Origin of Bacteria in Bileduct Bile

Scott, Alastair; Khan, Gausal A.

doi:10.1016/s0140-6736(67)92231-3

Cited by 78 publications

(29 citation statements)

References 8 publications

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“…Cefoperazone, which was effective in vitro against P. aeruginosa isolated in this study, sterilized the bile of two patients harboring this agent. As reported previously, P. aeruginosa was observed exclusively in patients with cancer (1,5,10,36). Anaerobes were recovered from six patients.…”

Section: Discussionsupporting

confidence: 74%

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Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections

Bergeron

Mendelson

Harding

et al. 1988

Antimicrob Agents Chemother

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In a prospective, randomized, multicenter study, the efficacy and safety of cefoperazone and the combination ampicillin-tobramycin as initial therapy for patients with severe acute biliary tract infections were compared. Of 77 patients initially entered in the study, definite severe biliary tract infection was confirmed in 67. Sixty-four patients completed treatment. At the end of treatment, 35 of 36 (97%) patients given cefoperazone and 23 of 28 (82%) given ampicillin-tobramycin were cured of their infection (P = 0.07). Pathogens were recovered from the bile in 32 patients; microbiological cures were observed in 18 of 19 (94%) patients receiving cefoperazone and 8 of 13 (62%) receiving ampicillin-tobramycin (P = 0.03). Thirteen patients had septicemia. None (0%) of the eight septicemic patients from the cefoperazone group, but two of five (40%) from the ampicillin-tobramycin group, were clinical failures. Of the isolated pathogens, 51% were resistant to ampicillin, while the resistance rate was 4% for tobramycin and 1% for cefoperazone (P < 0.001). Biliary concentrations of cefoperazone were maintained at high levels-236 ± 87

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Section: Discussionsupporting

confidence: 74%

“…In fact, unless cholecystitis occurs in an older patient or is associated with cystic or common bile duct obstruction (1,10,36), the incidence of active infection is less than 50% (11,32).…”

Section: Discussionmentioning

confidence: 99%

Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections

Bergeron

Mendelson

Harding

et al. 1988

Antimicrob Agents Chemother

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“…Primary pathogenic events include a variety of parasitic infections whose life cycles may be solely luminal without a phase of tissue invasion (26). During biliary tract obstruction, the biliary tree is commonly secondarily infected with enteric bacteria (27). Thus, the normal and compromised biliary tract is subject to a variety of infectious assaults.…”

Section: Discussionmentioning

confidence: 99%

A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes.

Blumberg¹,

Koss²,

Story³

et al. 1995

J. Clin. Invest.

133

108

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“…Biliary infections are frequently seen in patients with obstructive jaundice [3,6,11], Although it has been suggested that an im paired function of the reticuloendothelial sys tem of the liver may play a major pathogenic role [2,5,8], the precise mechanism(s) lead ing to biliary sepsis in obstructive jaundice is not yet clear.…”

Section: Introductionmentioning

confidence: 99%

Decreased Clearance of <i>Escherichia col</i><i>i</i> from the Bile in Rats with Obstructive Jaundice

Tanaka¹,

Christensen

Rydén³

et al. 1985

Eur Surg Res

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Clearance of Escherichia coli from the bile was studied in 4 normal Sprague-Dawley rats and 4 rats with 3 weeks of obstruction of the common bile duct. ^I25I-radiolabelled heat-killed E. coli were injected into the common bile duct and the radioactivity of the bile monitored for 2 h. The radioactivity declined exponentially during the first 10 min. Bile samples collected from 2 to 15 min after injection showed higher amounts of radioactivity in all rats with biliary obstruction than in the normal rats. However, the clearance rate was higher in normal than in obstructed rats (p < 0.05). It was, therefore, concluded that the bacteria were cleared off the bile rapidly in normal rats by the function of a liver and/or a biliary tree. The present data, concerning the kinetic study of bacterial clearance from the biliary tract, indicates that the impaired clearance of bacteria in chronic biliary obstruction might be crucial for the development of biliary sepsis.

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Origin of Bacteria in Bileduct Bile

Cited by 78 publications

References 8 publications

Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections

Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections

A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes.

Decreased Clearance of <i>Escherichia col</i><i>i</i> from the Bile in Rats with Obstructive Jaundice

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