Origin of immature teratoma of the ovary

Ohama, Koso; Nomura, Kazushi; Okamoto, Eri; Fukuda, Yoshihiro; Ihara, Toshihiko; Fujiwara, Atsushi

doi:10.1016/s0002-9378(85)80088-0

Cited by 54 publications

(24 citation statements)

References 16 publications

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“…In contrast to this, the immature ovarian teratoma had allelic losses at all informative loci screened, confirming the notion that immature teratomas of the ovary may derive from the clonal proliferation of a germinal cell that had already undergone the first meiotic division (Parrington et al. 1984;Ohama et al. 1985).…”

Section: Loss O F Heterozygosity In One Ovarian Teratomasupporting

confidence: 64%

Loss of heterozygosity in human germinal tumors

Radice¹,

Lacerenza²,

Mondini³

et al. 1989

Cytogenet Genome Res

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The frequency of losses of heterozygosity has been investigated in 14 germinal tumors of the testis. Nonrandom deletion of whole or part of chromosome 11 was observed in four cases. In addition, loss of heterozygosity of all the informative loci analyzed was detected in one ovarian teratoma, indicating its post-meiotic origin. These results suggest that different genetic mechanisms (chromosomal deletions or meiotic segregation) that unmask putative recessive mutations are involved in the onset of germinal tumors.

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Section: Loss O F Heterozygosity In One Ovarian Teratomasupporting

confidence: 64%

Loss of heterozygosity in human germinal tumors

Radice¹,

Lacerenza²,

Mondini³

et al. 1989

Cytogenet Genome Res

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“…6,7 In contrast, ovarian dermoid cysts arise from the spontaneous activation of an ovarian oocyte resulting in the duplication of the maternal genome. 8 These abnormalities indicate that normal human development proceeds only when a complete complement of the paternal and maternal genomes is present.…”

Section: Introductionmentioning

confidence: 99%

Genomic Imprinting: Implications for Human Disease

Falls

Pulford

Wylie

et al. 1999

The American Journal of Pathology

326

210

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Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic expression. This parent-of-origin dependent phenomenon is a notable exception to the laws of Mendelian genetics. Imprinted genes are intricately involved in fetal and behavioral development. Consequently , abnormal expression of these genes results in numerous human genetic disorders including carcinogenesis. This paper reviews genomic imprinting and its role in human disease. Additional information about imprinted genes can be found on the Genomic Imprinting Website at http://www.geneimprint.com. (Am J Pathol 1999, 154:635-647)

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“…Similarly, in humans complete hydatidiform moles, which contain only paternal chromosomes, produce primarily placental tissue, whereas dermoid cysts, which contain only maternal chromosomes, produce primarily embryonic tissue (23,26). These findings suggested that the mammalian genome contains autosomal genes required for development that are only expressed from either the maternal or paternal allele.…”

Section: Imprint Gene Identificationmentioning

confidence: 98%

“…Imprinting has also been identified in maize (14), zebra fish (15), and a variety of other insects including Drosophila melanogaster in which the phenomenon has been referred to as parental effects (13,(16)(17)(18)(19). The viability of both gynogenic and androgenic flies and zebra fish (20)(21)(22) indicates, however, that imprinted genes are not as developmentally essential in these species as in mammals (23)(24)(25)(26).…”

Section: Imprint Gene Identificationmentioning

confidence: 99%

Imprinted genes as potential genetic and epigenetic toxicologic targets.

Murphy

Jirtle

2000

Environ Health Perspect

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Genomic imprinting is an epigenetic phenomenon in eutherian mammals that results in the differential expression of the paternally and maternally inherited alleles of a gene. Imprinted genes are necessary for normal mammalian development. This requirement has been proposed to have evolved because of an interparental genetic battle for the utilization of maternal resources during gestation and postnatally. The nonrandom requisite for monoallelic expression of a subset of genes has also resulted in the formation of susceptibility loci for neurobehavioral disorders, developmental disorders, and cancer. Since imprinting involves both cytosine methylation within CpG islands and changes in chromatin structure, imprinted genes are potential targets for dysregulation by epigenetic toxicants that modify DNA methylation and histone acetylation.

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Origin of immature teratoma of the ovary

Cited by 54 publications

References 16 publications

Loss of heterozygosity in human germinal tumors

Loss of heterozygosity in human germinal tumors

Genomic Imprinting: Implications for Human Disease

Imprinted genes as potential genetic and epigenetic toxicologic targets.

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