Original paper Short-term clinical outcome and dosimetric comparison of tandem and ring versus tandem and ovoids intracavitary applicators

John, Kenneth R.; Mourad, W.F.; Allbright, Robert; Packianathan, Satyaseelan; Harrell, Leslie M.; Chinchar, Edmund; Nguyen, A; Vijayakumar, Srinivasan

doi:10.5114/jcb.2015.51853

Cited by 16 publications

(8 citation statements)

References 13 publications

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“…An increase in rectum and sigmoid volume has a direct impact on increasing their hot dose points and decreasing their D 10 , D 30 , and D 50 . Increasing the D 2cm 3 and D 0.1cm 3 of these organs will result in telangiectasia, bleeding, and fistula [ 21 , 27 ]. Therefore, controlling these parameters by finding the optimum combination of these organ volumes, bladder volumes, and also tandem lengths can prevent the occurrence of such complications [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Optimum organ volume ranges for organs at risk dose in cervical cancer intracavitary brachytherapy

Siavashpour

Aghamiri

Jaberi

et al. 2016

jcb

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PurposeTo analyze the optimum organ filling point for organs at risk (OARs) dose in cervical cancer high-dose-rate (HDR) brachytherapy.Material and methodsIn a retrospective study, 32 locally advanced cervical cancer patients (97 insertions) who were treated with 3D conformal external beam radiation therapy (EBRT) and concurrent chemotherapy during 2010-2013 were included. Rotterdam HDR tandem-ovoid applicators were used and computed tomography (CT) scanning was performed after each insertion. The OARs delineation and GEC-ESTRO-based clinical target volumes (CTVs) contouring was followed by 3D forward planning. Then, dose volume histogram (DVH) parameters of organs were recorded and patients were classified based on their OARs volumes, as well as their inserted tandem length.ResultsThe absorbed dose to point A ranged between 6.5-7.5 Gy. D0.1cm3 and D2cm3 of the bladder significantly increased with the bladder volume enlargement (p value < 0.05). By increasing the bladder volume up to about 140 cm3, the rectum dose was also increased. For the cases with bladder volumes higher than 140 cm3, the rectum dose decreased. For bladder volumes lower than 75 cm3, the sigmoid dose decreased; however, for bladder volumes higher than 75 cm3, the sigmoid dose increased. The D2cm3 of the bladder and rectum were higher for longer tandems than for shorter ones, respectively. The divergence of the obtained results for different tandem lengths became wider by the extension of the bladder volume. The rectum and sigmoid volume had a direct impact on increasing their D0.1cm3 and D2cm3, as well as decreasing their D10, D30, and D50.ConclusionsThere is a relationship between the volumes of OARs and their received doses. Selecting a bladder with a volume of about 70 cm3 or less proved to be better with regards to the dose to the bladder, rectum, and sigmoid.

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Section: Discussionmentioning

confidence: 99%

Optimum organ volume ranges for organs at risk dose in cervical cancer intracavitary brachytherapy

Siavashpour

Aghamiri

Jaberi

et al. 2016

jcb

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“…T&R applicators have recently become popular in image-guided BT (IGBT) for cervical cancer due to their reproducible geometry and ease of application compared to T&O applicators [ 17 , 18 ]. Studies have shown that in dosimetric comparisons between the two applicators, T&O applicators treat larger volumes than T&R applicators [ 19 , 20 ]. In terms of rectal dose, T&R applicators with an RR achieve significantly better rectum sparing than T&O applicators with VP when the reference doses were prescribed as per the Groupe Européen de Curiethérapie-European Society for Radiotherapy & Oncology (GEC-ESTRO) guidelines [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

A comparison of dosimetric parameters in high-dose-rate intracavitary brachytherapy using tandem and ring applicators: is the combination of a rectal retractor and radio-opaque vaginal packing better than rectal retractor alone for rectum sparing in cervical cancer?

Vats¹,

Thakur²,

Sharma³

et al. 2022

ecancer

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“…However, reports showed that the rectal retractor decreased the radiation dose to the rectum more so than did vaginal packing. Therefore, TR should be used with the rectal retractor if the patient anatomy and tumor characteristics are appropriate [36, 37]. In our study, 3-D conformal and HDR brachytherapy was applied with tandem and ring applicators to all patients.…”

Section: Discussionmentioning

confidence: 99%

Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University

et al. 2019

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BackgroundRadical radiotherapy is the standard treatment for patients with locally advanced cervix uteri carcinoma (FIGO stage IB2–IVA). Worldwide, incidence and mortality rates vary among regions because of differences in lifestyles and treatment standards. Herein, we evaluated the outcomes of radical radiotherapy in patients with locally advanced cervix uteri carcinoma from the middle Black Sea region of Turkey.MethodsWe retrospectively reviewed the records of 64 consecutive patients with locally advanced cervix uteri carcinoma who were treated from January 2013 to 2016 in our radiation oncology department. All patients staging and radiotherapy planning were performed with modern imaging techniques including magnetic resonance imaging and positron-emission-tomography/computed tomography before radical radiotherapy. Thereafter, all of them were treated with external beam radiotherapy and concurrent cis-platinum-based chemotherapy followed by three-dimensional intra-cavitary high-dose-rate brachytherapy.ResultsThe median age at diagnosis was 54.5 years. The median follow-up period was 21 months. Acute grade 3 toxicity was detected in 3.1% of patients. Late toxicity was not detected in any patient. The 1- and 3-year progression-free survival rates were 83.6 and 67.5%, respectively. The 1- and 3-year overall survival rates were 95.7 and 76.9%, respectively. The most important prognostic factor was the FIGO stage. Distant metastasis was the most common cause of death in patients with locally advanced cervix uteri carcinoma despite radical radiotherapy.ConclusionsIn patients with locally-advanced cervix uteri carcinoma from the middle Black Sea region of our developing country, acceptable toxicity and survival rates are achieved similar to the recent literature from developed countries with using of modern staging, planning and radical radiotherapy techniques. However, recurrence was mostly in the form of distant metastases and further investigations on systemic therapies are required.

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Original paper Short-term clinical outcome and dosimetric comparison of tandem and ring versus tandem and ovoids intracavitary applicators

Cited by 16 publications

References 13 publications

Optimum organ volume ranges for organs at risk dose in cervical cancer intracavitary brachytherapy

Optimum organ volume ranges for organs at risk dose in cervical cancer intracavitary brachytherapy

A comparison of dosimetric parameters in high-dose-rate intracavitary brachytherapy using tandem and ring applicators: is the combination of a rectal retractor and radio-opaque vaginal packing better than rectal retractor alone for rectum sparing in cervical cancer?

Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University

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