Origin of Sepsis Associated with the Short-Term Mortality of Patients: A Retrospective Study Using the eICU Collaborative Research Database

Li, Qinglin; Tong, Yingmu; Wang, Hai; Ren, Jie; Sinan, Liu; Liu, Tong; Qu, Kai; Liu, Chang; Zhang, Jingyao

doi:10.2147/ijgm.s345050

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…In recent years, a series of risk factors have been identified as predictors of death from septic shock, including old age, serum lactate level, red blood cell distribution width, blood urea nitrogen level, creatinine level, and SOFA score [25][26][27][28][29][30] . Despite the development of therapeutic agents and strategies for treating septic shock, the mortality rate remains consistently high among critically ill patients 4,[31][32][33][34] . Therefore, there is an urgent need to identify more effective indicators for evaluating outcomes of septic shock.…”

Section: Discussionmentioning

confidence: 99%

Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database

Nan,

Huang,

Wan

et al. 2023

Sci Rep

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This study aimed to investigate the relationship between serum phosphate levels, changes in serum phosphate levels, and 28-day mortality in patients with septic shock. In this retrospective study, data were collected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database between 2008 and 2019. Patients were divided into three groups according to the tertiles of serum phosphate levels. Kaplan–Meier curves and log-rank test analyses were used for survival analysis. Multivariate logistic regression, and restricted cubic spline (RCS) curve were used to explore the association between serum phosphate, delta serum phosphate levels and 28-day mortality. In total, 3296 patients with septic shock were included in the study, and the 28-day mortality was 30.0%. Serum phosphate levels were significantly higher in the non-survivor group than in the survivor group. The Kaplan–Meier curves showed significant differences among the three groups. Multivariate logistic regression analysis and the RCS curve showed that serum phosphate levels were independently and positively associated with the 28-day mortality of septic shock. Non-survivors had higher delta serum phosphate levels than survivors. Survival analysis showed that patients with higher delta serum phosphate levels had higher 28-day mortality. A non-linear relationship was detected between delta serum phosphate and 28-day mortality with a point of inflection at − 0.3 mg/dL. Serum phosphate levels were positively and independently associated with 28-day mortality in septic shock. Delta serum phosphate level was a high-risk factor for patients with septic shock.

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Section: Discussionmentioning

confidence: 99%

Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database

Nan,

Huang,

Wan

et al. 2023

Sci Rep

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“…Two studies from China compared lung and abdominal sepsis; one showed lung infection was an independent risk factor for worse 1-year outcome and quality of life, while the other reported the complete opposite finding. 28 , 29 In our study, lung infection was shown to be associated with both increasing 30-day and 3-year mortality when compared with infection from a non-lung source.…”

Section: Discussionmentioning

confidence: 51%

Sepsis in a Combined Medical and Surgical High Dependency/Intensive Care Unit in Singapore: A Cohort Study and Survival Analysis

Xiao¹,

Khan²,

Ow³

et al. 2022

IJGM

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Background Sepsis is a common indication for intensive care unit (ICU) admission and is associated with significant mortality and morbidity. The aim of our study was to first assess the incidence, severity, short-term and long-term mortality of sepsis in a combined medical and surgical high dependency/ ICU in Singapore, and to identify factors associated with increasing short-term and long-term mortality. Methods All admissions from July 1 to December 31, 2017 were retrospectively screened and clinical data were collected. Patients were followed up until 3 years post ICU admission. Results Of a total 1526 admissions, 281 had infection at ICU admission, and 254 (16.6%) fulfilled sepsis-3 criteria for sepsis. A total of 141 (9.2%) had septic shock. The 30-day, 1-year, 2-year and 3-year mortality of sepsis patients were 19.3%, 25.2%, 30.3% and 32.3%, respectively. Lung was the most common site of infection. Compared with 30-day sepsis survivors, non-survivors were older (median age 70 vs 63, P <0.001), had higher percentage of lung infection (65.3% vs 36.1%, P <0.05), higher admission Sequential Organ Failure Assessment (SOFA) score (median 9 vs 5, P <0.001), and longer ICU stay (median days: 4 vs 3, P = 0.037). In stepwise Cox regression analysis, lung infection was an independent risk factor for both increasing 30-day and 3-year mortality. Immunocompromised host, increasing age and SOFA score were associated with higher 30-day mortality. Diabetes, admission quick Sequential Organ Failure Assessment (qSOFA) score >1 and unplanned ICU re-admission were associated with increasing 3-year mortality in 30-day survivors. Conclusion Our retrospective cohort single center study first reported sepsis admission incidence of 16.6% in a combined medical and surgical high dependency/ICU in Singapore, with significant short-term and long-term mortality. Lung infection was an independent risk factor for both 30-day and 3-year mortality.

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“…While abdominal infection constitutes the second-most common cause of hospitalized sepsis, it has the greatest potential for morbidity and mortality (17,19). As observed by Volakli et al (19), critically ill patients with abdominal infections were more commonly admitted in septic shock and more likely to experience early coagulation and renal failure.…”

Section: Discussionmentioning

confidence: 99%

“…While the abdomen is the second most common source for sepsis behind the lung, it has the highest associated mortality (17,18). Patients with intra-abdominal infection are more likely to develop septic shock, coagulation failure, and renal failure compared with patients with respiratory infection (19).…”

Section: Introductionmentioning

confidence: 99%

Endothelial Glycocalyx Shedding in Intra-Abdominal Sepsis: A Feasibility Study

Carmichael

Appelbaum²,

Renaldo

et al. 2023

Shock

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Background: The endothelial glycocalyx layer (EGL) is a complex meshwork of glycosaminoglycans and proteoglycans that protect the vascular endothelium. Cleavage or shedding of EGL-specific biomarkers, such as hyaluronic acid (HA) and syndecan-1 (SDC-1, CD138) in plasma, have been shown to be associated with poor clinical outcomes. However, it is unclear whether levels of circulating EGL biomarkers are representative of the EGL injury within the tissues. The objective of the present feasibility study was to describe a pathway for plasma and tissue procurement to quantify EGL components in a cohort of surgical patients with intra-abdominal sepsis. We sought to compare differences between tissue and plasma EGL biomarkers and to determine whether EGL shedding within the circulation and/or tissues correlated with clinical outcomes. Methods: This was a prospective, observational, single-center feasibility study of adult patients (N = 15) with intra-abdominal sepsis, conducted under an approved institutional review boards. Blood and resected tissue (pathologic specimen and unaffected peritoneum) samples were collected from consented subjects at the time of operation and 24–48 hours after surgery. Endothelial glycocalyx layer biomarkers (i.e., HA and SDC-1) were quantified in both tissue and plasma samples using a CD138 stain and ELISA kit, respectively. Pairwise comparisons were made between plasma and tissue levels. In addition, we tested the relationships between measured EGL biomarkers and clinical status and patient outcomes. Results: Fifteen patients with intra-abdominal sepsis were enrolled in the study. Elevations in EGL-specific circulating biomarkers (HA, SDC-1) were positively correlated with postoperative SOFA scores and weakly associated with resuscitative volumes at 24 hours. Syndecan-1 levels from resected pathologic tissue significantly correlated with SOFA scores at all time points (R = 0.69 and P < 0.0001) and positively correlated with resuscitation volumes at 24 hours (R = 0.41 and P = 0.15 for t = 24 hours). Tissue and circulating HA and SDC-1 positively correlated with SOFA >6. Conclusions: Elevations in both circulating and tissue EGL biomarkers were positively correlated with postoperative SOFA scores at 24 hours, with resected pathologic tissue EGL levels displaying significant correlations with SOFA scores at all time points. Tissue and circulating EGL biomarkers were positively correlated at higher SOFA scores (SOFA > 6) and could be used as indicators of resuscitative needs within 24 hours of surgery. The present study demonstrates the feasibility of tissue and plasma procurement in the operating room, although larger studies are needed to evaluate the predictive value of these EGL biomarkers for patients with intra-abdominal sepsis.

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Origin of Sepsis Associated with the Short-Term Mortality of Patients: A Retrospective Study Using the eICU Collaborative Research Database

Cited by 4 publications

References 28 publications

Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database

Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database

Sepsis in a Combined Medical and Surgical High Dependency/Intensive Care Unit in Singapore: A Cohort Study and Survival Analysis

Endothelial Glycocalyx Shedding in Intra-Abdominal Sepsis: A Feasibility Study

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