ORIGINAL ARTICLE: Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial

Akhondzadeh, Shahin; Sabet, Mohammad; Harirchian, Mohammad-Hossein; Togha, Mansoureh; Cheraghmakani, Hamed; Razeghi, Soodeh; Hejazi, Seyyed Amir; Yousefi, Mohammad Hosein; Alimardani, Roozbeh; Jamshidi, A H; Zare, Fateme; Moradi, Ali Mashinchian

doi:10.1111/j.1365-2710.2009.01133.x

Cited by 202 publications

(140 citation statements)

References 33 publications

(66 reference statements)

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“…Τhe antioxidant properties of extract of C. sativus stigmas and its effect on Aβ1-40 fibrillogenesis were evaluated in double-blind, placebo-controlled study in 46 patients with Alzheimer's disease. [54] Patients group that received 15 mg of saffron extract twice daily for 16 weeks had better outcome on cognitive functions than the placebo group. In a second study of the same research group, [33] the same saffron extract dose was administered to 54 adults with mild to moderate Alzheimer's disease, age older than 55 years, in comparison with standard administration of 10 mg/day of donepezil, for 22 weeks.…”

Section: Eirini Christodoulou Et Almentioning

confidence: 88%

“…Alzheimer's disease Clinical study: 16-week, double-blind study, randomized, placebocontrolled study. [54] 40 patients with mild to moderate Alzheimer's disease randomized to receive: capsule saffron (15 mg twice per day) or (two capsules placebo per day).…”

Section: Anxiety and Insomniamentioning

confidence: 99%

“…[73] Furthermore, saffron extract and its components have been tested in Alzheimer's and Parkinson's disease. [33,54,55] Alzheimer's disease is characterized pathologically by deposition of amyloid β-peptide (Aβ) fibrils. Oxidation is thought to promote Aβ fibril formation and deposition.…”

Section: Eirini Christodoulou Et Almentioning

confidence: 99%

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Saffron: a natural product with potential pharmaceutical applications

Christodoulou

Kadoglou

Kostomitsopoulos

et al. 2015

Journal of Pharmacy and Pharmacology

174

101

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Objectives Recently, a great deal of interest has been developed to isolate and investigate novel bioactive components from natural resources with health beneficial effects. Saffron is the dried stigma of Crocus sativus L. and has been used for centuries in traditional medicine mainly for its healing properties, as well as for the treatment of various pathological conditions. Objectives of the present review are to unravel its therapeutic properties and investigate the potential applications of saffron in contemporary therapy of a wide spectrum of diseases and summarize previous and current evidence regarding the biological/pharmacological activities of saffron and its active ingredients and their possible therapeutic uses. Key findings Recent phytochemistry and pharmacological experiments have indicated that crocin and safranal, the major active ingredients of saffron, exert important actions, such as antioxidant, anti-tumor, anti-diabetic, anti-inflammatory and anti-atherosclerotic. Unfortunately, the vast majority of those data derive from in vitro studies, whereas a limited number of in vivo experiments support the aforementioned effects. In addition to studies with mechanistic implications, very few clinical trials provide preliminary evidence of saffron potentiality to alleviate depression and increase cognitive function in patients with Alzheimer's disease. Summary The history and structural features of saffron constituents are given in the first part of the review, followed by a comprehensive and critical presentation of the published preclinical and clinical studies and review papers on the pharmacology and possible therapeutic uses of saffron and its main active components crocin and safranal.

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Section: Eirini Christodoulou Et Almentioning

confidence: 88%

Section: Anxiety and Insomniamentioning

confidence: 99%

See 1 more Smart Citation

Saffron: a natural product with potential pharmaceutical applications

Christodoulou

Kadoglou

Kostomitsopoulos

et al. 2015

Journal of Pharmacy and Pharmacology

174

101

View full text Add to dashboard Cite

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“…Akhondzadeh et al in a double-blind, placebocontrolled study suggests that at least in the short-term, saffron (30 mg/day for 16 weeks) is both safe and effective in mild to moderate Alzheimer's disease [14].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial

Basirimoghadam

Hamzei

Moslem

et al. 2016

Zahedan J Res Med Sci

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Background: Anxiety is an unpleasant state of feeling agitation and pressure induced by the patient's fear of hospitalization, anesthesia or surgery. Objectives: The present study is aimed to compare the effects of dried extract of saffron and diazepam on soothing the preherniorrhaphy surgery anxiety. Patients and Methods:In this double blind clinical study, during 8 months, 102 patients were studied in 2012. all the patients in intervention group (n = 50) received 25 mg dried extract of saffron and participants in control group (n = 52) received 5 mg oral diazepam. Level of anxiety of the patients was measured using speillberger state-trait anxiety inventory (STAI) before intervention and 3 hours after administration (immediately after entering the surgery room) filled out by the patients. The patients in the two groups were compared concerning level of anxiety before/after intervention. The two groups of participants had almost equal demographic features.

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“…Crocetin has been reported to inhibit Aβ fibrillization and stabilize Aβ oligomers [13]. We recently reported that crocetin prevents retinal damage induced by H 2 O 2 , tunicamycin, and N-methyl-Daspartate (NMDA) [14,15]; saffron extracts have been reported to be effective on memory deficit on mild AD patient [16,17]. However, there was no report on protective effects of crocetin in hippocampal neuronal cells having been examined.…”

Section: Introductionmentioning

confidence: 96%

Crocetin Prevents Amyloid <i>β</i><sub>1-42</sub>-Induced Cell Death in Murine Hippocampal Cells

Yoshino¹,

Ishisaka²,

Umigai³

et al. 2014

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Crocetin is an aglycon of carotenoid extracted by saffron stigmas (Crocus sativus L.) and known to have a potent anti-oxidative effect. Amyliod β (Aβ), hallmark of Alzheimer's disease, is reported to have neurotoxicity partly via oxidative stress. In this study, we investigated the effect of crocetin on hippocampal HT22 cell death induced by Aβ 1-42 . Furthermore, to clarify the mechanism underlying the protective effects of crocetin against Aβ 1-42 -induced cell death, we measured reactive oxygen species (ROS) production by CM-H 2 DCFDA kit assay. Crocetin at 1 -10 μM protected HT22 cells against Aβ 1-42 -induced neuronal cell death and decreased ROS production increased by Aβ 1-42 . These results that crocetin has the potent neuroprotective effect against Aβ 1-42 -induced cytotoxicity in hippocampal cells by attenuating oxidative stress, suggest that crocetin may provide a useful therapeutic strategy against Aβ-related disorders.

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ORIGINAL ARTICLE: Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial

Abstract: This double-blind, placebo-controlled study suggests that at least in the short-term, saffron is both safe and effective in mild to moderate AD. Larger confirmatory randomized controlled trials are called for.

Cited by 202 publications

References 33 publications

Saffron: a natural product with potential pharmaceutical applications

Saffron: a natural product with potential pharmaceutical applications

Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial

Crocetin Prevents Amyloid <i>β</i><sub>1-42</sub>-Induced Cell Death in Murine Hippocampal Cells

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ORIGINAL ARTICLE: Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial

Abstract: This double-blind, placebo-controlled study suggests that at least in the short-term, saffron is both safe and effective in mild to moderate AD. Larger confirmatory randomized controlled trials are called for.

Cited by 202 publications

References 33 publications

Saffron: a natural product with potential pharmaceutical applications

Saffron: a natural product with potential pharmaceutical applications

Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial

Crocetin Prevents Amyloid &lt;i&gt;β&lt;/i&gt;&lt;sub&gt;1-42&lt;/sub&gt;-Induced Cell Death in Murine Hippocampal Cells

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Product

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Crocetin Prevents Amyloid <i>β</i><sub>1-42</sub>-Induced Cell Death in Murine Hippocampal Cells