Original Articles: Bladder Cancer: The Risk of Urethral Tumors in Female Bladder Cancer: Can the Urethra be Used for Orthotopic Reconstruction of the Lower Urinary Tract?

Stenzl, Arnulf; Draxl, Hermann; Posch, Bernd; Colleselli, K.; Falk, Markus; Bartsch, Georg

doi:10.1016/s0022-5347(01)67611-0

Cited by 127 publications

(40 citation statements)

References 16 publications

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“…The incidence of second primary tumors in females subjected to orthotopic neobladder substitution is comparable to male series and predictive (22)(23)(24). In 841 female patients followed for more than 20 years, the urethral tumor rate was 2%.…”

Section: Orthotopic Urinary Diversion and Tumor Recurrencementioning

confidence: 67%

Radical cystectomy with orthotopic neobladder for invasive bladder cancer: a critical analysis of long-term oncological, functional, and quality of life results

Nagele¹,

Anastasiadis²,

Stenzl

et al. 2011

World J Urol

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Purpose: Analyze current knowledge and practice regarding tumor-related cystectomy with subsequent orthotopic neobladder both in male and female patients. Design, setting, and participants: Evaluate literature predominantly from the last decade dealing with long-term experience in large numbers of patients with an orthotopic neobladder following cystectomy. Oncological outcome specific to an orthotopic neobladder, functional aspects such as urinary continence, renal function, sexual activity and other quality of life issues are elucidated. Results: Local pelvic recurrences after urothelial bladder cancer occur in 7-12%. Urethral second primary tumors in male and female patients in contemporary series with bladder substitution are 4-6% and 1.4 o 4%, respectively. Upper tract recurrences vary between 2.4-17%. Complications regarding the upper urinary tract have dramatically diminished due to simplified forms of upper tract protection as well as a more refined technique of ureterointestinal anastomosis. Depending on the technique ureteroileal stenosis was lately reported to lie between 2.7 to 3.8%. Renal function remained stable in 96% after a mean follow-up of up to 5 years. Conclusion: Radical cystectomy in carefully selected patients has stood the test of time by providing adequate long-term survival and low local recurrence rates. Orthotopic bladder substitution does not compromise oncological outcome, yields excellent functional results, is cost effective compared to other types of urinary diversion, may improve quality of life and should therefore be the diversion of choice both in men and women. Chronological age is generally not a contraindication for cystectomy, but for orthotopic urinary diversion, tumor extent, functional pelvic floor deficits and general life expectancy are limiting factors.

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Section: Orthotopic Urinary Diversion and Tumor Recurrencementioning

confidence: 67%

Radical cystectomy with orthotopic neobladder for invasive bladder cancer: a critical analysis of long-term oncological, functional, and quality of life results

Nagele¹,

Anastasiadis²,

Stenzl

et al. 2011

World J Urol

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“…Urethral preservation under specific criteria of tumor site and extension is quite safe and facilitates orthotopic reconstruction with spontaneous voiding and improves the quality of life in such patients [16,17]. Pathological studies in female radical cystectomy specimens have demonstrated that the urethra is rarely involved in the absence of bladder-neck involvement [18] or extensive carcinoma in situ [19].…”

Section: Rational and Value Of Urethral Preservation In Genital-sparimentioning

confidence: 99%

Genital Organs-Sparing Radical Cystectomy in Female Patients with Muscle Invasive Urothelial Carcinoma of the Bladder

Salem¹

2017

Bladder Cancer - Management of NMI and Muscle-Invasive Cancer

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There has been considerable interest in urethral-sparing cystectomy and preservation of the gynecological tract to maintain continence mechanism, sexual function, and reproductive function in young patients who undergo radical cystectomy for muscle-invasive bladder cancer and this new technique gained acceptance in many centers. The issue of oncological safety of a urethra and anterior vaginal wall-sparing cystectomy in selected patients has been addressed by several authors. The chapter will discuss the following items: (

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“…They concluded that the only consistent risk factor is bladder neck involvement. 19 Indeed, the most widely accepted risk factor in the literature for urethral involvement in women is tumour at the bladder neck. However, it should be pointed out that while gross tumour in the urethra mandates an en bloc urethrectomy, there is no consensus on the management of the urethra when the bladder neck is involved.…”

Section: Female Risk Factorsmentioning

confidence: 99%

“…10 In this group, superficial urethral disease did not carry a better prognosis than invasive urethral disease; however, reports on the relative impact of urethral and bladder pathology on diseasespecific survival are contradictory. 1,14,19,25 …”

Section: Management Of Recurrence and Survivalmentioning

confidence: 99%

Management of the urethra in urothelial bladder cancer

Kanaroglou

Shayegan

2013

CUAJ

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The standard of care in the management of invasive urothelial cancer of the bladder is radical cystectomy and pelvic lymphadenectomy. Although uncommon, recurrence of disease in the retained urethra following cystectomy carries a poor prognosis. The need for assessment of risk of recurrence is greater now than ever with wider adoption of orthotopic bladder substitution. This review will address the contemporary management of the urethra following cystectomy for urothelial cancer.

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Original Articles: Bladder Cancer: The Risk of Urethral Tumors in Female Bladder Cancer: Can the Urethra be Used for Orthotopic Reconstruction of the Lower Urinary Tract?

Cited by 127 publications

References 16 publications

Radical cystectomy with orthotopic neobladder for invasive bladder cancer: a critical analysis of long-term oncological, functional, and quality of life results

Radical cystectomy with orthotopic neobladder for invasive bladder cancer: a critical analysis of long-term oncological, functional, and quality of life results

Genital Organs-Sparing Radical Cystectomy in Female Patients with Muscle Invasive Urothelial Carcinoma of the Bladder

Management of the urethra in urothelial bladder cancer

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