Origins ofde novochromosome rearrangements unveiled by coupled imaging and genomics
Marco Raffaele Cosenza,
Alice Gaiatto,
Büşra Erarslan Uysal
et al.
Abstract:Chromosomal instability results in widespread structural and numerical chromosomal abnormalities (CAs) during cancer evolution1-3. While CAs have been linked to mitotic errors resulting in the emergence of nuclear atypias4-7, the underlying processes and basal rates of spontaneous CA formation in human cells remain under-explored. Here we introduce machine learning-assisted genomics-and-imaging convergence (MAGIC), an autonomously operated platform that integrates automated live-cell imaging of micronucleated … Show more
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