Origin of genetically encoded protein synthesis: A model based on selection for RNA peptidation

Wong, J. Tze‐Fei

doi:10.1007/bf01809445

Cited by 83 publications

(49 citation statements)

References 37 publications

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“…Still, before the advent of ritualized translation, amino acids and peptides could have boosted RNA protocells by enhancing catalytic potential (55,56) or regulating membrane permeability and transport (32). When speculating on the origin of translation, one should consider that a pentanucleotide (!)…”

Section: Origins Of Life: Three Early Phases Of Transitions To Cellsmentioning

confidence: 99%

Toward major evolutionary transitions theory 2.0

Szathmáry

2015

Proc. Natl. Acad. Sci. U.S.A.

325

343

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The impressive body of work on the major evolutionary transitions in the last 20 y calls for a reconstruction of the theory although a 2D account (evolution of informational systems and transitions in individuality) remains. Significant advances include the concept of fraternal and egalitarian transitions (lower-level units like and unlike, respectively). Multilevel selection, first without, then with, the collectives in focus is an important explanatory mechanism. Transitions are decomposed into phases of origin, maintenance, and transformation (i.e., further evolution) of the higher level units, which helps reduce the number of transitions in the revised list by two so that it is less top-heavy. After the transition, units show strong cooperation and very limited realized conflict. The origins of cells, the emergence of the genetic code and translation, the evolution of the eukaryotic cell, multicellularity, and the origin of human groups with language are reconsidered in some detail in the light of new data and considerations. Arguments are given why sex is not in the revised list as a separate transition. Some of the transitions can be recursive (e.g., plastids, multicellularity) or limited (transitions that share the usual features of major transitions without a massive phylogenetic impact, such as the microand macronuclei in ciliates). During transitions, new units of reproduction emerge, and establishment of such units requires high fidelity of reproduction (as opposed to mere replication).egalitarian transitions | fraternal transitions | multilevel selection | aggregative unit formation | recursive transitions T he book The Major Transitions in Evolution was published 20 y ago (1) and popularized 16 y ago (2). The impressive work accomplished by the interested community has made time ripe for a resynthesis of the field. In this paper, I outline the revised theory for transitions research while noting that the full account can be taken only in a new book. First, I present the key points of the theory, followed by an impressionist overview of some of the transitions, highlighting (without being all-inclusive) some of the most exciting findings pertinent to the major transitions in a revised list. In doing so, I rebuild some of the foundations of the theory. A scholarly account of all relevant contributions is beyond the scope of the present paper. For lack of space, I deliberately omit discussion on the origin of animal societies (3), except humans.

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Section: Origins Of Life: Three Early Phases Of Transitions To Cellsmentioning

confidence: 99%

Toward major evolutionary transitions theory 2.0

Szathmáry

2015

Proc. Natl. Acad. Sci. U.S.A.

325

343

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“…A number of hypotheses have been presented but none is completely satisfactory. The synthesis of semi-random polypeptides could have provided simple structural functions to ribozymes (see Di Giulio, 1998;Orgel, 1989;Wong, 1991). Furthermore, Orgel (1989) and Poole et al (1999) suggested aminoacylation could help facilitate replication by directly increasing the binding of the tRNA portion of the molecule to the replicase.…”

Section: An Early Role For Protein Synthesismentioning

confidence: 97%

Co-Evolution of the Genetic Code and Ribozyme Replication

Stevenson

2002

Journal of Theoretical Biology

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“…The origin of the unambiguous but degenerate nature of the genetic code lies in the use of such coding coenzyme handles (CCHs), according to our view (Szathmry, 1990c). The crucial difference between the CCH hypothesis and the similar, in many ways, idea of Wong (1991) about selection for RNA peptidation is that in the latter coding does not naturally emerge due to the fact that oligopeptides rather than amino acids are assumed to be linked to RNA.…”

Section: The Use Of Coenzymes: From the Rna World To The Protein Worlmentioning

confidence: 99%

“…Szathmry, 1999). As suggested by Wong (1991), primordial amino acids may have been N-linked, because the ester bond is too labile.…”

Section: The Use Of Coenzymes: From the Rna World To The Protein Worlmentioning

confidence: 99%

Fitness Landscapes, Error Thresholds, and Cofactors in Aptamer Evolution

Kun

Maurel

Santos

et al. 2006

The Aptamer Handbook

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Origin of genetically encoded protein synthesis: A model based on selection for RNA peptidation

Cited by 83 publications

References 37 publications

Toward major evolutionary transitions theory 2.0

Toward major evolutionary transitions theory 2.0

Co-Evolution of the Genetic Code and Ribozyme Replication

Fitness Landscapes, Error Thresholds, and Cofactors in Aptamer Evolution

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