Origins of Breath Nitric Oxide in Humans

Dillon, William C.; Hampl, Václav; Shultz, Pamela J.; Rubins, Jeffrey B.; Archer, Stephen L.

doi:10.1378/chest.110.4.930

Cited by 83 publications

(76 citation statements)

References 23 publications

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“…Ideally, the is constitutively produced by steroid-resistant nitric oxide synthase (NOS) [25,26], but not by nasal commensal bacteria, as there is no reduction in nasal NO after antibiotics [24,27]. Expression of NOS in normal human nasal mucosa [24,25] and upregulation of inducible NOS (iNOS) in perennial allergic rhinitis, however, might be the reason for the reduction in nasal NO after treatment with nasal glucocorticosteroids in normal subjects and patients with allergic rhinitis [24,28]. By contrast, nasal NO levels are low in cystic fibrosis [14,16,20] and Kartagener's syndrome [27], and this might be accountable for chronic infection in the upper airways of these patients.…”

Section: Ers Task Force Reportmentioning

confidence: 99%

See 1 more Smart Citation

Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force

Kharitonov¹,

Alving²,

Barnes³

1997

Eur Respir J

632

528

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Section: Ers Task Force Reportmentioning

confidence: 99%

“…High concentrations can also be detected in nasal air of normal subjects [5,10,13,[22][23][24]. The paranasal sinuses appear to be large contributors to this NO, which…”

Section: Introductionmentioning

confidence: 99%

Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force

Kharitonov¹,

Alving²,

Barnes³

1997

Eur Respir J

632

528

View full text Add to dashboard Cite

“…Plasma NO x concentration is used as a marker for endogenous NO production in humans . Another valid method of measurement of endogenous NO production is to assess the NO excreted in the exhaled air, detected by a chemiluminescence assay (Gustafsson et al, 1991;Kharitonov et al, 1997;Leone et al, 1994;Dillon et al, 1996;Archer et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary and Systemic Nitric Oxide Measurements During CCK-5-Induced Panic Attacks

Lara

Chrapko

Archer

et al. 2003

Neuropsychopharmacol

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Nitric oxide (NO) plays a major role in cardiopulmonary regulation as illustrated by the alterations of the NO system described in cardiopulmonary illnesses. Recent studies have found an association between panic disorder and cardiovascular death and illness, as well as pulmonary diseases. Our objective was to investigate whether pulmonary or systemic NO production was altered during induced panic attacks (PAs). We used a double-blind placebo-controlled crossover design with randomization of the order of an injection of placebo and pentagastrin, a cholecystokinin-B receptor agonist that induces PAs in healthy volunteers (HVs). A total of 17 HVs experienced a PA after pentagastrin challenge. Exhaled NO and NO metabolites were measured by chemiluminescence. During pentagastrin-induced PAs, HVs displayed significant decreases in plateau concentrations of NO exhaled, which were associated with proportional increases in minute ventilation. There were no significant changes in pulmonary or systemic NO production. These results suggest that the decrease in exhaled NO concentration observed during pentagastrin-induced PAs is related to the associated hyperventilation, rather than to any change in lung NO production. This study is the first to evaluate changes in NO measurements during acute anxiety.

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“…9,10 In vivo synthesis of NO occurs in the lungs in the vascular endothelium, epithelial cells, 11 nerve cells, 12 smooth muscle cells, and inflammatory cells such as macrophages. In addition, the cells of the upper airways, especially in the nose and paranasal sinuses, 13,[14][15][16][17] generate large amounts of NO, which is inhaled whenever the patient inspires through the nose.…”

mentioning

confidence: 99%

Inhaled nitric oxide in 2003: a review of its mechanisms of action

Wang

Kebir

Blaise

2003

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To review the pulmonary and systemic effects of endogenous nitric oxide and inhaled nitric oxide administered to patients.S So ou ur rc ce e: : A systematic search for experimental data, human case reports, and randomized clinical trials since 1980, the year of discovery of endothelium-derived relaxing factor. P Pr ri in nc ci ip pa al l f fi in nd di in ng gs s: : Nitric oxide has pulmonary and systemic effects. Inhaled nitric oxide not only causes selective pulmonary vasodilation but also results in pulmonary vasoconstriction of the vessels perfusing non-ventilated alveolae. The systemic effects of inhaled nitric oxide, which include modulation of the distribution of systemic blood flow, increase in renal output, interaction with coagulation, fibrinolysis and platelet functions, alteration of the inflammatory response, are described and the mechanisms of nitric oxide transport are explained. The possible toxicity of inhaled nitric oxide is also discussed.C Co on nc cl lu us si io on n: : The multiple effects of inhaled nitric oxide support its role as a pulmonary and extra-pulmonary medication.

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Origins of Breath Nitric Oxide in Humans

Cited by 83 publications

References 23 publications

Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force

Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force

Pulmonary and Systemic Nitric Oxide Measurements During CCK-5-Induced Panic Attacks

Inhaled nitric oxide in 2003: a review of its mechanisms of action

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