Origin and functional specializations of DC subsets in the lung

Plantinga, Maud; Hammad, Hamida; Lambrecht, Bart N.

doi:10.1002/eji.201040562

Cited by 64 publications

(53 citation statements)

References 66 publications

(104 reference statements)

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“…Similarly, the involvement of intraepithelial conventional CD11b -DCs (cDCs), lamina propia CD11B high cDCs and plasmacytoid (pDCs) without danger signals add to this anti-inflammatory state of the immune system [16]. As the Concentrations of the polymorphonuclear leucocytes (PMN) mobilizer granulocyte colony-stimulating factor (G-CSF) were determined by enzyme-linked immunosorbent assay (ELISA).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, professional immune cells, especially alveolar macrophages and supported by type II epithelial cells, are located in the alveoli and with their PRRs they can rapidly recognize the PAMPs of pathogens being inhaled or aspirated to the periphery of the lungs [3,4,16,17]. The initiated inflammation follows within few hours, primarily with recruitment of PMNs, and influx of humoral factors such as complement, defensins and cytokines, as the alveolar lumen and vascular lumen is within a distance of a few mm.…”

Section: Discussionmentioning

confidence: 99%

“…The initiated inflammation follows within few hours, primarily with recruitment of PMNs, and influx of humoral factors such as complement, defensins and cytokines, as the alveolar lumen and vascular lumen is within a distance of a few mm. In chronic infection, IgG synthesized in the medulla of the regional lymph nodes and the bone marrow, and induced by different subsets of CD11B high and CD11B -cDCs and pDCs induced by danger signals via the alveolar macrophages and type II alveolar epithelial cells, will also be present in the airway lumen resulting in opsonin activation of PMNs and complement activation, thereby further enhancing inflammation [6,7,15,16,17].…”

Section: Discussionmentioning

confidence: 99%

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Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection

Christophersen

Trøstrup

Damlund

et al. 2012

Clinical and Experimental Immunology

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SummaryChronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients is characterized by biofilms, tolerant to antibiotics and host responses. Instead, immune responses contribute to the tissue damage. However, this may depend on localization of infection in the upper conductive or in the peripheral respiratory zone. To study this we produced two distinct sizes of small alginate beads (SB) and large beads (LB) containing P. aeruginosa. In total, 175 BALB/c mice were infected with either SB or LB. At day 1 the quantitative bacteriology was higher in the SB group compared to the LB group (P < 0·003). For all time-points smaller biofilms were identified by Alcian blue staining in the SB group (P < 0·003). Similarly, the area of the airways in which biofilms were identified were smaller (P < 0·0001). A shift from exclusively endobronchial to both parenchymal and endobronchial localization of inflammation from day 1 to days 2/3 (P < 0·05), as well as a faster resolution of inflammation at days 5/6, was observed in the SB group (P < 0·03). Finally, both the polymorphonuclear neutrophil leucocyte (PMN) mobilizer granulocyte colony-stimulating factor (G-CSF) and chemoattractant macrophage inflammatory protein-2 (MIP-2) were increased at day 1 in the SB group (P < 0·0001). In conclusion, we have established a model enabling studies of host responses in different pulmonary zones. An effective recognition of and a more pronounced host response to infection in the peripheral zones, indicating that increased lung damage was demonstrated. Therefore, treatment of the chronic P. aeruginosa lung infection should be directed primarily at the peripheral lung zone by combined intravenous and inhalation antibiotic treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection

Christophersen

Trøstrup

Damlund

et al. 2012

Clinical and Experimental Immunology

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“…As Plantinga et al [67] summarize, pDC, and not just classical DC, contribute to this vital tolerizing function.…”

Section: And the Induction Of Th2 Responses To Allergens And Parasmentioning

confidence: 99%

“…Plantinga, Hammad and Lambrecht [67] delve deeply into pulmonary DC to study DC biology at a pivotal mucosal surface. They emphasize that different DC subsets exert different functions, from the induction of Treg specific for environmental antigens to the formation of both protective IgA and allergenic IgE responses.…”

Section: And the Induction Of Th2 Responses To Allergens And Parasmentioning

confidence: 99%

Some active areas of DC research and their medical potential

Steinman

2010

Eur J Immunol

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This Viewpoint series provides authoritative and detailed outlines of exciting areas of DC research. Some of the subjects that frequently come up include development of DC; distribution of DC in lymphoid and non‐lymphoid tissues such as skin, intestine and lung; different forms or subsets of DC; and the role of DC in initiating tolerance and immunity. In this Preface, I will introduce the Viewpoints and consider some future challenges as well as the medical relevance of DC research.

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Langerin, the “Catcher in the Rye”: An important receptor for pathogens on Langerhans cells

Stoitzner

Romani

2011

Eur J Immunol

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Langerhans cells (LCs) are a distinct subset of DCs that resides in the epidermis and other epithelia. They are potent antigen-presenting cells and strong inducers of T-cell responses. Like other DC types, LCs express C-type lectins that serve as antigen/pathogen uptake receptors, with Langerin/CD207 being the characteristic LC C-type lectin. however, presentation of this virus to CD4 1 T cells occurs and is dependent on virus capture by Langerin. Thus, cross-presentation of measles virus may be left to skin DCs other than LCs. This highlights the complexity of anti-viral T-cell responses that originate in the skin and also emphasizes the need for intensified investigations into human skin DCs in order to be able to ultimately harness their potential for immunotherapy.

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Origin and functional specializations of DC subsets in the lung

Cited by 64 publications

References 66 publications

Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection

Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection

Some active areas of DC research and their medical potential

Langerin, the “Catcher in the Rye”: An important receptor for pathogens on Langerhans cells

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