Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review

Peivasteh-Roudsari, Leila; Barzegar-Bafrouei, Raziyeh; Sharifi, Kurush Aghbolagh; Azimi-salim, Shamimeh; Karami, Marzieh; Abedinzadeh, Solmaz; Asadinezhad, Shabnam; Tajdar-Oranj, Behrouz; Mahdavi, Vahideh; Alizadeh, Adel Mirza; Sadighara, Parisa; Ferrante, Margherita; Conti, Gea Oliveri; Aliyeva, Aynura; Khaneghah, Amin Mousavi

doi:10.1016/j.heliyon.2023.e18140

Cited by 24 publications

(9 citation statements)

References 337 publications

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“…Bisphenols are commonly used in the production of certain food packaging materials. When food or beverages contact with these packages, there is a possibility of bisphenol leaching into the food or drink, especially under certain conditions such as high temperatures or acidic environments [ 37 ]. Our results indicate that, in addition to BPA-free products, consideration of BPF-free and BPS-free plastic containers may also be necessary.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Bisphenol A and Its Analogs among Thai School-Age Children

Numsriskulrat,

Teeranathada,

Bongsebandhu-Phubhakdi

et al. 2023

Toxics

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Bisphenol F (BPF) and bisphenol S (BPS) have become popular substitutes for bisphenol A (BPA) in the plastic industry due to concerns over BPA’s adverse effects. However, there is limited information on children’s exposure to these chemicals. This study aims to assess the extent of BPA, BPF, and BPS exposure and determine factors that influence such exposure. A group of Thai children (age 6–13 years, N = 358) were recruited between October 2019 and 2020. Two first-morning voids were collected one week apart. Demographic and exposure-related information was gathered. Urinary concentrations of bisphenols were analyzed by liquid chromatography and tandem mass spectrometry. Correlation between bisphenol concentrations with age, body weight, and sources of bisphenol exposure, was determined using generalized estimating equations with linear model. BPA, BPF, and BPS were detected at 79.6%, 31.0%, and 16.8%, with geometric mean (GM) concentrations of 1.41, 0.013, and 0.014 ng/mL, respectively. Younger children aged <10 years exhibited 1.3–1.6 times higher GM levels of all bisphenols compared to older children. Exposure to food stored in plastic containers was associated with higher levels of BPF and BPS. In conclusion, BPA was the most frequently detected bisphenol in urine samples from Thai children, followed by BPF and BPS.

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Section: Discussionmentioning

confidence: 99%

Exposure to Bisphenol A and Its Analogs among Thai School-Age Children

Numsriskulrat,

Teeranathada,

Bongsebandhu-Phubhakdi

et al. 2023

Toxics

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“…EDCs are man-made chemicals ubiquitously found in the atmosphere as aerosols and particulate matter [ 145 ], water [ 146 ], pesticides [ 147 ], metals such as cadmium (Cd), mercury (Hg), arsenic (As), lead (Pb), manganese (Mn), and zinc (Zn) [ 148 ], additives or contaminated food such as dairy products, fish, meat, eggs, and vegetables, bottled water and canned food [ 149 ], and cosmetics and personal care products [ 150 ]. EDCs arrive in the human body through ingestion, inhalation, and/or the transdermal route, bioaccumulate, and interfere with endocrine, immune, and other systems, leading to a disruption of the endocrine signaling and metabolic pathways, and inducing life-long effects and negative consequences even for the next generation [ 151 ].…”

Section: Exposure To Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

Breast Cancer Exposomics

Neagu,

Jayaweera,

Corrice

et al. 2024

Life

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We are exposed to a mixture of environmental man-made and natural xenobiotics. We experience a wide spectrum of environmental exposure in our lifetime, including the effects of xenobiotics on gametogenesis and gametes that undergo fertilization as the starting point of individual development and, moreover, in utero exposure, which can itself cause the first somatic or germline mutation necessary for breast cancer (BC) initiation. Most xenobiotics are metabolized or/and bioaccumulate and biomagnify in our tissues and cells, including breast tissues, so the xenobiotic metabolism plays an important role in BC initiation and progression. Many considerations necessitate a more valuable explanation regarding the molecular mechanisms of action of xenobiotics which act as genotoxic and epigenetic carcinogens. Thus, exposomics and the exposome concept are based on the diversity and range of exposures to physical factors, synthetic chemicals, dietary components, and psychosocial stressors, as well as their associated biologic processes and molecular pathways. Existing evidence for BC risk (BCR) suggests that food-borne chemical carcinogens, air pollution, ionizing radiation, and socioeconomic status are closely related to breast carcinogenesis. The aim of this review was to depict the dynamics and kinetics of several xenobiotics involved in BC development, emphasizing the role of new omics fields related to BC exposomics, such as environmental toxicogenomics, epigenomics and interactomics, metagenomics, nutrigenomics, nutriproteomics, and nutrimiRomics. We are mainly focused on food and nutrition, as well as endocrine-disrupting chemicals (EDCs), involved in BC development. Overall, cell and tissue accumulation and xenobiotic metabolism or biotransformation can lead to modifications in breast tissue composition and breast cell morphology, DNA damage and genomic instability, epimutations, RNA-mediated and extracellular vesicle effects, aberrant blood methylation, stimulation of epithelial–mesenchymal transition (EMT), disruption of cell–cell junctions, reorganization of the actin cytoskeleton, metabolic reprogramming, and overexpression of mesenchymal genes. Moreover, the metabolism of xenobiotics into BC cells impacts almost all known carcinogenic pathways. Conversely, in our food, there are many bioactive compounds with anti-cancer potential, exerting pro-apoptotic roles, inhibiting cell cycle progression and proliferation, migration, invasion, DNA damage, and cell stress conditions. We can conclude that exposomics has a high potential to demonstrate how environmental exposure to xenobiotics acts as a double-edged sword, promoting or suppressing tumorigenesis in BC.

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“…Endocrine-disrupting chemicals (EDCs) are a growing public health concern worldwide. PAEs, lead, cadmium, organochlorine pesticides, etc., are all EDCs [9]. Recently, residues of EDCs in vegetables are receiving intensive attention from the public.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and Risk Assessment of Pesticides, Phthalates, and Heavy Metal Residues in Vegetables from Hydroponic and Conventional Cultivation

Chen,

Yao,

Zhou

et al. 2024

Foods

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Hydroponic cultivation of fresh produce is gaining popularity worldwide, but few studies have provided a comparative assessment of hydroponic and conventional soil-based vegetables. In this study, we analyzed a series of hazardous chemicals, including 120 pesticides, 18 phthalates (PAEs), and 2 heavy metals (lead and cadmium) in four vegetable commodities (lettuces, celeries, tomatoes, and cucumbers) from hydroponic and conventional soil-based cultivation. Our study showed that at least one pesticide was present in 84% of the conventionally grown samples, whereas only 30% of the hydroponic samples contained detectable pesticide residues. Regarding the total PAE concentrations, there was no significant difference between conventional and hydroponic vegetables. The lead and cadmium residues in conventionally cultivated vegetables were significantly higher than in those produced from hydroponic cultivation. Lead is the primary heavy metal pollutant across all vegetable samples. The hazard index (HI) values of the hydroponic and conventional vegetables were 0.22 and 0.64, respectively. Since both values are below one, the exposure to these hazardous chemicals through consumption of the studied vegetables may not pose a significant health risk. The HI values also suggested that the health risks of eating hydroponic vegetables are lower than for conventional soil-based vegetables.

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Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review

Cited by 24 publications

References 337 publications

Exposure to Bisphenol A and Its Analogs among Thai School-Age Children

Exposure to Bisphenol A and Its Analogs among Thai School-Age Children

Breast Cancer Exposomics

Occurrence and Risk Assessment of Pesticides, Phthalates, and Heavy Metal Residues in Vegetables from Hydroponic and Conventional Cultivation

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