ORIGINAL ARTICLE: Lack of Consistent Association Between Endothelial Nitric Oxide Synthase Gene Polymorphisms, Homocysteine Levels and Recurrent Pregnancy Loss in Tunisian Women

Zammiti, Walid; Mtiraoui, Nabil; Mahjoub, Touhami

doi:10.1111/j.1600-0897.2007.00551.x

Cited by 35 publications

(33 citation statements)

References 38 publications

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“…Previous studies have demonstrated a lack of consistent association between the rs2070744 polymorphism and recurrent pregnancy loss in Tunisians (Zammiti et al, 2008) and Koreans (Shin et al, 2010). The current study suggests that this polymorphism was unassociated with the development of RSA in a Chinese population sample.…”

Section: Discussionmentioning

confidence: 56%

Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage

Luo¹,

Li²,

Shan³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Endothelial nitric oxide synthase (eNOS) is an enzyme that influences placental human chorionic gonadotropin production during gestation. Previous studies have indicated an association between eNOS activity, implantation, and maintenance of pregnancy, but proposed associations between polymorphisms of the eNOS gene and recurrent miscarriage (RM) are controversial. To identify markers contributing to the genetic susceptibility to RM, we examined the potential association between RM and 8 single nucleotide polymorphisms (SNPs; rs1799983, rs2070744, rs11771443, rs3918188, rs2853796, rs7830, rs1541861, and rs2853792) of the eNOS gene using the MassARRAY system (Sequenom, USA). The enrolled participants included 192 RM patients and 201 women with normal fertility as controls. The results showed that rs1799983 at exon 7 of the eNOS gene was significantly associated with RM (genotype: chi-square = 15.071, P = 0.001; allele: chi-square = 6.250, P = 0.016). Another significant association was observed for rs11771443 in the promoter (genotype: chi-square = 6.259, P = 0.044; allele: chi-square = 7.076, P = 0.008). Furthermore, strong linkage disequilibrium was observed in 3 blocks (Dꞌ > 0.9), and significantly fewer T-T-G haplotypes (chi-square = 5.981, P = 0.015) residing in block 1 were found in RM patients. These findings point to a role for eNOS gene polymorphisms in RM in the Chinese Han population and may be informative for future genetic or neurobiological studies of RM.

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Section: Discussionmentioning

confidence: 56%

Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage

Luo¹,

Li²,

Shan³

et al. 2013

Genet. Mol. Res.

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“…It has been shown that nitric oxide release by endothelial cells is reduced by high Hcy levels. Reduction in nitric oxide leads to platelet adhesion and aggregation, thus promoting thrombosis and vascular diseases (Erol et al, 2007); this may affect blood supply to the placenta and the fetus (Zammiti et al, 2008). In addition to the vascular endothelial cells, Hcy can also affect the structure and function of blood vessels by regulating smooth muscle cell proliferation (Zou et al, 2010) and migration (Jiang et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Blood folic acid, vitamin B12, and homocysteine levels in pregnant women with fetal growth restriction

2016

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ABSTRACT. Deficiencies in nutrients such as folic acid and vitamin B12 may play a role in fetal growth restriction (FGR). However, whether folic acid, vitamin B12, or homocysteine is associated with FGR in Chinese populations remains unclear. This study investigated the relationship between these nutrient deficiencies and FGR in pregnant Chinese women. We selected 116 mother and infant pairs, and categorized the neonates into the FGR, appropriate for gestational age, and large for gestational age groups. Birth weight, body length, head circumference, body mass index (BMI), and Rohrer's body index of the newborns were measured. Serum folic acid, vitamin B12, and homocysteine levels were measured in mothers during the first three days of their hospital stay. Results showed that the FGR group exhibited reduced folic acid and vitamin B12 levels and elevated homocysteine levels than those in the other two groups. Folic acid and vitamin B12 levels were positively correlated with birth weight, head circumference, and BMI, whereas homocysteine level was negatively correlated with these variables. The FGR ratio in the folic acid and vitamin B12 deficiency group was higher than that in the sufficiency group (χ 2 = 4.717 and 4.437, P = 0.029 and 0.035, respectively). In addition, elevated homocysteine was associated with FGR (χ 2 = 5.366, P = 0.021). In conclusion, we found that folic acid and vitamin B12 deficiency was associated with elevated homocysteine levels, which may increase susceptibility to FGR.

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“…The association between eNOS gene polymorphisms and recurrent early pregnancy losses has been studied among various ethnic groups, including Caucasian, South Indian, Chinese, Greek, and Tunisian (Tempfer et al, 2001;Suryanarayana et al, 2006;Fan et al, 2007;Karvela et al, 2008;Zammiti et al, 2008). The results of the various studies conflicted with each other.…”

Section: Discussionmentioning

confidence: 92%

Endothelial Nitric Oxide Synthase (eNOS) gene polymorphisms in spontaneously aborted embryos

et al. 2010

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Endothelium-derived nitric oxide (NO) is synthesized from L-arginine by endothelial nitric oxide synthase (eNOS) encoded by the eNOS gene on chromosome 7. The effects of the eNOS polymorphisms with the risk of spontaneous pregnancy losses are conflicting. In this study, we investigated the association of the eNOS genotypes with spontaneously aborted embryos in Koreans. Case-control studies were performed to evaluate the association between endothelial nitric oxide synthase (eNOS) gene polymorphisms and spontaneously aborted embryos. Ninety-nine spontaneously aborted fetuses at <20 weeks of gestational age and 103 child controls and 282 adult controls. Genotype frequency of three eNOS gene polymorphisms, -786T>C, VNTR in intron 4 (4a4b), and 894G>T in spontaneously aborted embryos was surveyed. The frequencies of -786TC and CC genotypes in aborted embryos were significantly higher than in both child and adult controls. The frequencies of 4a4a homozygote of VNTR polymorphism in intron 4 and TT homozygote of 894G>T polymorphisms were also higher in aborted embryos than in adult controls. Haploptype analysis suggested that -786T>C polymorphism was a possible risk factor for spontaneously aborted embryos. eNOS gene polymorphisms, -786T>C, VNTR in intron 4 (4a4b), and 894G>T, are associated with the risk of spontaneously aborted fetuses.

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ORIGINAL ARTICLE: Lack of Consistent Association Between Endothelial Nitric Oxide Synthase Gene Polymorphisms, Homocysteine Levels and Recurrent Pregnancy Loss in Tunisian Women

Abstract: The present study identified a lack of association between eNOS gene polymorphisms, the risk of RPL and tHcy levels.

Cited by 35 publications

References 38 publications

Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage

Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage

Blood folic acid, vitamin B12, and homocysteine levels in pregnant women with fetal growth restriction

Endothelial Nitric Oxide Synthase (eNOS) gene polymorphisms in spontaneously aborted embryos

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