Original article: Rhinoconjunctivitis in 5‐year‐old children: a population‐based birth cohort study

Marinho, Susana; Simpson, Angela; Lowe, Lesley; Kissen, Patricia; Murray, Clare; Čustović, Adnan

doi:10.1111/j.1398-9995.2006.01294.x

Cited by 86 publications

(101 citation statements)

References 35 publications

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“…The presence of sensitization is a major risk factor for AR in children (19,51). Outdoor allergens constitute a risk of seasonal rhinitis, whereas indoor allergens are associated with perennial rhinitis (52). The information on absence of sensitization can be clinically very valuable potentially ruling out a diagnosis of AR.…”

Section: Defining the Presence Of Allergymentioning

confidence: 99%

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Roberts

Xatzipsalti

Borrego

et al. 2013

Allergy

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270

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Rhinitis is a common problem in childhood and adolescence and impacts negatively on physical, social and psychological well-being. This position paper, prepared by the European Academy of Allergy and Clinical Immunology Taskforce on Rhinitis in Children, aims to provide evidence-based recommendations for the diagnosis and therapy of paediatric rhinitis. Rhinitis is characterized by at least two nasal symptoms: rhinorrhoea, blockage, sneezing or itching.

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Section: Defining the Presence Of Allergymentioning

confidence: 99%

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Roberts

Xatzipsalti

Borrego

et al. 2013

Allergy

Self Cite

270

248

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“…Long-term studies on children are appropriately carried out with birth cohorts. It has already been observed in some cohorts that many children with nasal symptoms are not allergic (35,36). GA 2 LEN has made a special effort to coordinate a large number of European birth cohorts (41,42).…”

Section: Epidemiologic Studiesmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

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163

148

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA 2 LEN paper Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.

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“…Some interesting results concerning the characteristic of respiratory allergy emerged from our study. First, there was a very low rate of positive family history compared to the general population [7, 15], even in the same area [16]. This would indirectly suggest that a genetic background is not mandatory to develop allergy.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Characteristics of Respiratory Allergy in Immigrants in Northern Italy

Lombardi

Penagos

Senna

et al. 2008

Int Arch Allergy Immunol

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Background: Respiratory allergy is influenced and determined by genetic and environmental factors. Migration is a good epidemiological model to indirectly assess the influence of the environment. We assessed the clinical characteristics of respiratory allergy in immigrants in Brescia, Italy. Methods: We prospectively collected the data of all immigrants referred to our allergy service for respiratory complaints since 1992. All patients underwent a standard diagnostic workup. The records of a matched Italian population of 1,534 patients were examined for comparison. Results: Two hundred and thirty-seven patients were evaluated (108 male, mean age 36.3 years). Their countries of origin were uniformly distributed among 4 macroareas (Asia, Africa, South America, Eastern Europe). All patients were referred less than 1 month after the onset of symptoms. Family history for atopy was positive in 9% and clinical history of respiratory allergy was positive in 2%. The mean time of onset of symptoms after immigration was 5.21 years, and the onset symptoms were rhinitis and asthma in 68% patients. Twenty-five percent were monosensitized subjects and 20% of patients had cockroach positivity. Some characteristics (family history, previous clinical history and severity of rhinitis) were clearly different from those of the Italian control population. Conclusion: In this population of immigrants, it seems that environmental factors, more than genetic ones, play a role in the onset of respiratory allergy.

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Original article: Rhinoconjunctivitis in 5‐year‐old children: a population‐based birth cohort study

Cited by 86 publications

References 35 publications

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

The Clinical Characteristics of Respiratory Allergy in Immigrants in Northern Italy

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Original article: Rhinoconjunctivitis in 5‐year‐old children: a population‐based birth cohort study

Cited by 86 publications

References 35 publications

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

The Clinical Characteristics of Respiratory Allergy in Immigrants in Northern Italy

Contact Info

Product

Resources

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper