2010
DOI: 10.5114/aoms.2010.13887
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Original research Genetic variability and the risk of myocardial infarction in Poles under 45 years of age

Abstract: IntroductionMyocardial infarction is caused by the obstruction of an artery in places of atherosclerosis plaque rupture. Endothelial cells during their activation express chemoattractant and adhesion molecules whereas infiltrating inflammatory cells produce enzymes, predisposing a lesion to rupture.Material and methodsWe investigated the correlation between polymorphisms in the human genes E-selectin (Ser128Arg), ICAM1 (K469E), OLR1 (K167N), MMP1 (1G/2G) and MMP3 (−1612 5A/6A) and the risk of MI in young Poles… Show more

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Cited by 34 publications
(28 citation statements)
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“…Some studies suggested genetic variability [47]. However, this favourable relationship disappears in older women (> 65 years).…”
Section: Discussionmentioning
confidence: 99%
“…Some studies suggested genetic variability [47]. However, this favourable relationship disappears in older women (> 65 years).…”
Section: Discussionmentioning
confidence: 99%
“…Almost 90% of (MI) cases are the result of an occlusive thrombosis in a coronary artery, occurring after the rupture of an atherosclerosis plaque (Sakowicz et al, 2010b). Consequently, a cascade of events follows: it begins with platelet aggregation, formation of thrombin and fibrin, and at last formation of the thrombus.…”
Section: Introductionmentioning
confidence: 99%
“…In addition to known risk factors for (MI), such as arterial hypertension, smoking, hypercholesterolemia, obesity, diabetes, sedentary, and alcohol consummation, the genetic contribution to heart diseases has been proved (Sakowicz et al, 2010b). As being polygenic, these disorders involve the contribution of more than one gene; they are genes involved in the inflammatory (endothelial Nitric Oxide Synthase, eNOS), coagulation (plasminogen activating inhibitor, PAI) and lipid (APO lipoprotein A5, APOA5) pathways.…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have identified that genetic in addition to known risk factors (including age, gender, arterial hypertension, smoking, diabetes and dyslipidemia) strongly increases the risk of MI occurrence (3). Among the numerous genes that were previously found to be in association with MI susceptibility, 5,10-methylenetetrahydrofolate reductase (MTHFR) and factor II prothrombin (FII) genes are the most widely reported.…”
Section: Introductionmentioning
confidence: 99%