ORL1 receptor-mediated down-regulation of mPER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle

Miyakawa, Kazuko; Uchida, Ayumi; Shiraki, Tomomi; Teshima, Koji; Takeshima, Hiroshi; Shibata, Shigenobu

doi:10.1016/j.neuropharm.2006.11.003

Cited by 11 publications

(10 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, OPRL1 (also known as nociception receptor) is an opiate receptor that is strongly expressed in the mouse SCN where it binds nociception/orphanin FQ, which suppresses 88% of SCN neurons (41). Moreover, OPRL1 activation down-regulates PER2 in the SCN and accelerates reentrainment of rhythms following a shift in the light-dark cycle (42). The importance of the rhythms in this protein in BA11 and BA47 function in human brain is not known.…”

Section: Discussionmentioning

confidence: 99%

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Chen

Logan

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

225

219

View full text Add to dashboard Cite

With aging, significant changes in circadian rhythms occur, including a shift in phase toward a “morning” chronotype and a loss of rhythmicity in circulating hormones. However, the effects of aging on molecular rhythms in the human brain have remained elusive. Here, we used a previously described time-of-death analysis to identify transcripts throughout the genome that have a significant circadian rhythm in expression in the human prefrontal cortex [Brodmann’s area 11 (BA11) and BA47]. Expression levels were determined by microarray analysis in 146 individuals. Rhythmicity in expression was found in ∼10% of detected transcripts (P < 0.05). Using a metaanalysis across the two brain areas, we identified a core set of 235 genes (q < 0.05) with significant circadian rhythms of expression. These 235 genes showed 92% concordance in the phase of expression between the two areas. In addition to the canonical core circadian genes, a number of other genes were found to exhibit rhythmic expression in the brain. Notably, we identified more than 1,000 genes (1,186 in BA11; 1,591 in BA47) that exhibited age-dependent rhythmicity or alterations in rhythmicity patterns with aging. Interestingly, a set of transcripts gained rhythmicity in older individuals, which may represent a compensatory mechanism due to a loss of canonical clock function. Thus, we confirm that rhythmic gene expression can be reliably measured in human brain and identified for the first time (to our knowledge) significant changes in molecular rhythms with aging that may contribute to altered cognition, sleep, and mood in later life.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Chen

Logan

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

225

219

View full text Add to dashboard Cite

show abstract

“…In addition to VIP and AVP, which appear to play key roles in generating and maintaining circadian timing, other neuropeptides modify the activity of the SCN (Teshima et al. , 2005; Miyakawa et al. , 2007).…”

Section: Discussionmentioning

confidence: 99%

“…, 1996; Maywood et al. , 2007; Miyakawa et al. , 2007; Morin, 2007; Butler & Silver, 2009; Welsh et al.…”

Section: Introductionmentioning

confidence: 99%

“…Several neuropeptides, including vasoactive intestinal peptide (VIP), arginine vasopressin (AVP), pituitary adenylate cyclase-activating peptide (PACAP) and nociceptin ⁄ orphanin FQ (OFQ) have been shown to play important roles in the regulation of circadian clock function and entrainment (Piggins et al, 1996;Maywood et al, 2007;Miyakawa et al, 2007;Morin, 2007;Butler & Silver, 2009;Welsh et al, 2010). Calcium is important in the signal transduction pathways mediating photic entrainment, and is an essential component of the feedback loops that generate circadian rhythms (Albrecht et al, 1997;Shearman et al, 1997;Shigeyoshi et al, 1997;Morris et al, 1998;, yet currently little is known of the role that Ca 2+ plays in the neuropeptide regulation of the circadian clock.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuropeptide‐mediated calcium signaling in the suprachiasmatic nucleus network

Irwin

Allen

2010

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…This receptor is expressed in the rat and mouse SCN (Allen et al, 1999;Houtani et al, 2000), and systemic injection of W-212393, a NOP-1 agonist, dose dependently induces phase advances in body temperature rhythms in rats, and in locomotor activity rhythms in mice, when administered during the midsubjective day (Miyakawa et al, 2007;Teshima et al, 2005). However, injection of OFQ/N into the hamster SCN appears to be without effect (Allen et al, 1999).…”

Section: Other Mediatorsmentioning

confidence: 99%

Regulation of circadian rhythms in mammals by behavioral arousal.

Webb¹,

Antle²,

Mistlberger³

2014

Behavioral Neuroscience

View full text Add to dashboard Cite

Circadian rhythms in most mammals are synchronized to local time by phase and period resetting actions of daily light-dark cycles on a retino-recipient, light-entrainable circadian pacemaker, the suprachiasmatic nucleus (SCN). The SCN receives input from other brain regions, some of which mediate the phase and period resetting actions of behavioral arousal on circadian rhythms. We review historical milestones in the discovery of so-called "nonphotic" circadian clock resetting induced by environmentally stimulated arousal, or by feedback from clock-controlled rest-activity cycles. Topics include species generality, interactions between concurrent or successive photic and nonphotic inputs to the circadian clock, neural pathways, neurotransmitters, and clock cell responses that mediate resetting by behavioral arousal. The role of behavioral inputs to the circadian clock in determining the phase of entrainment to local time in natural environments is not well understood. Nonetheless, nonphotic effects are of sufficient magnitude to raise issues for the design of experiments in behavioral neuroscience (any procedure that is sufficiently arousing may alter the timing of circadian clocks that regulate dependent variables of primary interest). Nonphotic inputs to the clock may be exploited in strategies to reset or strengthen circadian rhythms in humans.

show abstract

ORL1 receptor-mediated down-regulation of mPER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle

Cited by 11 publications

References 49 publications

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Neuropeptide‐mediated calcium signaling in the suprachiasmatic nucleus network

Regulation of circadian rhythms in mammals by behavioral arousal.

Contact Info

Product

Resources

About