ORIGINAL ARTICLE: Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells

Laškarin, Gordana; Redžović, Arnela; Rubeša, Željka; Mantovani, Alberto; Allavena, Paola; Haller, Herman; Vlastelić, Ivan; Rukavina, Daniel

doi:10.1111/j.1600-0897.2008.00599.x

Cited by 42 publications

(44 citation statements)

References 28 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that self-reactive T cell clones can be restricted by either of CD1a and CD1d molecules [40]. In addition, tight regulation of NK cell function by CD1a+ DCs in the human deciduas may affect successful implantation of the embryos [43]. Interestingly, there are existing evidence on the cross regulation of CD1a expression on iDCs by CD1d-dependent iNKT cell responses [44].…”

Section: Discussionmentioning

confidence: 97%

CD1a and CD1d Genes Polymorphisms in Breast, Colorectal and Lung Cancers

Golmoghaddam

Pezeshki

Ghaderi

et al. 2011

Pathol. Oncol. Res.

View full text Add to dashboard Cite

CD1 molecules might contribute to anti-tumor immune response by presentation of tumor-derived lipid and glycolipid antigens to T cells and NKT cells. Polymorphisms in CD1 genes have been suggested to modify ligand binding of CD1 molecules and thereby change the antigen presenting ability of these molecules. The aim of this study was to investigate the exon 2 polymorphisms of CD1a and CD1d in several high incident cancers in Iran. For this purpose, 201 female breast cancer patients and 207 healthy women, 64 lung cancer patients and 95 healthy individuals and 109 patients with colorectal cancer and 109 healthy controls were recruited to this study. Using PCR-SSP method, no significant correlation was found in genotype and allele frequencies of CD1a between all three studied groups and their control counterparts. Moreover, a dominant frequency of CD1d 01 (A) allele was observed in the majority of studied individuals. No significant association between the CD1 polymorphisms and prognostic factors in breast, lung and colorectal cancers was detected. Our results highlight the conserved nature of CD1 genes and may point to the immuoregulatory functions of CD1 molecules in cancer that can be exerted through fine tuning of NK, T and NKT cells.

show abstract

Section: Discussionmentioning

confidence: 97%

CD1a and CD1d Genes Polymorphisms in Breast, Colorectal and Lung Cancers

Golmoghaddam

Pezeshki

Ghaderi

et al. 2011

Pathol. Oncol. Res.

View full text Add to dashboard Cite

show abstract

“…iDCs may play a role in CD56 1 NK cell recruitment, proliferation and inhibitory receptor expression (Figure 2a) as shown by CD56 1 NK cell and decidual iDC coculture, demonstrating that only one-third of NK cells proliferated in contact with iDC cells. 11 This suggests a selective expansion of NK cells by iDCs that is beneficial for pregnancy outcome. Additionally, NK cells proliferate and increase inhibitory receptor expression in response to iDC-derived IL-15.…”

Section: Nk/dc Liaison At the Fetomaternal Interfacementioning

confidence: 99%

“…21 DC-SIGN 1 DCs are also able to secrete IL-15 during decidualization and embryo implantation. 11,22 This secretion then recruits decidual NK cells to the endometrium 23 and upregulates CD56 expression. 24 Previous works state that decidua tissues from spontaneous abortions contain fewer DC-SIGN 1 iDCs compared with normal decidua, and iDC maturation and migration out of the decidual tissue to initiate an immune response might explain this phenomenon.…”

Section: Human Dcsmentioning

confidence: 99%

“…Additionally, NK cells proliferate and increase inhibitory receptor expression in response to iDC-derived IL-15. 11 The CD94/NKG2A inhibitory receptor has the ability to bind HLA-E expressed by trophoblast cells, which results in trophoblast protection from NK cytotoxicity. 59 It also has been demonstrated that, using cells from spleen 51 and blood, 53 immature DCs express IL-15Ra on their surfaces and IL15Ra is upregulated in mDCs.…”

Section: Nk/dc Liaison At the Fetomaternal Interfacementioning

confidence: 99%

“…Human iDCs can induce NK cell proliferation and cytotoxicity, and, reciprocally, NK cells can induce apoptotic DC death. 6,11 Activated NK cells kill decidual iDCs through apoptosis, which benefits normal pregnancy by preventing the formation of mature dendritic cells (mDCs) 12 and controlling unwanted Th1 immune responses. 6 Although it is clear that the interaction between DC and NK cells is important for a healthy pregnancy, the current literature lacks a comprehensive summary on this topic.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Liaison between natural killer cells and dendritic cells in human gestation

et al. 2014

View full text Add to dashboard Cite

A successful pregnancy relies on immunological adaptations that allow the fetus to grow and develop in the uterus, despite being recognized by maternal immune cells. Among several immunocompetent cell types present within the human maternal/fetal interface, DC-SIGN 1 dendritic cells (DCs) and CD56 1 natural killer (NK) cells are of major importance for early pregnancy maintenance, not only generating maternal immunological tolerance but also regulating stromal cell differentiation. Previous reports show the presence of NK-DC cell conjugates in first trimester human decidua, suggesting that these cells may play a role in the modulation of the local immune response within the uterus. While effective immunity is necessary to protect the mother from harmful pathogens, some form of tolerance must be activated to avoid an immune response against fetal antigens. This review article discusses current evidence concerning the functions of DC and NK cells in pregnancy and their liaison in human decidua.

show abstract

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani

Biswas

Galdiero

et al. 2012

The Journal of Pathology

Self Cite

1,941

1,589

View full text Add to dashboard Cite

Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2-like activation mode. Macrophages are credited with an essential role in remodelling during ontogenesis. In extraembryonic life, under homeostatic conditions, the macrophage trophic and remodelling functions are recapitulated in tissues such as bone, mammary gland, decidua and placenta. In pathology, macrophages are key components of tissue repair and remodelling that occur during wound healing, allergy, parasite infection and cancer. Interaction with cells bearing stem or progenitor cell properties is likely an important component of the role of macrophages in repair and remodelling. These properties of cells of the monocyte-macrophage lineage may represent a tool and a target for therapeutic exploitation.

show abstract

ORIGINAL ARTICLE: Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells

Abstract: These results suggest that decidual CD1a(+) cells regulate and shape NK cell function more profoundly than CD83(+) cells in decidua.

Cited by 42 publications

References 28 publications

CD1a and CD1d Genes Polymorphisms in Breast, Colorectal and Lung Cancers

CD1a and CD1d Genes Polymorphisms in Breast, Colorectal and Lung Cancers

Liaison between natural killer cells and dendritic cells in human gestation

Macrophage plasticity and polarization in tissue repair and remodelling

Contact Info

Product

Resources

About