Origin of Microglia: Current Concepts and Past Controversies

Ginhoux, Florent; Prinz, Marco

doi:10.1101/cshperspect.a020537

Cited by 331 publications

(277 citation statements)

References 127 publications

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“…SC: Stem cell; NSC: Neural stem cells; RG: Radial glia; BP: Basal progenitor; YSMP: Yolk sac macrophage precursor; MP: Microglial precursor; HSC: Hematopoietic stem cell; BMM/P: Bone marrow monocyte/progenitor. Data from [82,[119][120][121][122][123][124].…”

Section: Why Should Glial Cell Size Be Constrained?mentioning

confidence: 99%

You Do Not Mess with the Glia

Herculano‐Houzel

Santos

2018

Neuroglia

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Vertebrate neurons are enormously variable in morphology and distribution. While different glial cell types do exist, they are much less diverse than neurons. Over the last decade, we have conducted quantitative studies of the absolute numbers, densities, and proportions at which non-neuronal cells occur in relation to neurons. These studies have advanced the notion that glial cells are much more constrained than neurons in how much they can vary in both development and evolution. Recent evidence from studies on gene expression profiles that characterize glial cells-in the context of progressive epigenetic changes in chromatin during morphogenesis-supports the notion of constrained variation of glial cells in development and evolution, and points to the possibility that this constraint is related to the late differentiation of the various glial cell types. Whether restricted variation is a biological given (a simple consequence of late glial cell differentiation) or a physiological constraint (because, well, you do not mess with the glia without consequences that compromise brain function to the point of rendering those changes unviable), we predict that the restricted variation in size and distribution of glial cells has important consequences for neural tissue function that is aligned with their many fundamental roles being uncovered.

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Section: Why Should Glial Cell Size Be Constrained?mentioning

confidence: 99%

You Do Not Mess with the Glia

Herculano‐Houzel

Santos

2018

Neuroglia

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“…Microglia originate from erythromyeloid progenitors in the yolk sac and populate the CNS during early embryonic development (8). Microglia actively survey the surrounding microenvironment with dynamic processes.…”

Section: Introductionmentioning

confidence: 99%

Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease

Satoh

Kino

Yanaizu

et al. 2017

IRDR

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“…In contrast to astrocytes and oligodendrocytes, microglia are mesodermal in origin and are generated in the yolk sac during embryogenesis, at E7.5 in the mouse (Aguzzi et al, 2013;Ginhoux and Prinz, 2015;Casano and Peri, 2015). First, hematopoietic stem cells in the yolk sac become primitive macrophages, and then these primitive macrophages migrate to the developing CNS and become microglia.…”

Section: Origins and Specification Of Gliamentioning

confidence: 99%

“…Both astrocytes and microglia have also been implicated in numerous neurological and psychiatric diseases (e.g. ALS, Alzheimer's disease and Parkinson's disease; Phatnani and Maniatis, 2015;Ginhoux and Prinz, 2015). In most cases, it is incompletely understood whether their contributions to these diseases are due to toxic gain of functions (e.g.…”

Section: Central Roles Of Glia In Injury Regeneration and Diseasementioning

confidence: 99%

Glia in mammalian development and disease

2015

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Glia account for more than half of the cells in the mammalian nervous system, and the past few decades have witnessed a flood of studies that detail novel functions for glia in nervous system development, plasticity and disease. Here, and in the accompanying poster, we review the origins of glia and discuss their diverse roles during development, in the adult nervous system and in the context of disease.

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Origin of Microglia: Current Concepts and Past Controversies

Cited by 331 publications

References 127 publications

You Do Not Mess with the Glia

You Do Not Mess with the Glia

Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease

Glia in mammalian development and disease

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