Origin and reduction of motion and f0 artifacts in high resolution T2*-weighted magnetic resonance imaging: Application in Alzheimer's disease patients

Versluis, Mieke; Peeters, Johannes M.; Rooden, Sanneke van; Grond, Jeroen van der; Buchem, Mark A. van; Webb, Andrew; Osch, Matthias J.P. van

doi:10.1016/j.neuroimage.2010.03.048

Cited by 77 publications

(145 citation statements)

References 27 publications

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“…Neurodegenerative diseases in particular are associated with elevated iron depositions to which T 2 * weighted imaging is extremely sensitive (Bartzokis et al, 1999;Mainero et al, 2009;Stankiewicz et al, 2007;van Rooden et al, 2009). Unfortunately, patients with neurodegenerative diseases often have difficulties lying still for more than a few minutes, while T 2 * weighted imaging is prone to motion artifacts (Versluis et al, 2010). The proposed protocol is fast and will, hence, allow increased coverage in acceptable scanning time, or fast scanning of a limited brain area with lower chance of motion artifacts.…”

Section: Discussionmentioning

confidence: 99%

“…This hampers the practical use of T 2 * weighted imaging for fundamental research of normal physiology or disease. Long imaging times are also problematic because they increase the possibility of subject motion during the scan duration resulting in blurring or unusable images (Versluis et al, 2010). The long imaging times are due to the relatively low signal-tonoise ratio (SNR) efficiency of the spoiled GRE sequence.…”

Section: Introductionmentioning

confidence: 99%

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Fast high resolution whole brain T2* weighted imaging using echo planar imaging at 7T

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fast high resolution whole brain T2* weighted imaging using echo planar imaging at 7T

et al. 2011

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“…Although we corrected for resonance frequency variations, which are the main contributor to decreased image quality in AD patients, with a navigator echo [34], it is highly likely that even subvoxel degrees of motion blur the hypointense foci.…”

Section: Discussionmentioning

confidence: 99%

“…These sequences are very sensitive to image artifacts arising from resonance frequency fluctuations within the brain caused by slight patient movements, even in areas significantly away from the head. A navigator echo was included to correct for these artifacts [34]. Shimming up to third order was performed using an imagebased shimming approach [35].…”

Section: Image Acquisitionmentioning

confidence: 99%

Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker

Rooden

Versluis

Liem

et al. 2013

Alzheimer's & Dementia

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Background: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD). Methods: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.Results: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P , .005), and this was associated with individual Mini-Mental State Examination scores (r 5 20.54, P , .05). Conclusion: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.

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“…The frequency difference between inhale and exhale is 2–8 Hz at 7T 24, 25. Assuming TE = 30 ms for a functional MRI (fMRI) EPI scan, 8 Hz would lead to a phase change of 86°.…”

Section: Methodsmentioning

confidence: 99%

Two‐dimensional‐NGC‐SENSE‐GRAPPA for fast, ghosting‐robust reconstruction of in‐plane and slice‐accelerated blipped‐CAIPI echo planar imaging

Koopmans

2016

Magnetic Resonance in Med

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PurposeGhosting‐robust reconstruction of blipped‐CAIPI echo planar imaging simultaneous multislice data with low computational load.MethodsTo date, Slice‐GRAPPA, with “odd–even” kernels that improve ghosting performance, has been the framework of choice for such reconstructions due to its predecessor SENSE‐GRAPPA being deemed unsuitable for blipped‐CAIPI data. Modifications to SENSE‐GRAPPA are used to restore CAIPI compatibility and to make it robust against ghosting. Two implementations are tested, one where slices and in‐plane unaliasing are dealt in the same serial manner as in Slice‐GRAPPA [referred to as one‐dimensional (1D)‐NGC‐SENSE‐GRAPPA, where NGC stands for Nyquist Ghost Corrected] and one where both are unaliased in a single step (2D‐NGC‐SENSE‐GRAPPA), which is analytically and experimentally shown to be computationally cheaper.ResultsThe 1D‐NGC‐SENSE‐GRAPPA and odd‐even Slice‐GRAPPA perform identically, whereas 2D‐NGC‐SENSE‐GRAPPA shows reduced error propagation, less residual ghosting when reliable reference data were available. When the latter was not the case, error propagation was increased.ConclusionUnlike Slice‐GRAPPA, SENSE‐GRAPPA operates fully within the GRAPPA framework, for which improved reconstructions (e.g., iterative, nonlinear) have been developed over the past decade. It could, therefore, bring benefit to the reconstruction of SMS data as an attractive alternative to Slice‐GRAPPA. Magn Reson Med 77:998–1009, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Origin and reduction of motion and f0 artifacts in high resolution T2*-weighted magnetic resonance imaging: Application in Alzheimer's disease patients

Cited by 77 publications

References 27 publications

Fast high resolution whole brain T2* weighted imaging using echo planar imaging at 7T

Fast high resolution whole brain T2* weighted imaging using echo planar imaging at 7T

Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker

Two‐dimensional‐NGC‐SENSE‐GRAPPA for fast, ghosting‐robust reconstruction of in‐plane and slice‐accelerated blipped‐CAIPI echo planar imaging

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