD) is used for weight loss. Paraoxonase 1 (PON-1) is associated with the antioxidant functions of high-density lipoprotein (HDL). Among limited data on the relationships between obesity and PON-1, there has been no study on the effects of a stand-alone LCD on the physiological lactonase activity of PON-1. We investigated the prospective effects of LCD intervention (2 months) for weight loss on serum PON-1 activities (lactonase, arylesterase [mono-esterase] and tri-esterase) and HDL cholesterol (HDL-C), and their association with low-density lipoprotein cholesterol (LDL-C) in overweight and non-morbidly obese but otherwise healthy women (n = 30; mean age, 50.3 years; mean body mass index [BMI], 28.5 kg/m2). In addition to the data such as BMI, blood pressure, blood glucose and lipids, PON-1 activities were examined between pre- and post-intervention. The intervention reduced all metabolic outcomes, and PON-1 lactonase activity (determined with 5-[thiobutyl]butyrolactone) significantly decreased by 6.1%, paralleled by arylesterase (by 7.3%) and tri-esterase (by 7.8%). In multiple regression analysis, the percent change of PON-1 lactonase was significantly, positively and independently correlated to that of LDL-C (β = 0.51), HDL-C (β = 0.40), and BMI (β = 0.37). Our results showed that the solo diet treatment on weight loss might reduce serum PON-1 lactonase activity with reduced HDL-C and LDL-C. The relationship between the lactonase and LDL-C may be adaptive, plausibly hypothesizing less need for PON-1 activity as an antioxidant property to protect lipoproteins. Further research is needed to confirm this prediction.

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Orlistat increases serum paraoxonase activity in obese patients

Cited by 33 publications

References 26 publications

Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation

Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation

Relationship between the paraoxonase (PON1) L55M and Q192R polymorphisms and obesity in a Mexican population: a pilot study

Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women

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