ORIGINAL ARTICLE: Repertoire and Clonality of T‐Cell Receptor Beta Variable Genes Expressed in Endometrium and Blood T Cells of Patients with Recurrent Spontaneous Abortion

Abstract

Endometrial T cells have a skewed TCRBV repertoire with restricted transcript heterogeneity, which is shared by both groups and minor variations observed in this pattern in RSA patients may reflect more recent and/or repeated exposure to nominal antigens or superantigens.

Changes and clinical significance of peripheral blood helper T lymphocyte and natural killer (NK) cells in unexplained recurrent spontaneous abortion (URSA) patients after abortion and successful pregnancy

“…The conditions of URSA: 1) continuous spontaneous abortions twice or more than twice; 2) chromosome karyotype of the couple were normal; 3) the determination of reproductive hormone was normal, with no endocrine disease history; 4) without the infections of chlamydia trachomatis and mycoplasma urealytium; 5) without organic disease in genital tract; 6) autoimmune antibody was negative; 7) the examination of semen was normal [9].…”

Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal–Maternal Interface and the Peripheral Blood

“…For instance, large differences in T cell repertoire profile have been observed between peripheral blood mononuclear cells (PBMC) and colon tissue (2), with colon-resident T cells expressing a much more restricted TRBV signature (3). Compartment-specific T cell repertoires have also been noted at the fetal–maternal interface (4). This site is anatomically known as the decidua and only global TRBV usage in decidual mononuclear cells (DMC) have been examined to date.…”

Enfoque actual del aborto recurrente

“…El balance entre la inmunidad celular (Th1) representada por los linfocitos T y sus citoquinas IL-2, TNF-α e IFN-γ y la humoral (Th2), efectuada por los linfocitos B y las citoquinas IL-4, IL-5, IL-10, parece tener un papel importante en el mantenimiento de la gestación, desde el punto de vista inmunológico, y podría estar en parte regulada por la progesterona (49)(50)(51) . Otro estudio encontró que las células T endometriales tienen un repertorio del gen del receptor de la célula T beta variable (TCRBV) alterado, en casos de aborto recurrente, con restricción de la heterogeneidad de transcripción, lo que se atribuye a una posible exposición reciente o repetida a antígenos nominales o superantígenos (52) . También se ha encontrado activación inmunológica de los linfocitos T y las células asesinas naturales (NK), con alteración del balance de receptores inhibitorios y activadores (KIRs) en las células NK uterinas durante la fase media lútea de pacientes con aborto espontáneo recurrente inexplicado (48,53,54) .…”