Origin of the B/J, R/J, and Y/J strains of rabbits

Fox, R. R.

doi:10.1093/oxfordjournals.jhered.a108945

Cited by 40 publications

(74 citation statements)

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“…In support of this view, leupeptin which unlike aprotinin is a potent inhibitor of this enzyme [25], also reduced enzyme release. Our results demonstrate the importance of preventing endogenous proteolysis in studies on the phosphorylation of platelet membrane proteins and suggest that membrane-bound type I enzyme may normally mediate the CAMP-dependent phosphorylation of the membrane polypeptides thought to be important in the inhibition of platelet function by CAMP [2,3,7].…”

Section: Discussionmentioning

confidence: 78%

“…Histone (Type IIA) Human platelets, washed as described elsewhere 191, were finally resuspended in Tyrode's solution without albumin at a concentration of 5 X 10' ml-'. Samples of platelet suspension (3-5 ml) were mixed with the indicated additions, cooled to 0°C and lysed by sonication for 4 X 15 s [2]. Soluble and particulate fractions were isolated by centrifugation at 90 000 X g for 60 min at 4°C.…”

Section: Methodsmentioning

confidence: 99%

“…The 32P-labelled protein was isolated on glass fibre filters (Whatman F2832-24) and washed with 10% (w/v) trichloroacetic acid. The fdters were counted for 32P using Cerenkov radiation [2]. All assays were performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

“…The 32P-labelled polypeptides were detected by autoradiography and the relative amounts of 32P in them were quantitated by densitometry of the autoradiographs. The apparent molecular weights of labelled polypeptides were determined by parallel electrophoresis of protein markers [2]. Protein was determined according to Lowry et…”

Section: Methodsmentioning

confidence: 99%

“…Increases in platelet CAMP inhibit platelet function [ 11, an effect that is associated with the phosphorylation ofMr 22 000 and 24 000 membrane polypeptides in intact platelets [2,3]. The presence of both soluble [4-71 and membrane-bound [8] CAMP-dependent protein kinases has been reported in platelets.…”

Section: Introductionmentioning

confidence: 99%

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Subcellular distribution of cyclic AMP‐dependent protein kinase activity and of cyclic AMP‐binding proteins in human platelets

Salama

Haslam

1981

FEBS Letters

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Section: Discussionmentioning

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Subcellular distribution of cyclic AMP‐dependent protein kinase activity and of cyclic AMP‐binding proteins in human platelets

Salama

Haslam

1981

FEBS Letters

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Frequency of congenital abnormalities and of anatomical variations among JAX rabbits

Crary

Fox

1980

Teratology

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The frequency of congenital abnormalities and anatomical variations as observed among JAX rabbits is reported. Data were drawn from 32,082 inbred and partially inbred rabbits and 3,208 hybrids from the colony of the Jackson Laboratory over an eight-year period. Data reported here include stillbirths, rabbits dying from natural causes, and those killed for specific experimental regimens. Frequency data are based on the number of abnormalities observed in each category as a function of the total number of animals necropsied. This is approximately 95% of the animals born during the eight-year period and gives the frequency of abnormalities within each category rather than the number of individuals with one or more abnormalities. Anatomical variations have been found in almost all organ systems of JAX rabbits. Their presence adds to our knowledge of the characteristics of these strains, a knowledge that is critical to the understanding of the results of experimental manipulation or for determination of the presence of new mutations. There is considerable between-strain variation. Where frequencies are relatively high, the conditions are either known or suspected to be of genetic origin. Most of the anomalies are not deleterious, or their frequency is so low as to cause no problems within the colony. Hybrid populations have substantially fewer anomalies than do the parental strains. Where frequency is relatively high, it tends to be intermediate between the parental strains.

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Rabbit linkage group VIII: The alleles of the prt gene

1983

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The prt gene which is linked to the rabbit immunoglobulin kappa-light chain gene, ab, has two phenotypes, PRT+ and PRT-. These phenotypes can be distinguished only when serum proteins from different rabbits are separated by polyacrylamide gel electrophoresis. The serum protein profiles for PRT+ rabbits show a band that is located on the anodal side of transferrin. This band is missing in the serum profiles of PRT- rabbits. However, the PRT protein is present in these rabbits. An antiserum which reacts with PRT from PRT+ rabbits detects two electrophoretic variants of PRT which are located in areas of the polyacrylamide gel obscured by other serum proteins. These results and other suggest that the prt gene has three alleles, the prta allele encoding the protein found in PRT+ rabbits and the prtb and prtc alleles encoding the two electrophoretic variants found in PRT- rabbits.

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Origin of the B/J, R/J, and Y/J strains of rabbits

Abstract: The inbreeding of strains B/J, Y/J, and R/J, formerly designated ACCR(B), ACCR(Y), and ACCR(R), was started by full brother X sister inbreeding by C. Cohen to test the effect of inbreeding on the selective value of the different blood group genes.

Cited by 40 publications

References 0 publications

Subcellular distribution of cyclic AMP‐dependent protein kinase activity and of cyclic AMP‐binding proteins in human platelets

Subcellular distribution of cyclic AMP‐dependent protein kinase activity and of cyclic AMP‐binding proteins in human platelets

Frequency of congenital abnormalities and of anatomical variations among JAX rabbits

Rabbit linkage group VIII: The alleles of the prt gene

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