Origin of Dengue Type 3 Viruses Associated With the Dengue Outbreak in Dhaka, Bangladesh, in 2000 and 2001

Podder, Goutam; Breiman, Robert F.; Azim, Tasnim; Thu, Hlaing Myat; Velathanthiri, Niluka; Quynh, Lê; Lowry, Kym; Aaskov, John

doi:10.4269/ajtmh.2006.74.263

Cited by 31 publications

(18 citation statements)

References 11 publications

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“…Broadcasting of the virus from India to Cambodia was also indicated with a significant BF value. On the other hand, Bangladesh and Myanmar were populated with GII viruses from South-east Asia as suggested earlier (Podder et al, 2006) and also shown from the present phylogeography studies. Further, dispersal of the virus from Sri Lanka to Africa and Central America was also supported by significant values of BF (Table S7A).…”

Section: Discussionsupporting

confidence: 68%

Influence of evolutionary events on the Indian subcontinent on the phylogeography of dengue type 3 and 4 viruses

Patil

Cherian

Walimbe

et al. 2012

Infection, Genetics and Evolution

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Section: Discussionsupporting

confidence: 68%

Influence of evolutionary events on the Indian subcontinent on the phylogeography of dengue type 3 and 4 viruses

Patil

Cherian

Walimbe

et al. 2012

Infection, Genetics and Evolution

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“…Similar studies in India suggest that genotype V of DENV-2 was replaced by genotype IV between 1967 and 1996 (Singh et al, 1999). DENV-3 strains isolated from Bangladesh in 2000 and 2001 were most closely related to recently emerged DENV-3 from neighboring Thailand and Myanmar, but distinct from those isolated in India and Sri Lanka (Podder et al, 2006). DENV-3, subtype III, which apparently originated in the Indian subcontinent, appears to have spread into Africa during the 1980s and from Africa into Latin America during the 1990s.…”

Section: Contributions Of Phylogenetics To the Understanding Of Dementioning

confidence: 86%

Molecular evolution of dengue viruses: Contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease

Weaver

Vasilakis

2009

Infection, Genetics and Evolution

395

380

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Dengue viruses (DENV) are the most important arboviral pathogens in tropical and subtropical regions throughout the world, putting at risk of infection nearly a third of the global human population. Evidence from the historical record suggests a long association between these viruses and humans. The transmission of DENV includes a sylvatic, enzootic cycle between nonhuman primates and arboreal mosquitoes of the genus Aedes, and an urban, endemic/epidemic cycle between Aedes aegypti, a mosquito with larval development in peridomestic water containers, and human reservoir hosts. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise of 4 antigenically distinct serotypes (DENV-1-4). Although they are nearly identical epidemiologically, the 4 DENV serotypes are genetically quite distinct. Utilization of phylogenetic analyses based on partial and/or complete genomic sequences has elucidated the origins, epidemiology (genetic diversity, transmission dynamics and epidemic potential), and the forces that shape DENV molecular evolution (rates of evolution, selection pressures, population sizes, putative recombination and evolutionary constraints) in nature. In this review, we examine how phylogenetics have improved understanding of DENV population dynamics and sizes at various stages of infection and transmission, and how this information may influence pathogenesis and improve our ability to understand and predict DENV emergence.

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“…The first identified epidemic of DF and dengue hemorrhagic fever (DHF) in Bangladesh, took place during the monsoon season of 2000, and resulted in 5,521 officially reported cases with 93 fatalities [17–18]. Based on molecular diagnostic testing of persons with acute disease, all four dengue serotypes have been found in circulation in recent years [19–21]. From 2000–2009, 91.0% of all reported dengue cases were from Dhaka making it the most endemic urban area of the country [22].…”

Section: Introductionmentioning

confidence: 99%

Dengue seroprevalence, seroconversion and risk factors in Dhaka, Bangladesh

Dhar-Chowdhury¹,

Paul²,

Haque³

et al. 2017

PLoS Negl Trop Dis

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BackgroundDengue virus (DENV) activity has been reported in Dhaka, Bangladesh since the early 1960s with the greatest burden of dengue fever and dengue hemorrhagic fever cases observed in 2000. Since this time, the intensity of dengue activity has varied from year to year, and its determining factors remained relatively unknown. In light of such gaps in knowledge, the main objectives of this study were to determine the magnitude of seroprevalence and seroconversion among the surveyed population, and establish the individual/household level risk factors for the presence of DENV antibodies among all age groups of target populations in the city of Dhaka.Methodology/Principal findingsConsidering the lack of fine scale investigations on the factors driving dengue activity in Bangladesh, a prospective cohort study involving serological surveys was undertaken with participant interviews and blood donation across the city of Dhaka in 2012. Study participants were recruited from 12 of 90 wards and blood samples were collected during both the pre-monsoon (n = 1125) and post-monsoon (n = 600) seasons of 2012. The findings revealed that the seroprevalence in all pre-monsoon samples was 80.0% (900/1125) while the seropositivity in the pre-monsoon samples that had paired post-monsoon samples was 83.3% (503/600). Of the 97 paired samples that were negative at the pre-monsoon time point, 56 were positive at the post-monsoon time point. This resulted in a seroprevalence of 93.2% (559/600) among individuals tested during the post-monsoon period. Seroprevalence trended higher with age with children exhibiting a lower seropositivity as compared to adults. Results from this study also indicated that DENV strains were the only flaviviruses circulating in Dhaka in 2012. A multivariate analysis revealed that age, possession of indoor potted plants, and types of mosquito control measures were significant factors associated with DENV seroprevalence; while attendance in public/mass gatherings, and use of mosquito control measures were significantly associated with DENV seroconversion after adjusting for all other variables.Conclusions/SignificanceOur study suggests that there is a high level of endemic dengue virus circulation in the city of Dhaka which has resulted in significant DENV seroprevalence among its residents. Seropositivity increased with age, however, a substantial proportion of children are at risk for DENV infections. Our serological analysis also documents considerable DENV seroconversion among study participants which indicates that a large proportion of the population in the city of Dhaka were newly exposed to DENV during the study period (pre-and post-monsoon 2012). High levels of seroconversion suggest that there was an intense circulation of DENV in 2012 and this may have resulted in a significant risk for viral associated illness. Findings of our study further indicated that home-based interventions, such as removing indoor potted plants and increased bed net use, in addition to vector control measures in public parks...

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Origin of Dengue Type 3 Viruses Associated With the Dengue Outbreak in Dhaka, Bangladesh, in 2000 and 2001

Cited by 31 publications

References 11 publications

Influence of evolutionary events on the Indian subcontinent on the phylogeography of dengue type 3 and 4 viruses

Influence of evolutionary events on the Indian subcontinent on the phylogeography of dengue type 3 and 4 viruses

Molecular evolution of dengue viruses: Contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease

Dengue seroprevalence, seroconversion and risk factors in Dhaka, Bangladesh

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