Origins of Anhedonia in Childhood and Adolescence

Prabhakar, Janani; Nielson, Dylan; Stringaris, Argyris

doi:10.1007/7854_2022_356

Cited by 5 publications

(6 citation statements)

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“…Understanding early‐onset anhedonia is an important future direction. As mentioned, anhedonia is rare before adolescence but can occur as early as age 3 (Prabhakar et al., 2022). Preschoolers' odds of having a depression diagnosis are substantially higher when the symptom of anhedonia is present, and children with anhedonia show greater sensitivity to stress (Luby et al., 2004).…”

Section: Evaluation Of the Evidence For The Proposed Modelmentioning

confidence: 99%

“…What is known is that Major Depressive Disorder (MDD) has a peak onset in adolescence (Avenevoli, Swendsen, He, Burstein, & Merikangas, 2015) and anhedonia has a high prevalence in adolescents with MDD (i.e., 65%–76%) (Lewinsohn, Petit, Joiner Jr., & Seeley, 2003; Yorbik, Birmaher, Axelson, Williamson, & Ryan, 2004). Anhedonia can occur as early as age 3 (Prabhakar, Nielson, & Stringaris, 2022), and is even observed in community samples of adolescents without a depressive disorder (Stringaris et al., 2015). Furthermore, epidemiological evidence suggests that 58% of adolescents with anhedonia report a depressive disorder later in life (Wilcox & Anthony, 2004).…”

Section: The Nature Of Anhedonia: Anhedonia Emergence and Clinical Co...mentioning

confidence: 99%

“…Preschoolers' odds of having a depression diagnosis are substantially higher when the symptom of anhedonia is present, and children with anhedonia show greater sensitivity to stress (Luby et al., 2004). Given the developmental importance of experiencing joy and pleasure during childhood, the emergence of anhedonia early on in development is thought to signal an increased likelihood of developing later, severe psychopathology (Prabhakar et al., 2022) while recurrent depression is the more likely outcome when depression emerges during adolescence (Harrington et al., 1990). Anhedonia could develop early in childhood, especially among children who have experienced child adversity.…”

Section: Evaluation Of the Evidence For The Proposed Modelmentioning

confidence: 99%

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Annual Research Review: Puberty and the development of anhedonia – considering childhood adversity and inflammation

Gupta,

Eckstrand,

Forbes

2024

Child Psychology Psychiatry

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Anhedonia, or diminished pleasure and motivation, is a symptom of severe mental illness (e.g., depressive disorder, bipolar disorder, schizophrenia) that emerges during adolescence. Anhedonia is a pernicious symptom that is related to social impairments, treatment resistance, and suicide. As the mechanisms of anhedonia are postulated to include the frontostriatal circuitry and the dopamine neuromodulatory system, the development and plasticity of these systems during the vulnerable period of adolescence, as well as their sensitivity to pubertal hormones, suggest that pubertal maturation could play a role in the development of anhedonia. This review takes a developmental perspective, considering the possibility that anhedonia emerges in the context of pubertal maturation and adolescent development, with childhood adversity and chronic inflammation influencing neural reward systems to accelerate anhedonia's progression. Here, we review the relevant extant literature on the components of this model and suggest directions for future research.

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Section: Evaluation Of the Evidence For The Proposed Modelmentioning

confidence: 99%

Section: The Nature Of Anhedonia: Anhedonia Emergence and Clinical Co...mentioning

confidence: 99%

Section: Evaluation Of the Evidence For The Proposed Modelmentioning

confidence: 99%

See 1 more Smart Citation

Annual Research Review: Puberty and the development of anhedonia – considering childhood adversity and inflammation

Gupta,

Eckstrand,

Forbes

2024

Child Psychology Psychiatry

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“…Dysfunctions in hedonic processing are seen across a multitude of neuropsychiatric disorders including schizophrenia, major depressive disorder, bipolar disorder, substance use disorder, and personality disorders (American Psychiatric Association, 2013;Lambert et al, 2018;Pizzagalli, 2022;Whitton & Pizzagalli, 2022). Additionally, deficits in hedonic processing have been reported in adolescents and children as young as three years old which highlights the need for studies across lifespan development (National Institute of Mental Health, 2023;Prabhakar et a., 2022). To understand dysfunctions in hedonic processing and their potential underlying mechanisms, we need to examine the components involved in normal hedonic processing.…”

Section: An Introduction To Hedonic Processingmentioning

confidence: 99%

“…As discussed in Chapter 1, dysfunction in hedonic processing is seen across a variety of neuropsychiatric disorders, highlighting the need for research into the underlying mechanisms of hedonic processing (American Psychiatric Association, 2013; Prabhakar et al, 2022). This chapter explores the effects of a genetic reduction in D1R on both anticipatory and consummatory phases of hedonic processing.…”

Section: Introductionmentioning

confidence: 99%

Unravelling the Role of the Dopamine D1 Receptor in Anhedonia, Asociality, and Avolition

Witt

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Despite major advances in neuroscience, there has been limited progress in improving pharmacological treatment for neuropsychiatric disorders. Neuropsychiatric disorders are heterogenous with variance in symptoms within disorders and partial overlap in symptoms between disorders, leading to symptoms that remain untreated. To improve treatment outcomes, the Research Domain Criteria (RDoC) was created to provide researchers a framework for examining the neurobiological mechanisms underlying individual components, or dysfunctions, across disorders. Anhedonia, asociality and avolition are three excellent examples of prominent symptoms associated with poor functional outcome across disorders.This thesis aimed to use an RDoC approach to investigate the neurobiological mechanisms underlying anhedonia, asociality and avolition. To this aim, rats with a selective genetic reduction in the dopamine D1 receptor (DAD1-/- mutants) underwent a series of five studies across their lifespan that examined the role of the D1 receptor in anticipatory and consummatory pleasure, social play behaviour, socio-emotional communication, and motivation. Additionally, previous research with DAD1-/- mutants used only males; this thesis expanded on that work by including both sexes and explored the possibility for sex differences in each study. The overall hypothesis was that the D1 receptor is implicated in anticipatory anhedonia, asociality and avolition, therefore DAD1-/- mutant rats were predicted to exhibit reduced socio-emotional communication, anticipation of rewards, engagement in social play and exertion of effort across their lifespan. The results showed that genetic reduction in the dopamine D1 receptor led to blunted motivation and diminished anticipatory pleasure, while consummatory pleasure and social play were not impacted. There were marked sex differences in some measures such as stability of social play across sessions and exertion of effort. Ultimately, this thesis furthered pharmacological research, implicating a clear role for the dopamine D1 receptor in motivation and anticipatory pleasure which could be targeted for treatment. In addition, this thesis supported the vital importance of including both sexes in animal research to address the strong focus of males in neuroscience research and in the role of D1 receptors in general.

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