Origin of cardiomotor fibres in the dorsal nucleus of the vagus in the cat: a historical study

Calaresu, F. R.; Cottle, Merva K.

doi:10.1113/jphysiol.1965.sp007548

Cited by 48 publications

(12 citation statements)

References 19 publications

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“…This finding is consistent with the low counts of myelinated efferent fibres in cardiac branches of the cat (Agostoni et al 1957), and implies a similarly small number of cells of origin. This could explain the failure of others to record evoked potentials in the DNV following peripheral vagal stimulation (Urabe & Tsubokawa, 1960;Porter, 1963) and also the scarcity of axonal degeneration seen in cardiac vagal branches following lesions in the DNV (Calaresu & Cottle, 1964). On the other hand, the evidence does not exclude the possibility that, although some motor fibres to the heart may originate in it, the DNV is not the cell station of the cardio-inhibitory component of the vagus nerve.…”

Section: Discussionmentioning

confidence: 80%

“…The paucity of active efferent fibres revealing a modification of discharge associated with reflex bradyeardia, however, as well as the absence of a cardiac rhythm of discharge which has been reported by others, led to our decision to attempt to record directly from the cell bodies of the motor component of the nerve. On the basis of available histological evidence reviewed by Mitchell & Warwick (1955) and supported by recent studies in the cat (Mohiuddin, 1953;Calaresu & Cottle, 1964) vagal efferent fibres to the heart originate * Fellow of the Canadian Heart Foundation.…”

mentioning

confidence: 99%

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Electrical activity of efferent vagal fibres and dorsal nucleus of the vagus during reflex bradycardia in the cat

Calaresu¹,

Pearce²

1965

The Journal of Physiology

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Although there exists an extensive literature on primary vagal afferent discharges of cardiovascular origin (Paintal, 1963) there is a need for characterization of discharge patterns in vagal efferent fibres to the heart. Such information from peripheral nerve recordings might then allow the recognition, by exclusion, of related interneuronal activity in intramedullary recordings and thus aid the study of neural mechanisms of cardiomotor reflexes. Earlier attempts to record cardiomotor activity in cardiac branches of the vagus have yielded discharges of questionable origin because, at this level of the nerve, admixture with sympathetic efferents arising in both the stellate and inferior cervical ganglia (Cannon, Lewis & Britton, 1926) is unavoidable unless all peripheral connexions between the vagus and sympathetic nerves are cut. Relevant accounts do not contain assurance that this precaution was taken

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Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 99%

Electrical activity of efferent vagal fibres and dorsal nucleus of the vagus during reflex bradycardia in the cat

Calaresu¹,

Pearce²

1965

The Journal of Physiology

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“…Anatomical and physiological studies on several species have concluded that they may originate in the dorsal motor vagal nucleus, the nucleus ambiguus or in both of these nuclei (see Kosaka & Yagita, 1908;Husten, 1924;Getz & Sirnes, 1949;Szentogathai, 1952;Mitchell & Warwick, 1955;Calaresu & Cottle, 1965). Recently, McAllen & Spyer (1976, 1978 have provided electrophysiological evidence that vagal cardioinhibitory and bronchoconstrictor neurones with myelinated axons are located in the nucleus ambiguus of the cat.…”

Section: Introductionmentioning

confidence: 99%

“…However, it was not possible to determine whether the recordings were from primary afferent fibres or efferent neurones. So far, histological studies have failed to show unequivocally whether efferent cell bodies in the region of the dorsal motor vagal nucleus have axons in the cardiac and pulmonary branches of the vagus (Getz & Sirnes, 1949;Szentagothai, 1952;Calaresu & Cottle, 1965).…”

Section: Introductionmentioning

confidence: 99%

A Horseradish Peroxidase Study of Vagal Motoneurones With Axons in Cardiac and Pulmonary Branches of the Cat and Dog

et al. 1981

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SUMMARYThe location, within the brain stem, of vagal efferent neurones with axons in the cardiac and pulmonary branches of the cat, and the cardiac branch of the dog, have been defined. Horseradish peroxidase was applied to the cut central ends of these vagal branches and, after an appropriate time, sections of the brain stem were examined for labelled cell bodies. Labelled cell bodies were found ipsilaterally in the dorsal motor vagal nucleus, the nucleus ambiguus and in the reticular formation between these two nuclei. We suggest that the dual location for cell bodies of vagal axons may represent a separation of somata with myelinated and non-myelinated vagal axons to the nucleus ambiguus and the dorsal motor vagal nucleus respectively.

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“…In view of the close proximity of this nucleus to the dorsal nucleus of the vagus and to the nucleus ofthe tractus solitarius, which have been implicated in cardio-inhibitory responses (e.g. Calaresu & Pearce, 1965b;Calaresu & Cottle, 1965), it has been suggested by Smith (1965) that the NIc may be part of a descending hypothalamic pathway inhibitory to cardioinhibitory neurones in the medulla. Another finding, suggesting that the NIc may be involved in a descending sympathetic pathway, is that of evoked activity recorded simultaneously from the NIc and from the inferior cardiac nerve during cardio-acceleration elicited by electrical stimulation of the posterior hypothalamus (Alanis, Mascher & Miyamoto, 1966).…”

Section: Introductionmentioning

confidence: 99%

The mechanism of the cardio‐acceleration elicited by electrical stimulation of the parahypoglossal area in the cat

Calaresu¹,

Henry²

1970

The Journal of Physiology

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SUMMARY1. In chloralosed and in decerebrated cats localized electrical stimulation of a discrete parahypoglossal area (including the nucleus intercalatus and a discrete neighbouring region ventrolateral to the hypoglossal nucleus) elicited cardio-acceleration and arterial hypertension, either singly or together.2. The cardio-acceleratory response was decreased by intravenous administration of propranolol (2 mg/kg). In another group of experiments the response was abolished by acute bilateral cervical vagotomy but it was observed to return partially when stimulation was applied one or more hours after vagotomy. The hypertensive response was not affected by propranolol or by vagotomy.3. Evoked electrical activity with a latency of 3-10 msec was recorded from pre-and post-ganglionic sympathetic cardio-acceleratory nerves during stimulation of this region.4. These findings demonstrate the existence of a discrete medullary area which controls heart rate by activation of a sympathetic pathway and inhibition of a parasympathetic pathway.

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Origin of cardiomotor fibres in the dorsal nucleus of the vagus in the cat: a historical study

Cited by 48 publications

References 19 publications

Electrical activity of efferent vagal fibres and dorsal nucleus of the vagus during reflex bradycardia in the cat

Electrical activity of efferent vagal fibres and dorsal nucleus of the vagus during reflex bradycardia in the cat

A Horseradish Peroxidase Study of Vagal Motoneurones With Axons in Cardiac and Pulmonary Branches of the Cat and Dog

The mechanism of the cardio‐acceleration elicited by electrical stimulation of the parahypoglossal area in the cat

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