Original Contribution: Top 10 botanical ingredients in 2010 anti‐aging creams

Cronin, Hyland; Draelos, Zoe Diana

doi:10.1111/j.1473-2165.2010.00516.x

Cited by 54 publications

(42 citation statements)

References 88 publications

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“…Several cosmetics companies formulated kinetin in preparations of skin care products and described the plant hormone CK as antiaging agent [32], without further indications to the specific mechanism. According to our results and those of others, its antioxidative capacity may provide a mechanistic basis for such an activity.…”

Section: Resultsmentioning

confidence: 99%

The Plant Hormone Cytokinin Confers Protection against Oxidative Stress in Mammalian Cells

et al. 2016

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Modulating key dynamics of plant growth and development, the effects of the plant hormone cytokinin on animal cells gained much attention recently. Most previous studies on cytokinin effects on mammalian cells have been conducted with elevated cytokinin concentration (in the μM range). However, to examine physiologically relevant dose effects of cytokinins on animal cells, we systematically analyzed the impact of kinetin in cultured cells at low and high concentrations (1nM-10μM) and examined cytotoxic and genotoxic conditions. We furthermore measured the intrinsic antioxidant activity of kinetin in a cell-free system using the Ferric Reducing Antioxidant Power assay and in cells using the dihydroethidium staining method. Monitoring viability, we looked at kinetin effects in mammalian cells such as HL60 cells, HaCaT human keratinocyte cells, NRK rat epithelial kidney cells and human peripheral lymphocytes. Kinetin manifests no antioxidant activity in the cell free system and high doses of kinetin (500 nM and higher) reduce cell viability and mediate DNA damage in vitro. In contrast, low doses (concentrations up to 100 nM) of kinetin confer protection in cells against oxidative stress. Moreover, our results show that pretreatment of the cells with kinetin significantly reduces 4-nitroquinoline 1-oxide mediated reactive oxygen species production. Also, pretreatment with kinetin retains cellular GSH levels when they are also treated with the GSH-depleting agent patulin. Our results explicitly show that low kinetin doses reduce apoptosis and protect cells from oxidative stress mediated cell death. Future studies on the interaction between cytokinins and human cellular pathway targets will be intriguing.

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Section: Resultsmentioning

confidence: 99%

The Plant Hormone Cytokinin Confers Protection against Oxidative Stress in Mammalian Cells

et al. 2016

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“…RosmarinusOfficinalis (Rosemary/ Biberiye) Topikal:Eritem, deri tümörü gelişiminin engellenmesi 30,49 Hamilelik ve emzirme döneminde güvenliği kanıtlanmamıştır. Yeterli veri yokluğu nedeniyle kullanılması tavsiye edilmez.…”

Section: Tablo1devamıunclassified

Gebelik ve emzirme döneminde kozmesötik kullanımı

Yıldız¹,

Abuaf²

2013

TURKDERM

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“…Ergo is mainly found in mushrooms [1819], while diosgenin in wild yam [20]. Both of them have been listed in the top 10 botanical ingredients present on anti-aging creams in 2010 owing to their strong antioxidant activity [21], suggesting that GEB may be used as a functional cosmetic agent as well as in medicinal food.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of Gastrodia elata Blume extract on alpha-melanocyte stimulating hormone-induced melanogenesis in murine B16F10 melanoma

Shim

Song

Choi³

et al. 2017

Nutr Res Pract

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BACKGROUND/OBJECTIVESGastrodia elata Blume (GEB), a traditional herbal medicine, has been used to treat a wide range of neurological disorders (e.g., paralysis and stroke) and skin problems (e.g., atopic dermatitis and eczema) in oriental medicine. This study was designed to investigate whether GEB extract inhibits melanogenesis activity in murine B16F10 melanoma.MATERIALS/METHODMurine B16F10 cells were treated with 0-5 mg/mL of GEB extract or 400 µg/mL arbutin (a positive control) for 72 h after treatment with/without 200 nM alpha-melanocyte stimulating hormone (α-MSH) for 24 h. Melanin concentration, tyrosinase activity, mRNA levels, and protein expression of microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein (Trp)1, and Trp2 were analyzed in α-MSH-untreated and α-MSH-treated B16F10 cells.RESULTSTreatment with 200 nM α-MSH induced almost 2-fold melanin synthesis and tyrosinase activity along with increased mRNA levels and protein expression of MITF, tyrosinase, Trp1 and Trp2. Irrespective of α-MSH stimulation, GEB extract at doses of 0.5-5 mg/mL inhibited all these markers for skin whitening in a dose-dependent manner. While lower doses (0.5-1 mg/mL) of GEB extract generally had a tendency to decrease melanogenesis, tyrosinase activity, and mRNA levels and protein expression of MITF, tyrosinase, Trp1, and Trp2, higher doses (2-5 mg/mL) significantly inhibited all these markers in α-MSH-treated B16F10 cells in a dose-dependent manner. These inhibitory effects of the GEB extract at higher concentrations were similar to those of 400 µg/mL arbutin, a well-known depigmenting agent.CONCLUSIONSThese results suggest that GEB displays dose-dependent inhibition of melanin synthesis through the suppression of tyrosinase activity as well as molecular levels of MITF, tyrosinase, Trp1, and Trp2 in murine B16F10 melanoma. Therefore, GEB may be an effective and natural skin-whitening agent for application in the cosmetic industry.

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Original Contribution: Top 10 botanical ingredients in 2010 anti‐aging creams

Cited by 54 publications

References 88 publications

The Plant Hormone Cytokinin Confers Protection against Oxidative Stress in Mammalian Cells

The Plant Hormone Cytokinin Confers Protection against Oxidative Stress in Mammalian Cells

Gebelik ve emzirme döneminde kozmesötik kullanımı

Inhibitory effect of Gastrodia elata Blume extract on alpha-melanocyte stimulating hormone-induced melanogenesis in murine B16F10 melanoma

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