Original use of the liquid nature of the stationary phase in counter-current chromatography

Optimization of the Fractionation and Recovery of Polyketide Antibiotics by Countercurrent Chromatography

“…1,3 In addition, there is continued interest in the application of CCC devices as a novel means of integrating reaction and separation steps. [4][5][6] In this work, we focus on the fractionation of a commercial erythromycin preparation consisting of a number of structurally similar analogues of the main product, erythromycin A (EA). Erythromycin is a macrolide antibiotic (MWt = 732 Da), produced commercially by large scale fermentation of the actinomycete, Sacchropolyspora erythrea.…”

Countercurrent Chromatography in Analytical Chemistry (IUPAC Technical Report)

“…alkylphenyl poly(oxyethylene) ethers (APEO) family, used in detergents, cleaners, and process aids, were successfully enriched from waste water on a Sanki CPC hydrostatic apparatus [78,79]. A concentration factor of 400 was achieved using ethyl acetate as stationary extracting phase.…”