ORIGINAL ARTICLE: Immune Regulation at the Interface During Early Steps of Murine Implantation: Involvement of Two New Cytokines of the IL‐12 Family (IL‐23 and IL‐27) and of TWEAK

Abstract

TWEAK is likely offering protection against the deleterious effects of TNF in implantation explaining embryo survival in a TNF-rich environment, and equal number of implants in both strains. However, there is a clear difference of protection in abortion-prone mating peaking in the abortion/resorption window but starting early, and therefore possible links with the prevention of abortion in CBA x DBA/2 matings by interfering with complement activation as recently described by Girardi et al. are discussed, as well as consequences for our current view of feto-maternal 'seed and soil' interplay. The apparently paradoxical effects of IL-27 neutralization are also discussed.

Interleukin-27 and interleukin-12 augment activation of distinct cord blood natural killer cells responses via STAT3 pathways

“…It is known that IL-27 is elevated in the placenta and maternal serum during normal pregnancy. 26,27 We also investigated whether IL-27 receptors (gp130 and WSX-1) were detectable in umbilical cord blood NK cells, especially after stimulation with IL-27 and IL-12. Our results indicated that gp130 protein may be inducible, and that IL-27 takes a period of time (24e48 hours) for induction of its activation (Fig.…”

Identification and expression analysis of two interleukin-23α (p19) isoforms, in rainbow trout Oncorhynchus mykiss and Atlantic salmon Salmo salar

“…One peculiar observation was the high expression of the salmon p19 paralogues and trout p19a in gonad, perhaps suggesting that an IL-23 isoform may have a role in the salmonid reproductive system. p19 is known to be expressed in the reproductive tract in mammals (Mas et al, 2008).…”

Mechanisms of maternal tolerance to the fetus: lessons of molecular diplomacy

“…TWEAK экспрессирован в плаценте человека и мы-шей, и его содержание снижалось в мышиной моде-ли спонтанного аборта, а нейтрализация этого фак-тора in vivo приводила к усиленной резорбции пло-дов [75].…”