“…During pregnancy, ATX concentration is upregulated in the serum and placenta of healthy women in the third trimester. Interestingly, patients with pregnancyinduced hypertension (preeclampsia) harbored decreased ATX levels in the third trimester compared with healthy women (56,167,168). LPA receptors are also expressed in the testis (19,77,88), suggesting a role for LPA signaling in male sperm behavior and fertility.…”