This paper described a hypothesis about phenomenon those may have occurred early in the evolution of life or pre-life to reveal how every creature of the Earth has strong preference for specific chirality. Thread of helical molecule cannot be replicated by using a casting mold at once. Replication of creature has been carried out by DNA. The interactions among molecules of DNA are able to estimate from stereo structure of DNA. There are a D-typed chiral strand and a L-typed chiral strand linked by bases in a DNA. Those strands are generated simultaneously in the vicinity, but two will not coalesce due to the different typed chirality of the helix. The paired strands of DNA are able to become a representative of a series of amino acids for a protein i.e., DNA is able to memorize the information of replication of a protein. If amino acid molecules will be bonded with other amino acid at random timing, the alignment of amino acids is randomized in the protein. In such case, the replication is not accurate, and it will be eliminated by natural selection. Current amino acids alignment is stored by using genetic code in DNA, and replication of protein is constructed by using genetic codes sequences sequentially. In the double helix of DNA, there are leading strands and lagging strands, and the two strands proceed in rotationally opposite directions to find matched base pairs, the protein is formed when two genetic codes are in a key-keyhole relationship. The processing is carried out by amino acid units. The nucleobase ciphers of codon and anticodon represent amino acids at matching processing. The chirality of biomolecules takes one of the most important roles in the activities of creature in the Earth.