Origin of Terrestrial Bioorganic Homochirality and Symmetry Breaking in the Universe

Takahashi, Jutaro; Kobayashi, Kensei

doi:10.3390/sym11070919

Cited by 29 publications

(30 citation statements)

References 47 publications

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“…Questions related to the origin of mirror asymmetry in the world of carbon compounds in nature are continuously discussed in the scientific literature [1][2][3][4][5][6][7][8][9][10]. Here we focus on the analysis of the central role played by chirality in the self-organization of living matter.…”

Section: Physical Bases and Biological Functionality Of Sign-alternatmentioning

confidence: 99%

“…The origin and potential role of chiral asymmetry in biology have attracted the attention of the research community throughout the years [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Although, at the macroscopic level, nonbiological structures with a homochiral molecular basis are not known, living organisms have been engaged in a unique experiment of creating stable homochiral systems.…”

Section: Introductionmentioning

confidence: 99%

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Chiral Dualism as an Instrument of Hierarchical Structure Formation in Molecular Biology

Твердислов

Malyshko

2020

Symmetry

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The origin of chiral asymmetry in biology has attracted the attention of the research community throughout the years. In this paper we discuss the role of chirality and chirality sign alternation (L-D-L-D in proteins and D-L-D-L in DNA) in promoting self-organization in biology, starting at the level of single molecules and continuing to the level of supramolecular assemblies. In addition, we also discuss chiral assemblies in solutions of homochiral organic molecules. Sign-alternating chiral hierarchies created by proteins and nucleic acids are suggested to create the structural basis for the existence of selected mechanical degrees of freedom required for conformational dynamics in enzymes and macromolecular machines. Author Contributions: Conceptualization, V.A.T.; investigation, E.V.M.; writing-original draft preparation, V.A.T. and E.V.M. All authors have read and agreed to the published version of the manuscript.

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Section: Physical Bases and Biological Functionality Of Sign-alternatmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chiral Dualism as an Instrument of Hierarchical Structure Formation in Molecular Biology

Твердислов

Malyshko

2020

Symmetry

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“…On the other hand, scientists have long argued that several kinds of circularly polarized electromagnetic sources, including γ-ray, X-ray, and vacuum-UV in the universe, are responsible for the biomolecular handedness [4][5][6][7][8][9][13][14][15][16]. Alternatively, a subtle imbalance of L-and D-amino acids as tiny chiral chemical seeds significantly catalyze asymmetric chemical reactions to yield carbohydrates with a high ee, leading to the handed biomolecular world [48]; a nearly racemic substance in 10 −5 % ee attained a nearly ~100% ee when the Soai reaction was regarded as a testable model of the chemical evolution of chirality in prebiotic eons [143,144].…”

Section: Extraterrestrial Origins Of Circularly Polarized Radiation Sourcesmentioning

confidence: 99%

Resonance in Chirogenesis and Photochirogenesis: Colloidal Polymers Meet Chiral Optofluidics

Fujiki

2021

Symmetry

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Metastable colloids made of crystalline and/or non-crystalline matters render abilities of photonic resonators susceptible to chiral chemical and circularly polarized light sources. By assuming that μm-size colloids and co-colloids consisting of π- and/or σ-conjugated polymers dispersed into an optofluidic medium are artificial models of open-flow, non-equilibrium coacervates, we showcase experimentally resonance effects in chirogenesis and photochirogenesis, revealed by gigantic boosted chiroptical signals as circular dichroism (CD), optical rotation dispersion, circularly polarized luminescence (CPL), and CPL excitation (CPLE) spectral datasets. The resonance in chirogenesis occurs at very specific refractive indices (RIs) of the surrounding medium. The chirogenesis is susceptible to the nature of the optically active optofluidic medium. Moreover, upon an excitation-wavelength-dependent circularly polarized (CP) light source, a fully controlled absolute photochirogenesis, which includes all chiroptical generation, inversion, erase, switching, and short-/long-lived memories, is possible when the colloidal non-photochromic and photochromic polymers are dispersed in an achiral optofluidic medium with a tuned RI. The hand of the CP light source is not a determining factor for the product chirality. These results are associated with my experience concerning amphiphilic polymerizable colloids, in which, four decades ago, allowed proposing a perspective that colloids are connectable to light, polymers, helix, coacervates, and panspermia hypotheses, nuclear physics, biology, radioisotopes, homochirality question, first life, and cosmology.

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“…The other important and attractive topic yet unsolved is the origin of homochirality in the earth-why natural amino acids are the L-form while D-forms are enriched for sugars [48]. Since the enrichment of one isomer was found not only in the earth, but also in some meteorites [49], the cosmic scenario has been supported by many works, and may give a convincing answer to the origin of homochirality.…”

Section: Of 28mentioning

confidence: 99%

Interactions of Single Particle with Organic Matters: A Facile Bottom-Up Approach to Low Dimensional Nanostructures

Sakaguchi¹,

Kamiya²,

Sakurai³

et al. 2020

QuBS

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A particle induces a pack of chemical reactions in nanospace: chemical reactions confined into extremely small space provide an ultimate technique for the nanofabrication of organic matter with a variety of functions. Since the discovery of particle accelerators, an extremely high energy density can be deposited, even by a single isolated particle with MeV-ordered kinetic energy. However, this was considered to cause severe damages to organic molecules due to its relatively small bond energies, and lack of ability to control the reactions precisely to form the structures while retaining physico-chemical molecular functionalities. Practically, the severely damaged area along a particle trajectory: a core of a particle track has been simply visualized for the detection/dosimetry of an incident particle to the matters, or been removed to lead nanopores and functionalized by refilling/grafting of fresh organic/inorganic materials. The use of intra-track reactions in the so-called “penumbra” or “halo” area of functional organic materials has been realized and provided us with novel and facile protocols to provide low dimensional nano-materials with perfect size controllability in the 21st century. These protocols are now referred to as single particle nanofabrication technique (SPNT) and/or single particle triggered linear polymerization technique (STLiP), paving the way towards a new approach for nanomaterials with desired functionalities from original molecules. Herein, we report on the extremely wide applicability of SPNT/STLiP protocols for the future development of materials for opto-electronic, catalytic, and biological applications among others.

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Origin of Terrestrial Bioorganic Homochirality and Symmetry Breaking in the Universe

Cited by 29 publications

References 47 publications

Chiral Dualism as an Instrument of Hierarchical Structure Formation in Molecular Biology

Chiral Dualism as an Instrument of Hierarchical Structure Formation in Molecular Biology

Resonance in Chirogenesis and Photochirogenesis: Colloidal Polymers Meet Chiral Optofluidics

Interactions of Single Particle with Organic Matters: A Facile Bottom-Up Approach to Low Dimensional Nanostructures

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