Original Paper Inflammatory changes in biopsy specimens from patients with suspected prostate cancer

Adamczyk, Przemysław; Wolski, Zbigniew; Butkiewicz, Romuald; Nussbeutel, Joanna; Drewa, Tomasz

doi:10.5173/ceju.2013.03.art2

Cited by 7 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inflammation is very common within the prostate, as there are about 10% male adults with prostatitis ( 19 , 20 ). Several studies including a recent study found increased prostate cancer risk with a history of prostatitis and sexually transmitted diseases (relative risk = 1.30 and 1.43; 95% confidence interval: 1.10–1.54 and 1.07–1.91, respectively) ( 21 ).…”

Section: Inflammation and Prostate Cancermentioning

confidence: 99%

The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer

Lilly

Jiang

2018

Front. Immunol.

View full text Add to dashboard Cite

Toll-like receptor (TLR) 4 is expressed on normal and malignant prostate epithelial cells. The TLR4 and its downstream signaling pathways mediate innate immune responses in the host against invading pathogens. However, multiple lines of evidence shows that TLR4 expression is increased in prostate tissues from prostate cancer patients, and altered TLR4 signals may promote cancer development, as well as antitumor effects. In this review, we have summarized key features of the TLR4 signaling pathway and its associated immune responses and focused on the pathologic role of TLR4 in prostate carcinogenesis and tumor progression.

show abstract

Section: Inflammation and Prostate Cancermentioning

confidence: 99%

The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer

Lilly

Jiang

2018

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…The incidence of HG–PIN among patients subjected to biopsy due to cancer suspicion ranges from 1.5% to around 16% [6–10]. In meta–analysis of a number of studies, Epstein and Bostwick calculated the mean risk of diagnosing cancer during second biopsy in patients in whom HG–PIN was diagnosed on first biopsy to be 18.1% and 30%, respectively [11, 12, 13].…”

Section: Introductionmentioning

confidence: 99%

Significance of atypical small acinar proliferation and extensive high-grade prostatic interaepithelial neoplasm in clinical practice

Adamczyk

Wolski

Butkiewicz

et al. 2014

CEJU

Self Cite

View full text Add to dashboard Cite

IntroductionProstate cancer (PCa) is one of the most commonly diagnosed neoplasms in elderly men. The precancerous lesion of PCa is considered a high-grade prostate intraepithelial neoplasm (HG-PIN), while atypical small acinar proliferation (ASAP) is commonly considered as an under-diagnosed cancer. The aim of the study was to establish the impact of ASAP and extensive HG-PIN on pre-biopsy prostate-specific antigen (PSA) levels and the risk of cancer development in subsequent biopseis.Material and methodsThe 1,010 men suspected for PCa were included in the study based on elevated PSA, and/or positive rectal examination. Transrectal ultrasound (TRUS) guided 10 core biopsy was performed. In those with extensive HG-PIN or ASAP on the first biopsy, and/or elevated PSA value, a second biopsy was performed.ResultsIn the second biopsy, PCa was diagnosed in 6 of 19 patients (31.57%) with extensive HG-PIN, in four of 40 (10%) with BPH, and in 4 of 18 (22.22%) with ASAP.There was a statistically significant difference between the values of PSA in the group of patients with ASAP in comparison to those with benign prostate hyperplasia (BPH) (p = 0.005) as well as in patients with HG-PIN in comparison to BPH (p = 0.02).ConclusionsA precancerous lesion diagnosed upon biopsy causes a statistically significant increase in the values of PSA in relation to BPH, as well as in the case of ASAP and extensive HG-PIN.The estimate of risk of PCa diagnosis in patients with ASAP and those with extensive HG-PIN in the first biopsy is comparable, which is why there are no reasons for different treatment of patients with the above-mentioned diagnoses. Both should be subjected to urgent second biopsy in around the 4-6 weeks following the initial biopsy.

show abstract

“…In fact, a positive link between clinical history of prostatitis and increased relative risk of prostate cancer has been documented among 70,000 North American men (6). Chronic inflammation is frequently identified in prostate biopsies, radical prostatectomy specimens and tissue resected from benign prostatic hyperplasia (7,8). A number of possible etiological factors have been proposed in the development of chronic inflammation in the prostate, including dietary imbalances, exposure to environmental pollutants, alterations in testosterone:estrogen ratio, pathogen infection, race or genetic alterations (9–12).…”

Section: Introductionmentioning

confidence: 99%

Influence of chronic inflammation on Bcl-2 and PCNA expression in prostate needle biopsy specimens

et al. 2017

View full text Add to dashboard Cite

The association between inflammation and cancer has been established in certain forms of human malignancies; however, its role in prostate cancer remains unclear. The present study investigates a possible association between chronic inflammation and the development of epithelial neoplasia in the prostate. Needle biopsy specimens were obtained from patients with serum prostate-specific antigen levels >4 ng/ml, evaluated for morphological findings, and immunostained for Bcl-2 and proliferating cell nuclear antigen (PCNA). Bcl-2 is a survival protein that appears to lie at a nodal point in pathways involved in cell survival, carcinogenesis, and development of therapeutic resistance in certain cancer types. Similarly, PCNA is a critical protein for DNA replication, repair of DNA damage, chromatin structure maintenance, chromosome segregation and cell-cycle progression. The association between these two proteins was examined in prostate tissues with and without chronic inflammation, as well as tissues with and without evidence of neoplastic changes. Of the 106 needle biopsies examined, 18% exhibited atrophy with inflammation. Proliferative inflammatory atrophy/post-atrophic hyperplasia were observed in 42%, high-grade prostatic intraepithelial neoplasia (HGPIN) in 8%, prostatic adenocarcinoma in 11%, and 2% had atypical acinar proliferation suspicious for malignancy. A total of 36 specimens were stained for Bcl-2 and PCNA. Bcl-2 was expressed widely in inflammatory and epithelial tissue; however, more intense expression was observed in the areas of chronic inflammation, predominantly in infiltrating immune cells. The highest proliferation index was observed in the epithelia of HGPIN and cancer. An inverse correlation between the expression of Bcl-2 and the expression of PCNA was observed in the epithelium. The areas of chronic inflammation were associated with increased Bcl-2 expression, whereas the highly proliferative epithelium minimally expressed Bcl-2. These results suggest that Bcl-2 alters the phenotype of particular epithelial cells with a gain in neoplastic characteristics, leading to a likely precursor that may later progress into HGPIN and cancer.

show abstract

Original Paper Inflammatory changes in biopsy specimens from patients with suspected prostate cancer

Cited by 7 publications

References 28 publications

The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer

The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer

Significance of atypical small acinar proliferation and extensive high-grade prostatic interaepithelial neoplasm in clinical practice

Influence of chronic inflammation on Bcl-2 and PCNA expression in prostate needle biopsy specimens

Contact Info

Product

Resources

About