Origin of primary adrenal lymphoma and predisposing factors for primary adrenal insufficiency in primary adrenal lymphoma

Reddy, Sagili Vijaya Bhaskar; Prabhudesai, Shashank; Gnanasekaran, Babu

doi:10.4103/2230-8210.85604

Cited by 12 publications

(9 citation statements)

References 5 publications

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“…It is supported by more frequent development of adrenal failure in patients with lymphoma than in patients with bilateral adrenal metastases. Namely, adrenal failure occurs in 1% of patients with adrenal metastasis and only when more than 90% of the adrenal tissue is destroyed 10 . In contrast, a very high frequency of primary adrenal failure (60-70%) has been reported in patients with PAL, including patients with mildly enlarged adrenal glands 9,10 .…”

Section: Discussionmentioning

confidence: 99%

Double-hit primary unilateral adrenal lymphoma with good outcome

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Double-hit primary unilateral adrenal lymphoma with good outcome

et al. 2014

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“…There are somewhere around seventy endocrine superspecialty postgraduates who are completing the training every year, i.e., we are having one newly trained endocrinologist every year to cater a population of roughly 2 million. [9]…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis and management of primary adrenal insufficiency needs a high degree of suspicion, acumen, knowledge about adrenal disorders, and a protocol-based approach. [8910] CAH, an autosomal recessive disorder of defective steroid genesis, is as common as 1/10,000–1/20,000 for salt wasting/simple virilizing. CAH and for the milder varieties such as nonclassical CAH (NCCAH), the incidence is 1/1000 cases.…”

Section: Introductionmentioning

confidence: 99%

Study of awareness of adrenal disorders among interns and postgraduate students of Hamidia Hospital, Bhopal

Chittawar

Dubey

Sharma

et al. 2017

Indian J Endocr Metab

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Introduction:Adrenal disorders could be a life-threatening emergency, hence requires immediate therapeutic management. For this awareness regarding its diagnosis, management, and treatment is prime important.Aims and Objective:To study the awareness of adrenal disorders among interns and postgraduates students of Hamidia Hospital, Bhopal.Materials and Methods:A cross-sectional questionnaire-based study was performed. Fifty-six participants, i.e., 1st, 2nd, and 3rd years postgraduate residents of general medicine (n = 14 × 3) and interns (n = 14) were included in the study. There were 12 questions on adrenal insufficiency, adrenal adenoma, congenital adrenal hyperplasia (CAH), nonclassical CAH (NCCAH), pheochromocytoma, and Conn's syndrome. One mark was awarded for each correct response.Results:In the present study, 14 (25%) participants scored < 5 marks, 33 (58.9%) scored between 6 and 9, and 9 (16.1%) scored between 10 and 12. The mean score among the participants was 6.38 ± 2.505, with a range from 2 to 11 marks. The number of correct answers by postgraduates residents of 1st year was 101, 2nd year was 95, and 3rd year was 93 and interns scored 68 out of total 168 questions in each group. Mean awareness score for residents of 1st, 2nd, 3rd years participants and interns was 7.21 ± 2.806, 6.79 ± 2.119, and 6.64 ± 2.818 and 6.63 ± 2.505, respectively. Most of the participants recorded correct responses related to diagnosis (57.7%) followed by responses related to treatment (64.3%). Answers to a question regarding how commonly is adrenal insufficiency diagnosed in medical Intensive Care Unit, none of the individuals responded correctly.Conclusion:There was a lack of awareness regarding diagnosis, management, and treatment of adrenal disorders in central India. We need to prioritize training related to these illnesses in our postgraduate teaching curriculum in practice.

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“…Usually most often adrenal lymphomas present with bilateral tumours and symptoms of adrenal insufficiency 1–7. The aetiopathogenesis is still unknown, although frequent association with autoimmune diseases and immunodeficiency status is assessed 8. Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype 1–7.…”

Section: Discussionmentioning

confidence: 99%

Adrenal gland non-Hodgkin's lymphoma in a patient with pulmonary adenocarcinoma

D’Antonio

Addesso²,

Caleo

et al. 2013

BMJ Case Reports

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Although primary neoplasms of adrenal gland are uncommon, adrenal metastases are frequently encountered in patients with malignancy, and lung is the most common primary tumour site. Among primary tumours of the adrenal gland non-Hodgkin’s lymphoma (NHL) is a very rare entity. We describe a case of a 79-year-old man with a previous diagnosis of adenocarcinoma of the lung who presented after 2 years with a unilateral adrenal gland mass. A solitary metastasis from pulmonary carcinoma was suspected and a laparoscopic adrenalectomy was performed. Histological examination revealed a diffuse large B-cell NHL. The patient was treated with CHOP regimen plus rituximab and a total remission was achieved. After an 8-month follow-up the patient was free of disease. This is the first reported case of a rare non-synchronous tumoral combination involving lung and adrenal gland, emphasising at the incidental discovery of the NHL during a procedure performed for a pulmonary adenocarcinoma.

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Origin of primary adrenal lymphoma and predisposing factors for primary adrenal insufficiency in primary adrenal lymphoma

Cited by 12 publications

References 5 publications

Double-hit primary unilateral adrenal lymphoma with good outcome

Double-hit primary unilateral adrenal lymphoma with good outcome

Study of awareness of adrenal disorders among interns and postgraduate students of Hamidia Hospital, Bhopal

Adrenal gland non-Hodgkin's lymphoma in a patient with pulmonary adenocarcinoma

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