Origin maturation and recruitment of mast cell precursors

Abstract

Introduction 3. Origin of mast cell committed precursors 3.1. Mouse bone marrow derived mast cell committed precursor 3.2. Human bone marrow derived mast cell committed precursor 4. Mast cell maturation 4.1. Maturation of bone marrow derived mast cells 4.2. Maturation of mast cells at peripheral sites 4.3. Major factors affecting mast cell proliferation and maturation 5. Mast cell recruitment 6. Conclusions 7. References

The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis

“…Mast cell distribution relies on mechanisms of constitutive homing, enhanced recruitment, survival, and local maturation of mast cell progenitors. In physiological conditions, their numbers remain relatively constant; however, proliferation and the enhancement of the mechanisms described above lead to mast cell hyperplasia during hypersensitivity reactions and infections and in response to various disease processes [27–29]. …”

Mechanisms underlying the localisation of mast cells in tissues

“…Mast cells, however, mature in peripheral tissues and committed progenitors are detected only in low numbers in the bone marrow and blood [15][16][17]. Once recruited to the tissues, mast cells mature under the influence of cytokines and growth factors in the local microenvironment [18,19]. The low number of mast cell progenitors in the bone marrow, blood and tissues makes it challenging to address their migratory mechanisms.…”

IL-33 and Thymic Stromal Lymphopoietin in mast cell functions

“…Several growth factors and cytokines have been demonstrated to be critical for mast cell growth, development and differentiation, including SCF, IL-6 and IL-9 (Hu et al, 2007;Jamur and Oliver, 2011;Saito et al, 1996). TSLP plays an important role in the maturation of MCs (Han et al, 2014).…”