Origins and Consequences of Age at First Drink. I. Associations With Substance-Use Disorders, Disinhibitory Behavior and Psychopathology, and P3 Amplitude

Iacono, William G.; Legrand, Lisa N.; Malone, Steve; Elkins, Irene J.

doi:10.1097/00000374-200108000-00010

Cited by 124 publications

(164 citation statements)

References 43 publications

(21 reference statements)

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“…Data from the Minnesota Twin Family Study revealed that girls and boys who reported drinking before age 14 scored between .2 and .5 standard deviations above nondrinkers on teacher-rated measures of opposition, hyperactivity, impulsivity, and inattention (McGue, Iacono, Legrand, Malone, & Elkins, 2001). Findings from a sample of alcohol-abusing or alcohol dependent and comparison adolescents revealed significantly higher levels of selfreported impulsivity and aggression among both male and female problem drinkers (Solof et al, 2000).…”

Section: Behavioral Under-controlmentioning

confidence: 92%

Pathways to Adolescent Substance Use Among Sexually Abused Girls

Bailey

McCloskey

2005

J Abnorm Child Psychol

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This study examined the link between childhood sexual abuse and adolescent substance use among girls, and evaluated depressive self-concept and behavioral under-control (BUC) as pathways to substance use for sexually abused girls. Participants (n = 150) were drawn from a longitudinal study of the impact of domestic violence on the lives of women and children. Structural equation modeling revealed that girls' childhood sexual abuse was associated prospectively with their later substance use. This relationship persisted when age, co-occurring forms of child abuse (physical, exposure to domestic violence), childhood depression and aggression, family income, maternal substance use, and parenting practices were controlled. Behavioral under-control mediated the relationship between childhood sexual abuse and later substance use, but depressive self-concept did not. Implications, limitations, and directions for future research are discussed.

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Section: Behavioral Under-controlmentioning

confidence: 92%

Pathways to Adolescent Substance Use Among Sexually Abused Girls

Bailey

McCloskey

2005

J Abnorm Child Psychol

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“…Other risk factors may be in domains other than substance use. In this issue, McGue and colleagues extend their work on shared liability to substance use and externalizing in adolescence (e.g., McGue et al 2001) to examine the genetic and environmental overlap between problem behaviors in adolescence and risk for adult substance abuse. Dick and colleagues (this issue) describe how variation at a specific genetic locus (GA-BRA2) may influence conduct disorder in adolescence but alcohol and drug dependence in adulthood.…”

Section: Challenges For Genetic Research On Substance Usementioning

confidence: 99%

“…The papers reflect several themes, including genetic influences on stages of substance involvement (Pagan et al 2006;Lessem et al 2006;Neale et al 2006;VargasIrwin et al 2006), factors which predict adult substance related problems (Dick et al 2006;McGue et al 2006;Lessem et al 2006), and measurement and other methodological issues in substance abuse genetics (Crabbe et al 2006;Agrawal et al 2006;Pergadia et al 2006;Neale et al 2006). Five of the papers examine risk factors that extend across classes of substances (Lessem et al 2006;McGue et al 2006;Young et al 2006;Neale et al 2006;Dick et al 2006), whereas the others focus on a specific substance class, including alcohol (Pagan et al 2006;Crabbe et al 2006), tobacco Pergadia et al 2006), and cocaine (Vargas-Irwin et al 2006).…”

Section: Overview Of the Special Issuementioning

confidence: 99%

Challenges in Genetic Studies of the Etiology of Substance Use and Substance Use Disorders: Introduction to the Special Issue

2006

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Misuse of psychoactive substances is associated with substantial costs to users and to society. A growing literature suggests individual differences in vulnerability to develop substance related problems are influenced to a large degree by genetic factors. We review the evidence from genetic epidemiologic and molecular genetic studies of problematic use of alcohol, tobacco, and other drugs, then discuss the challenges for the next generation of studies of genetic influences on substance use. These challenges are addressed in the remaining papers of this special issue. The papers cover a variety of approaches, substances, and non-human as well as human studies, but are united by their focus on going beyond heritability estimates to address the mechanisms and processes underlying the development of substance use and substance related problems, including measurement, precursors of substance abuse, stages of substance involvement, and specificity of genetic influences.

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“…Although the development of substance use disorders (SUD) in adolescence is less prevalent, it is not rare (Kandel et al, 1997;Young et al, 2002), and early onset of use is a well-established risk factor for the progression from use to abuse and dependence (Bucholz et al, 2000;Chen and Anthony, 2003;Grant and Dawson, 1998). It has been argued that this trajectory may be a by-product of an underlying pattern of disinhibitory psychopathology rather than a direct risk (McGue et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Genetic and Environmental Vulnerabilities Underlying Adolescent Substance Use and Problem Use: General or Specific?

et al. 2006

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Are genetic and environmental risks for adolescent substance use specific to individual substances or general across substance classes? We examined this question in 645 monozygotic twin pairs, 702 dizygotic twin pairs, 429 biological sibling pairs, and 96 adoptive (biologically unrelated) sibling pairs ascertained from community-based samples, and ranging in age from 12 to 18 years. Substance use patterns and symptoms were assessed using structured psychiatric interviews. Biometrical model fitting was carried out using age- and sex-specific thresholds for (a) repeated use and (b) problem use, defined as one or more DSM-IV symptoms of abuse or dependence. We hypothesized that problem use would be more heritable than use in adolescence, and that both genetic and environmental risks underlying tobacco, alcohol, and marijuana use and problem use would be significantly correlated. Results of univariate analyses suggested significant heritable factors for use and problem use for all substances with the exception of alcohol use. Shared environmental factors were important in all cases and special twin environmental factors were significant for tobacco use, tobacco problem use, and alcohol use. Multivariate analyses yielded significant genetic correlations between each of the substances (for both levels studied), and significant shared environmental correlations among use variables only. Our results suggest that tobacco, alcohol, and marijuana problem use are mediated by common genetic influences, but shared environmental influences may be more substance-specific for problem use.

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Origins and Consequences of Age at First Drink. I. Associations With Substance-Use Disorders, Disinhibitory Behavior and Psychopathology, and P3 Amplitude

Cited by 124 publications

References 43 publications

Pathways to Adolescent Substance Use Among Sexually Abused Girls

Pathways to Adolescent Substance Use Among Sexually Abused Girls

Challenges in Genetic Studies of the Etiology of Substance Use and Substance Use Disorders: Introduction to the Special Issue

Genetic and Environmental Vulnerabilities Underlying Adolescent Substance Use and Problem Use: General or Specific?

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