Origin, evolution, and diversification of inositol 1,4,5-trisphosphate 3-kinases in plants and animals
Tao Xiong,
Zaibao Zhang,
Tianyu Fan
et al.
Abstract:Background
In Eukaryotes, inositol polyphosphates (InsPs) represent a large family of secondary messengers and play crucial roes in various cellular processes. InsPs are synthesized through a series of pohophorylation reactions catalyzed by various InsP kinases in a sequential manner. Inositol 1,4,5-trisphosphate 3-kinase (IP3 3-kinase/IP3K), one member of InsP kinase, plays important regulation roles in InsPs metabolism by specifically phosphorylating inositol 1,4,5-trisphosphate (IP3) to inos… Show more
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