Origin of Adenohypophysial Lobes and Cells from Rathke’s Pouch in Chicken (<i>Gallus gallus</i>) and Japanese Quail (<i>Coturniz coturniz japonica</i>). Expression of Calcium‐Binding Proteins

Reyes, Ricardo; González, Marı́a José; Bello, Aixa R.

doi:10.1111/j.1439-0264.2007.00840.x

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…At HH16-18, the ADH pouch underlies the NH primordium and the prospective tuberal region (see sagittal sections, Figures 6E–I ; see also Bardet et al, 2010 ), where Pax6 and Cytokeratin-8 are expressed (Figures 6D,G,J ). Furthermore, we noted the onset of ADH regionalization into two domains, the future anterior and intermediate lobes (Sheng and Westphal, 1999 ; Rizzoti and Lovell-Badge, 2005 ; Reyes et al, 2008 ). Whereas Tcf4 and Pitx2 signals delineated the presumptive anterior part of the ADH (Figures 6E–G,J ), Six3 and Raldh3 expression appears restricted to the future intermediate ADH lobe, which underlies the presumptive NH or posterior pituitary lobe ( Six3 and Shh -positive domain; Figures 6H–J ).…”

Section: Resultsmentioning

confidence: 88%

Origin and early development of the chicken adenohypophysis

et al. 2015

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The adenohypophysis (ADH) is an important endocrine organ involved in the regulation of many physiological processes. The late morphogenesis of this organ at neural tube stages is well known: the epithelial ADH primordium is recognized as an invagination of the stomodeal roof (Rathke’s pouch), whose walls later thicken and differentiate as the primordium becomes pediculated, and then fully separated from the stomodeum. The primordium attaches to the pial surface of the basal hypothalamus, next to the neurohypophyseal field (NH; future posterior pituitary), from which it was previously separated by migrating prechordal plate (pp) cells. Once the NH evaginates, the ADH surrounds it and jointly forms with it the pituitary gland. In contrast, little is known about the precise origin of the ADH precursors at neural plate stages and how the primordium reaches the stomodeum. For that reason, we produced in the chicken a specific ADH fate map at early neural plate stages, which was amplified with gene markers. By means of experiments labeling the mapped presumptive ADH, we were able to follow the initial anlage into its transformation into Rathke’s pouch. The ADH origin was corroborated to be strictly extraneural, i.e., to lie at stage HH4/5 outside of the anterior neural plate (anp) within the pre-placodal field. The ADH primordium is fully segregated from the anterior neural border cells and the neighboring olfactory placodes both in terms of precursor cells and molecular profile from head fold stages onwards. The placode becomes visible as a molecularly characteristic ectodermal thickening from stage HH10 onwards. The onset of ADH genoarchitectonic regionalization into intermediate and anterior lobes occurs at closed neural tube stages.

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Section: Resultsmentioning

confidence: 88%

Origin and early development of the chicken adenohypophysis

et al. 2015

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Identification of marker genes for pars tuberalis morphogenesis in chick embryo: expression of Cytokine-like 1 and Gap junction protein alpha 5 in pars tuberalis

et al. 2016

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The adenohypophysis is formed from the oral ectoderm and consists of the pars distalis (PD), pars intermedia, and pars tuberalis (PT). The mechanisms of PD development have been extensively studied, and the cellular differentiation of the PD is well understood. However, the morphogenesis and differentiation of the PT are still unclear, and the genes expressed during PT development remain largely unknown. We have explored genes specifically expressed in the PT during embryonic development and analyzed their spatiotemporal expression patterns. Microarray analysis of laser-captured PT and PD tissues obtained from chick embryos on embryonic day 10 (E10.0) has shown high expression of Cytokine-like 1 (CYTL1) and Gap junction protein alpha 5 (GJA5) genes in the PT. Detailed analysis of these spatiotemporal expression patterns during chick embryo development by in situ hybridization has revealed that CYTL1 mRNA first appears in the lateral head ectoderm and ventral head ectoderm at E1.5. The expression of CYTL1 moves into Rathke's pouch at E2.5 and is then localized in the PT primordium where it is continuously expressed until E12.0. GJA5 mRNA is transiently detected in the PT primordium from E6.0 to E12.0, whereas its expression is not detected in the PD during development. Thus, these genes might be involved in the regulation mechanisms of PT development and could be useful markers for PT development.

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Changes in Gene Expression during Pituitary Morphogenesis and Organogenesis in the Chick Embryo

2011

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The anterior pituitary gland plays an important role in the regulation of many physiological processes. Formation of Rathke's pouch (RP), the precursor of the anterior pituitary, involves evagination of the oral ectoderm in a multi-step process regulated by cell interactions, signaling pathways, and transcription factors. Chickens are an excellent model to study development because of the availability of large sample sizes, accurate timing of development, and embryo accessibility. The aim of this study was to quantify mRNA expression patterns in the developing chicken anterior pituitary to evaluate the chicken embryo as a model for mammalian pituitary development. The expression profiles of 16 genes differentially expressed in RP and neuroectoderm were determined in this study. Among these, Pitx1, Pitx2, and Hesx1 mRNA levels were high on embryonic days (e) 2.5 to e3 in RP and decreased during development. Expression of Pit1 and Tbx19 mRNA in RP reached the highest levels by e7 and e6.5, respectively. Levels of glycoprotein subunit α mRNA increased beginning at e4. FGF8 mRNA showed the highest expression at e3 to e3.5 in neuroectoderm. BMP2 showed slight decreases in mRNA expression in both tissues during development, while Isl1 and Noggin mRNA expression increased in later development. Taken together, we present the first quantitative transcriptional profile of pituitary organogenesis. Our results will help further understanding of the functional development of this gland. Moreover, because of the high similarity in gene expression patterns observed between chicken and mouse, chickens could serve as an excellent model to study genetic and molecular mechanisms underlying pituitary development.

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Origin of Adenohypophysial Lobes and Cells from Rathke’s Pouch in Chicken (Gallus gallus) and Japanese Quail (Coturniz coturniz japonica). Expression of Calcium‐Binding Proteins

Cited by 3 publications

References 42 publications

Origin and early development of the chicken adenohypophysis

Origin and early development of the chicken adenohypophysis

Identification of marker genes for pars tuberalis morphogenesis in chick embryo: expression of Cytokine-like 1 and Gap junction protein alpha 5 in pars tuberalis

Changes in Gene Expression during Pituitary Morphogenesis and Organogenesis in the Chick Embryo

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